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Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds.
Nutr J 2014; 13:101NJ

Abstract

BACKGROUND

Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption.

OBJECTIVE

The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins.

METHODS

Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months.

RESULTS

No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12: p = 0.045; week 24: p = 0.039) and routine (week 12: p = 0.031; week 24: p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p < 0.001) with total and LDL-C levels.

CONCLUSION

Results demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction.

TRIAL REGISTRATION

clinicaltrials.gov Identifier: NCT00438425.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableRichardson Centre for Functional Foods and Nutraceuticals, Winnipeg, MB R3T 2 N2, Canada. peter_jones@umanitoba.ca.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25326876

Citation

Ramprasath, Vanu R., et al. "Consumption of a Dietary Portfolio of Cholesterol Lowering Foods Improves Blood Lipids Without Affecting Concentrations of Fat Soluble Compounds." Nutrition Journal, vol. 13, 2014, p. 101.
Ramprasath VR, Jenkins DJ, Lamarche B, et al. Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds. Nutr J. 2014;13:101.
Ramprasath, V. R., Jenkins, D. J., Lamarche, B., Kendall, C. W., Faulkner, D., Cermakova, L., ... Jones, P. J. (2014). Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds. Nutrition Journal, 13, p. 101. doi:10.1186/1475-2891-13-101.
Ramprasath VR, et al. Consumption of a Dietary Portfolio of Cholesterol Lowering Foods Improves Blood Lipids Without Affecting Concentrations of Fat Soluble Compounds. Nutr J. 2014 Oct 18;13:101. PubMed PMID: 25326876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds. AU - Ramprasath,Vanu R, AU - Jenkins,David J A, AU - Lamarche,Benoit, AU - Kendall,Cyril W C, AU - Faulkner,Dorothea, AU - Cermakova,Luba, AU - Couture,Patrick, AU - Ireland,Chris, AU - Abdulnour,Shahad, AU - Patel,Darshna, AU - Bashyam,Balachandran, AU - Srichaikul,Korbua, AU - de Souza,Russell J, AU - Vidgen,Edward, AU - Josse,Robert G, AU - Leiter,Lawrence A, AU - Connelly,Philip W, AU - Frohlich,Jiri, AU - Jones,Peter J H, Y1 - 2014/10/18/ PY - 2014/06/10/received PY - 2014/10/07/accepted PY - 2014/10/20/entrez PY - 2014/10/20/pubmed PY - 2015/3/31/medline SP - 101 EP - 101 JF - Nutrition journal JO - Nutr J VL - 13 N2 - BACKGROUND: Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption. OBJECTIVE: The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins. METHODS: Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months. RESULTS: No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12: p = 0.045; week 24: p = 0.039) and routine (week 12: p = 0.031; week 24: p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p < 0.001) with total and LDL-C levels. CONCLUSION: Results demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00438425. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/25326876/Consumption_of_a_dietary_portfolio_of_cholesterol_lowering_foods_improves_blood_lipids_without_affecting_concentrations_of_fat_soluble_compounds_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-101 DB - PRIME DP - Unbound Medicine ER -