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Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds.

Abstract

BACKGROUND

Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption.

OBJECTIVE

The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins.

METHODS

Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months.

RESULTS

No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12: p = 0.045; week 24: p = 0.039) and routine (week 12: p = 0.031; week 24: p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p < 0.001) with total and LDL-C levels.

CONCLUSION

Results demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction.

TRIAL REGISTRATION

clinicaltrials.gov Identifier: NCT00438425.

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  • Authors+Show Affiliations

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    Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, MB R3T 2 N2, Canada. peter_jones@umanitoba.ca.

    Source

    Nutrition journal 13: 2014 Oct 18 pg 101

    MeSH

    Adult
    Canada
    Carotenoids
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Diet
    Dietary Fiber
    Feeding Behavior
    Female
    Follow-Up Studies
    Humans
    Hyperlipidemias
    Lutein
    Lycopene
    Male
    Middle Aged
    Nuts
    Phytosterols
    Single-Blind Method
    Sitosterols
    Tocopherols
    Triglycerides
    Vitamin A
    Vitamins
    beta Carotene

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25326876

    Citation

    Ramprasath, Vanu R., et al. "Consumption of a Dietary Portfolio of Cholesterol Lowering Foods Improves Blood Lipids Without Affecting Concentrations of Fat Soluble Compounds." Nutrition Journal, vol. 13, 2014, p. 101.
    Ramprasath VR, Jenkins DJ, Lamarche B, et al. Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds. Nutr J. 2014;13:101.
    Ramprasath, V. R., Jenkins, D. J., Lamarche, B., Kendall, C. W., Faulkner, D., Cermakova, L., ... Jones, P. J. (2014). Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds. Nutrition Journal, 13, p. 101. doi:10.1186/1475-2891-13-101.
    Ramprasath VR, et al. Consumption of a Dietary Portfolio of Cholesterol Lowering Foods Improves Blood Lipids Without Affecting Concentrations of Fat Soluble Compounds. Nutr J. 2014 Oct 18;13:101. PubMed PMID: 25326876.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds. AU - Ramprasath,Vanu R, AU - Jenkins,David J A, AU - Lamarche,Benoit, AU - Kendall,Cyril W C, AU - Faulkner,Dorothea, AU - Cermakova,Luba, AU - Couture,Patrick, AU - Ireland,Chris, AU - Abdulnour,Shahad, AU - Patel,Darshna, AU - Bashyam,Balachandran, AU - Srichaikul,Korbua, AU - de Souza,Russell J, AU - Vidgen,Edward, AU - Josse,Robert G, AU - Leiter,Lawrence A, AU - Connelly,Philip W, AU - Frohlich,Jiri, AU - Jones,Peter J H, Y1 - 2014/10/18/ PY - 2014/06/10/received PY - 2014/10/07/accepted PY - 2014/10/20/entrez PY - 2014/10/20/pubmed PY - 2015/3/31/medline SP - 101 EP - 101 JF - Nutrition journal JO - Nutr J VL - 13 N2 - BACKGROUND: Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption. OBJECTIVE: The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins. METHODS: Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months. RESULTS: No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12: p = 0.045; week 24: p = 0.039) and routine (week 12: p = 0.031; week 24: p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p < 0.001) with total and LDL-C levels. CONCLUSION: Results demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00438425. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/25326876/Consumption_of_a_dietary_portfolio_of_cholesterol_lowering_foods_improves_blood_lipids_without_affecting_concentrations_of_fat_soluble_compounds_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-101 DB - PRIME DP - Unbound Medicine ER -