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Triple trouble--macrophage activation syndrome in a case of severe leptospirosis and scrub typhus co-infection.
J Assoc Physicians India. 2014 Jan; 62(1):58-61.JA

Abstract

Macrophage activation syndrome is a potentially life threatening phenomenon characterised by aggressive proliferation of macrophages and T lymphocytes leading to haemophagocytosis of other blood cells and multi organ failure. Here we present a very unusual combination of leptospirosis and scrub typhus infection leading to macrophage activation syndrome. Scrub typhus associated with macrophage activation syndrome has rarely been reported in India. A 40 year old female presented with high grade fever, seizures, bodyache, arthralgia and severe breathlessness. Investigations revealed persistent thrombocytopenia, impaired liver function tests, renal dysfunction, leptospiral IgM ELISA positive and a positive Weil Felix test. There was evidence of haemophagocytosis in bone marrow. Macrophage activation syndrome if left untreated has been associated with rapidly fatal outcome and early treatment can help us save that one precious thing..called life..!

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25327097

Citation

Diwan, A G., et al. "Triple Trouble--macrophage Activation Syndrome in a Case of Severe Leptospirosis and Scrub Typhus Co-infection." The Journal of the Association of Physicians of India, vol. 62, no. 1, 2014, pp. 58-61.
Diwan AG, Shewale R, Iyer S, et al. Triple trouble--macrophage activation syndrome in a case of severe leptospirosis and scrub typhus co-infection. J Assoc Physicians India. 2014;62(1):58-61.
Diwan, A. G., Shewale, R., Iyer, S., Nisal, A., & Agrawa, P. (2014). Triple trouble--macrophage activation syndrome in a case of severe leptospirosis and scrub typhus co-infection. The Journal of the Association of Physicians of India, 62(1), 58-61.
Diwan AG, et al. Triple Trouble--macrophage Activation Syndrome in a Case of Severe Leptospirosis and Scrub Typhus Co-infection. J Assoc Physicians India. 2014;62(1):58-61. PubMed PMID: 25327097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triple trouble--macrophage activation syndrome in a case of severe leptospirosis and scrub typhus co-infection. AU - Diwan,A G, AU - Shewale,Rahul, AU - Iyer,Shivakumar, AU - Nisal,Amit, AU - Agrawa,Prakhar, PY - 2014/10/21/entrez PY - 2014/10/21/pubmed PY - 2014/11/7/medline SP - 58 EP - 61 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 62 IS - 1 N2 - Macrophage activation syndrome is a potentially life threatening phenomenon characterised by aggressive proliferation of macrophages and T lymphocytes leading to haemophagocytosis of other blood cells and multi organ failure. Here we present a very unusual combination of leptospirosis and scrub typhus infection leading to macrophage activation syndrome. Scrub typhus associated with macrophage activation syndrome has rarely been reported in India. A 40 year old female presented with high grade fever, seizures, bodyache, arthralgia and severe breathlessness. Investigations revealed persistent thrombocytopenia, impaired liver function tests, renal dysfunction, leptospiral IgM ELISA positive and a positive Weil Felix test. There was evidence of haemophagocytosis in bone marrow. Macrophage activation syndrome if left untreated has been associated with rapidly fatal outcome and early treatment can help us save that one precious thing..called life..! SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/25327097/Triple_trouble__macrophage_activation_syndrome_in_a_case_of_severe_leptospirosis_and_scrub_typhus_co_infection_ L2 - http://www.diseaseinfosearch.org/result/4178 DB - PRIME DP - Unbound Medicine ER -