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IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome.
Allergy. 2015 Jan; 70(1):59-66.A

Abstract

BACKGROUND

Birch pollen-associated plant food allergy is caused by Bet v 1-specific IgE, but presence of cross-reactive IgE to related allergens does not predict food allergy. The role of other immunoglobulin isotypes in the birch pollen-plant food syndrome has not been investigated in detail.

METHODS

Bet v 1-sensitized birch pollen-allergic patients (n = 35) were diagnosed for food allergy by standardized interviews, skin prick tests, prick-to-prick tests and ImmunoCAP. Concentrations of allergen-specific IgE, IgG1, IgG4 and IgA to seven Bet v 1-related food allergens were determined by ELISA.

RESULTS

Bet v 1, Cor a 1, Mal d 1 and Pru p 1 bound IgE from all and IgG4 and IgA from the majority of sera. Immunoglobulins to Gly m 4, Vig r 1 and Api g 1.01 were detected in <65% of the sera. No significant correlation was observed between plant food allergy and increased or reduced levels of IgE, IgG1, IgG4 or IgA specific to most Bet v 1-related allergens. Api g 1-specific IgE was significantly (P = 0.01) elevated in celeriac-allergic compared with celeriac-tolerant patients. Likewise, frequencies of IgE (71% vs 15%; P = 0.01) and IgA (86% vs 38%; P = 0.04) binding to Api g 1.01 were increased.

CONCLUSION

Measurements of allergen-specific immunoglobulins are not suitable for diagnosing Bet v 1-mediated plant food allergy to hazelnut and Rosaceae fruits. In contrast, IgE and IgA to the distantly related allergen Api g 1 correlate with allergy to celeriac.

Authors+Show Affiliations

Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25327982

Citation

Guhsl, E E., et al. "IgE, IgG4 and IgA Specific to Bet V 1-related Food Allergens Do Not Predict Oral Allergy Syndrome." Allergy, vol. 70, no. 1, 2015, pp. 59-66.
Guhsl EE, Hofstetter G, Lengger N, et al. IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome. Allergy. 2015;70(1):59-66.
Guhsl, E. E., Hofstetter, G., Lengger, N., Hemmer, W., Ebner, C., Fröschl, R., Bublin, M., Lupinek, C., Breiteneder, H., & Radauer, C. (2015). IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome. Allergy, 70(1), 59-66. https://doi.org/10.1111/all.12534
Guhsl EE, et al. IgE, IgG4 and IgA Specific to Bet V 1-related Food Allergens Do Not Predict Oral Allergy Syndrome. Allergy. 2015;70(1):59-66. PubMed PMID: 25327982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome. AU - Guhsl,E E, AU - Hofstetter,G, AU - Lengger,N, AU - Hemmer,W, AU - Ebner,C, AU - Fröschl,R, AU - Bublin,M, AU - Lupinek,C, AU - Breiteneder,H, AU - Radauer,C, Y1 - 2014/11/30/ PY - 2014/10/15/accepted PY - 2014/10/21/entrez PY - 2014/10/21/pubmed PY - 2015/8/6/medline KW - Bet v 1 KW - IgA KW - IgE KW - IgG KW - food allergy SP - 59 EP - 66 JF - Allergy JO - Allergy VL - 70 IS - 1 N2 - BACKGROUND: Birch pollen-associated plant food allergy is caused by Bet v 1-specific IgE, but presence of cross-reactive IgE to related allergens does not predict food allergy. The role of other immunoglobulin isotypes in the birch pollen-plant food syndrome has not been investigated in detail. METHODS: Bet v 1-sensitized birch pollen-allergic patients (n = 35) were diagnosed for food allergy by standardized interviews, skin prick tests, prick-to-prick tests and ImmunoCAP. Concentrations of allergen-specific IgE, IgG1, IgG4 and IgA to seven Bet v 1-related food allergens were determined by ELISA. RESULTS: Bet v 1, Cor a 1, Mal d 1 and Pru p 1 bound IgE from all and IgG4 and IgA from the majority of sera. Immunoglobulins to Gly m 4, Vig r 1 and Api g 1.01 were detected in <65% of the sera. No significant correlation was observed between plant food allergy and increased or reduced levels of IgE, IgG1, IgG4 or IgA specific to most Bet v 1-related allergens. Api g 1-specific IgE was significantly (P = 0.01) elevated in celeriac-allergic compared with celeriac-tolerant patients. Likewise, frequencies of IgE (71% vs 15%; P = 0.01) and IgA (86% vs 38%; P = 0.04) binding to Api g 1.01 were increased. CONCLUSION: Measurements of allergen-specific immunoglobulins are not suitable for diagnosing Bet v 1-mediated plant food allergy to hazelnut and Rosaceae fruits. In contrast, IgE and IgA to the distantly related allergen Api g 1 correlate with allergy to celeriac. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/25327982/IgE_IgG4_and_IgA_specific_to_Bet_v_1_related_food_allergens_do_not_predict_oral_allergy_syndrome_ L2 - https://doi.org/10.1111/all.12534 DB - PRIME DP - Unbound Medicine ER -