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Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria.
Pan Afr Med J. 2014; 17:301.PA

Abstract

INTRODUCTION

Transmission of human T-lymphotropic viruses (HTLV) occurs from mother to child, by sexual contact and blood transfusion. Presently, in most centres in Nigeria, there is no routine pre-transfusion screening for HTLV. The study aims to determine the prevalence of HTLV-1 and HTLV-2 among healthy blood donors at a tertiary centre in Lagos.

METHODS

A cross-sectional study was carried out at the blood donor clinic of the Lagos State University Teaching Hospital (LASUTH), Ikeja. About 5 mls of venous blood was collected from each subject into a sterile plain bottle after obtaining subject's consent. The serum separated and stored at -200C. Sera were assayed for HTLV by an enzyme-linked immunoassay (ELISA) for the determination of antibodies to HTLV 1 and HTLV -2. Western blot confirmatory testing was done on reactive samples. All donors were also screened for HIV, HBsAg and HCV by rapid kits.

RESULTS

The seroprevalence of HTLV -1 by ELISA was 1.0% and 0.5% by Western Blot among blood donors. A total of 210 healthy blood donors were enrolled. Only 2 (1.0%) blood donors were repeatedly reactive with ELISA test. On confirmatory testing with Western Blot, 1 (0.5%) blood donor was positive for HTLV. All the healthy blood donors were negative for HIV, HbsAg and HCV. None of the 210 blood donors had been previously transfused; as such no association could be established between transfusion history and HTLV positivity among the blood donors.

CONCLUSION

The seroprevalence of HTLV in this environment is low among healthy blood donors.

Authors+Show Affiliations

Department of Haematology and Blood Transfusion Lagos State University, Teaching Hospital, Lagos, Nigeria.Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine, ikeja, Nigeria.Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine, ikeja, Nigeria.Department of Haematology and Immunology, Ben Carson, School of Medicine, Backcok University, Ilisan, Ogun State, Nigeria.Department of Haematology and Blood Transfusion, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine, ikeja, Nigeria.Department of Medicine, Lagos State University, College of Medicine, Ikeja, Nigeria.Oak Hospitals, Ikorodu, Nigeria.Department of Medicine, Lagos State University, College of Medicine, Ikeja, Nigeria.Department of Medicine, University of PortHarcourt, River State, Nigeria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25328597

Citation

Durojaiye, Idris, et al. "Seroprevalence of Human T Lymphotropic Virus Antibodies Among Healthy Blood Donors at a Tertiary Centre in Lagos, Nigeria." The Pan African Medical Journal, vol. 17, 2014, p. 301.
Durojaiye I, Akinbami A, Dosunmu A, et al. Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria. Pan Afr Med J. 2014;17:301.
Durojaiye, I., Akinbami, A., Dosunmu, A., Ajibola, S., Adediran, A., Uche, E., Oshinaike, O., Odesanya, M., Dada, A., & Okunoye, O. (2014). Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria. The Pan African Medical Journal, 17, 301. https://doi.org/10.11604/pamj.2014.17.301.4075
Durojaiye I, et al. Seroprevalence of Human T Lymphotropic Virus Antibodies Among Healthy Blood Donors at a Tertiary Centre in Lagos, Nigeria. Pan Afr Med J. 2014;17:301. PubMed PMID: 25328597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria. AU - Durojaiye,Idris, AU - Akinbami,Akinsegun, AU - Dosunmu,Adedoyin, AU - Ajibola,Sarah, AU - Adediran,Adewumi, AU - Uche,Ebele, AU - Oshinaike,Olajumoke, AU - Odesanya,Majeed, AU - Dada,Akinola, AU - Okunoye,Olaitan, Y1 - 2014/04/21/ PY - 2014/02/22/received PY - 2014/04/13/accepted PY - 2014/10/21/entrez PY - 2014/10/21/pubmed PY - 2015/8/19/medline KW - HTLV KW - Nigeria KW - Seroprevalence KW - healthy blood donors SP - 301 EP - 301 JF - The Pan African medical journal JO - Pan Afr Med J VL - 17 N2 - INTRODUCTION: Transmission of human T-lymphotropic viruses (HTLV) occurs from mother to child, by sexual contact and blood transfusion. Presently, in most centres in Nigeria, there is no routine pre-transfusion screening for HTLV. The study aims to determine the prevalence of HTLV-1 and HTLV-2 among healthy blood donors at a tertiary centre in Lagos. METHODS: A cross-sectional study was carried out at the blood donor clinic of the Lagos State University Teaching Hospital (LASUTH), Ikeja. About 5 mls of venous blood was collected from each subject into a sterile plain bottle after obtaining subject's consent. The serum separated and stored at -200C. Sera were assayed for HTLV by an enzyme-linked immunoassay (ELISA) for the determination of antibodies to HTLV 1 and HTLV -2. Western blot confirmatory testing was done on reactive samples. All donors were also screened for HIV, HBsAg and HCV by rapid kits. RESULTS: The seroprevalence of HTLV -1 by ELISA was 1.0% and 0.5% by Western Blot among blood donors. A total of 210 healthy blood donors were enrolled. Only 2 (1.0%) blood donors were repeatedly reactive with ELISA test. On confirmatory testing with Western Blot, 1 (0.5%) blood donor was positive for HTLV. All the healthy blood donors were negative for HIV, HbsAg and HCV. None of the 210 blood donors had been previously transfused; as such no association could be established between transfusion history and HTLV positivity among the blood donors. CONCLUSION: The seroprevalence of HTLV in this environment is low among healthy blood donors. SN - 1937-8688 UR - https://www.unboundmedicine.com/medline/citation/25328597/Seroprevalence_of_human_T_lymphotropic_virus_antibodies_among_healthy_blood_donors_at_a_tertiary_centre_in_Lagos_Nigeria_ L2 - https://www.panafrican-med-journal.com/content/article/17/301/full/ DB - PRIME DP - Unbound Medicine ER -