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Synthetic cathinones and their rewarding and reinforcing effects in rodents.
Adv Neurosci (Hindawi). 2014 Jun 04; 2014:209875.AN

Abstract

Synthetic cathinones, colloquially referred to as "bath salts", are derivatives of the psychoactive alkaloid cathinone found in Catha edulis (Khat). Since the mid-to-late 2000's, these amphetamine-like psychostimulants have gained popularity amongst drug users due to their potency, low cost, ease of procurement, and constantly evolving chemical structures. Concomitant with their increased use is the emergence of a growing collection of case reports of bizarre and dangerous behaviors, toxicity to numerous organ systems, and death. However, scientific information regarding the abuse liability of these drugs has been relatively slower to materialize. Recently we have published several studies demonstrating that laboratory rodents will readily self-administer the "first generation" synthetic cathinones methylenedioxypyrovalerone (MDPV) and methylone via the intravenous route, in patterns similar to those of methamphetamine. Under progressive ratio schedules of reinforcement, the rank order of reinforcing efficacy of these compounds are MDPV ≥ methamphetamine > methylone. MDPV and methylone, as well as the "second generation" synthetic cathinones α-pyrrolidinovalerophenone (α-PVP) and 4-methylethcathinone (4-MEC), also dose-dependently increase brain reward function. Collectively, these findings indicate that synthetic cathinones have a high abuse and addiction potential and underscore the need for future assessment of the extent and duration of neurotoxicity induced by these emerging drugs of abuse.

Authors+Show Affiliations

Department of Psychology Arizona State University Tempe, Arizona USA.Department of Psychology Arizona State University Tempe, Arizona USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25328910

Citation

Watterson, Lucas R., and M Foster Olive. "Synthetic Cathinones and Their Rewarding and Reinforcing Effects in Rodents." Advances in Neuroscience (Hindawi), vol. 2014, 2014, p. 209875.
Watterson LR, Olive MF. Synthetic cathinones and their rewarding and reinforcing effects in rodents. Adv Neurosci (Hindawi). 2014;2014:209875.
Watterson, L. R., & Olive, M. F. (2014). Synthetic cathinones and their rewarding and reinforcing effects in rodents. Advances in Neuroscience (Hindawi), 2014, 209875.
Watterson LR, Olive MF. Synthetic Cathinones and Their Rewarding and Reinforcing Effects in Rodents. Adv Neurosci (Hindawi). 2014 Jun 4;2014:209875. PubMed PMID: 25328910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthetic cathinones and their rewarding and reinforcing effects in rodents. AU - Watterson,Lucas R, AU - Olive,M Foster, PY - 2014/10/21/entrez PY - 2014/10/21/pubmed PY - 2014/10/21/medline SP - 209875 EP - 209875 JF - Advances in neuroscience (Hindawi) JO - Adv Neurosci (Hindawi) VL - 2014 N2 - Synthetic cathinones, colloquially referred to as "bath salts", are derivatives of the psychoactive alkaloid cathinone found in Catha edulis (Khat). Since the mid-to-late 2000's, these amphetamine-like psychostimulants have gained popularity amongst drug users due to their potency, low cost, ease of procurement, and constantly evolving chemical structures. Concomitant with their increased use is the emergence of a growing collection of case reports of bizarre and dangerous behaviors, toxicity to numerous organ systems, and death. However, scientific information regarding the abuse liability of these drugs has been relatively slower to materialize. Recently we have published several studies demonstrating that laboratory rodents will readily self-administer the "first generation" synthetic cathinones methylenedioxypyrovalerone (MDPV) and methylone via the intravenous route, in patterns similar to those of methamphetamine. Under progressive ratio schedules of reinforcement, the rank order of reinforcing efficacy of these compounds are MDPV ≥ methamphetamine > methylone. MDPV and methylone, as well as the "second generation" synthetic cathinones α-pyrrolidinovalerophenone (α-PVP) and 4-methylethcathinone (4-MEC), also dose-dependently increase brain reward function. Collectively, these findings indicate that synthetic cathinones have a high abuse and addiction potential and underscore the need for future assessment of the extent and duration of neurotoxicity induced by these emerging drugs of abuse. SN - 2356-6787 UR - https://www.unboundmedicine.com/medline/citation/25328910/Synthetic_cathinones_and_their_rewarding_and_reinforcing_effects_in_rodents_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25328910/ DB - PRIME DP - Unbound Medicine ER -
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