Tags

Type your tag names separated by a space and hit enter

In vitro evaluation of three commercial sustained-release papaverine hydrochloride products.
J Pharm Sci. 1978 Apr; 67(4):496-500.JP

Abstract

Three commercial sustained-release papaverine hydrochloride products in the form of microencapsulated pellets were evaluated. Three different dissolution apparatuses were used: a continuous flow apparatus, the USP rotating basket apparatus, and a modified reciprocating basket apparatus. The frequency rate of the reciprocating basket apparatus could be varied from 0 to 31 strokes/min. Salicylic acid compacts were used as a standard to characterize each apparatus. A linear log--log correlation between dissolution rate and apparatus speed or flow rate was obtained. Release of papaverine hydrochloride from the commercial preparations was affected significantly by the pH of the dissolution media but not by the agitation intensity.

Authors

Timko RJ
No affiliation info available
Lordi NG
No affiliation info available

MeSH

Chemistry, PharmaceuticalDelayed-Action PreparationsGastric JuiceHydrogen-Ion ConcentrationPapaverineSolubility

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25329

Citation

Timko, R J., and N G. Lordi. "In Vitro Evaluation of Three Commercial Sustained-release Papaverine Hydrochloride Products." Journal of Pharmaceutical Sciences, vol. 67, no. 4, 1978, pp. 496-500.
Timko RJ, Lordi NG. In vitro evaluation of three commercial sustained-release papaverine hydrochloride products. J Pharm Sci. 1978;67(4):496-500.
Timko, R. J., & Lordi, N. G. (1978). In vitro evaluation of three commercial sustained-release papaverine hydrochloride products. Journal of Pharmaceutical Sciences, 67(4), 496-500.
Timko RJ, Lordi NG. In Vitro Evaluation of Three Commercial Sustained-release Papaverine Hydrochloride Products. J Pharm Sci. 1978;67(4):496-500. PubMed PMID: 25329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro evaluation of three commercial sustained-release papaverine hydrochloride products. AU - Timko,R J, AU - Lordi,N G, PY - 1978/4/1/pubmed PY - 1978/4/1/medline PY - 1978/4/1/entrez SP - 496 EP - 500 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 67 IS - 4 N2 - Three commercial sustained-release papaverine hydrochloride products in the form of microencapsulated pellets were evaluated. Three different dissolution apparatuses were used: a continuous flow apparatus, the USP rotating basket apparatus, and a modified reciprocating basket apparatus. The frequency rate of the reciprocating basket apparatus could be varied from 0 to 31 strokes/min. Salicylic acid compacts were used as a standard to characterize each apparatus. A linear log--log correlation between dissolution rate and apparatus speed or flow rate was obtained. Release of papaverine hydrochloride from the commercial preparations was affected significantly by the pH of the dissolution media but not by the agitation intensity. SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/25329/In_vitro_evaluation_of_three_commercial_sustained_release_papaverine_hydrochloride_products_ DB - PRIME DP - Unbound Medicine ER -