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Melatonin: shedding light on infertility?--A review of the recent literature.
J Ovarian Res. 2014 Oct 21; 7:98.JO

Abstract

In recent years, the negative impact of oxidative stress on fertility has become widely recognised. Several studies have demonstrated its negative effect on the number and quality of retrieved oocytes and embryos following in-vitro fertilisation (IVF). Melatonin, a pineal hormone that regulates circadian rhythms, has also been shown to exhibit unique oxygen scavenging abilities. Some studies have suggested a role for melatonin in gamete biology. Clinical studies also suggest that melatonin supplementation in IVF may lead to better pregnancy rates. Here we present a critical review and summary of the current literature and provide suggestions for future well designed clinical trials.

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Authors+Show Affiliations

Fernando S
MIMR-PHI Institute of Medical Research, 246 Clayton Rd, Clayton, 3168, , Victoria, Australia. shavif@hotmail.com. Monash University, Department of Obstetrics and Gynaecology, Level 5 Monash Medical Centre, 246 Clayton Rd, Clayton, 3168, , Victoria, Australia. shavif@hotmail.com.
Rombauts L
MIMR-PHI Institute of Medical Research, 246 Clayton Rd, Clayton, 3168, , Victoria, Australia. luk.rombauts@monash.edu.au. Monash IVF, 252 Clayton rd, Clayton, 3168, , Victoria, Australia. luk.rombauts@monash.edu.au.

MeSH

AnimalsFertility AgentsFertilization in VitroFree Radical ScavengersHumansInfertilityMelatoninOxidative Stress

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25330986

Clinical Trial Links

Impact of Melatonin on IVF/ICSI Outcomes in Prospective Poor Responders

Citation

Fernando, Shavi, and Luk Rombauts. "Melatonin: Shedding Light On infertility?--A Review of the Recent Literature." Journal of Ovarian Research, vol. 7, 2014, p. 98.
Fernando S, Rombauts L. Melatonin: shedding light on infertility?--A review of the recent literature. J Ovarian Res. 2014;7:98.
Fernando, S., & Rombauts, L. (2014). Melatonin: shedding light on infertility?--A review of the recent literature. Journal of Ovarian Research, 7, 98. https://doi.org/10.1186/s13048-014-0098-y
Fernando S, Rombauts L. Melatonin: Shedding Light On infertility?--A Review of the Recent Literature. J Ovarian Res. 2014 Oct 21;7:98. PubMed PMID: 25330986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin: shedding light on infertility?--A review of the recent literature. AU - Fernando,Shavi, AU - Rombauts,Luk, Y1 - 2014/10/21/ PY - 2014/07/24/received PY - 2014/10/11/accepted PY - 2014/10/22/entrez PY - 2014/10/22/pubmed PY - 2015/10/16/medline SP - 98 EP - 98 JF - Journal of ovarian research JO - J Ovarian Res VL - 7 N2 - In recent years, the negative impact of oxidative stress on fertility has become widely recognised. Several studies have demonstrated its negative effect on the number and quality of retrieved oocytes and embryos following in-vitro fertilisation (IVF). Melatonin, a pineal hormone that regulates circadian rhythms, has also been shown to exhibit unique oxygen scavenging abilities. Some studies have suggested a role for melatonin in gamete biology. Clinical studies also suggest that melatonin supplementation in IVF may lead to better pregnancy rates. Here we present a critical review and summary of the current literature and provide suggestions for future well designed clinical trials. SN - 1757-2215 UR - https://www.unboundmedicine.com/medline/citation/25330986/Melatonin:_shedding_light_on_infertility__A_review_of_the_recent_literature_ DB - PRIME DP - Unbound Medicine ER -