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Nano spray-dried pyrazinamide-L-leucine dry powders, physical properties and feasibility used as dry powder aerosols.
Pharm Dev Technol. 2016; 21(1):68-75.PD

Abstract

OBJECTIVE

The aim of this study was to investigate the effect of adding L-leucine and using an ethanolic solvent on the physicochemical properties and aerodynamic behavior of nano spray-dried pyrazinamide (PZA)-L-leucine powders.

MATERIALS AND METHODS

A nano spray dryer was employed to prepare PZA-L-leucine powders. The physicochemical properties were evaluated using a scanning electron microscope (SEM), differential scanning calorimetry and X-ray diffraction. The Andersen cascade impactor was used to evaluate the in vitro aerosolization performance of the sprayed powders.

RESULTS AND DISCUSSION

The incorporation of L-leucine at 10% improved the percentage fine particle fraction (%FPF) in all ethanolic solvent formulations by up to nearly twofold (20.0-23.4%) compared to the normal spray-dried PZA of (8.8-13.0%). Changes in the particle density and morphology were also observed. The dense solid particles of PZA were completely converted to bulk hollow particles with a thin shell by increasing the L-leucine content up to 50%. Higher ethanol concentration resulted in larger dimensions of the hollow particle but did not directly affect the aerosolization performance. The co-spray dried PZA with 20% L-leucine in a 10% ethanol feed solvent gave the best aerosolization performance (FPF = 33.0%).

CONCLUSIONS

The co-spray dried PZA with a suitable L-leucine content using a nano spray drying technique could be applied to formulate the PZA DPI.

Authors+Show Affiliations

a Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences , Prince of Songkla University , Hat Yai , Songkhla , Thailand and.a Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences , Prince of Songkla University , Hat Yai , Songkhla , Thailand and. b Faculty of Pharmaceutical Sciences, NANOTEC-PSU Excellence Center on Drug Delivery System , Prince of Songkla University , Hat Yai , Songkhla , Thailand.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25331092

Citation

Kaewjan, Kanogwan, and Teerapol Srichana. "Nano Spray-dried pyrazinamide-L-leucine Dry Powders, Physical Properties and Feasibility Used as Dry Powder Aerosols." Pharmaceutical Development and Technology, vol. 21, no. 1, 2016, pp. 68-75.
Kaewjan K, Srichana T. Nano spray-dried pyrazinamide-L-leucine dry powders, physical properties and feasibility used as dry powder aerosols. Pharm Dev Technol. 2016;21(1):68-75.
Kaewjan, K., & Srichana, T. (2016). Nano spray-dried pyrazinamide-L-leucine dry powders, physical properties and feasibility used as dry powder aerosols. Pharmaceutical Development and Technology, 21(1), 68-75. https://doi.org/10.3109/10837450.2014.971373
Kaewjan K, Srichana T. Nano Spray-dried pyrazinamide-L-leucine Dry Powders, Physical Properties and Feasibility Used as Dry Powder Aerosols. Pharm Dev Technol. 2016;21(1):68-75. PubMed PMID: 25331092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nano spray-dried pyrazinamide-L-leucine dry powders, physical properties and feasibility used as dry powder aerosols. AU - Kaewjan,Kanogwan, AU - Srichana,Teerapol, Y1 - 2014/10/21/ PY - 2014/10/22/entrez PY - 2014/10/22/pubmed PY - 2016/10/26/medline KW - Andersen cascade impactor KW - dry powder inhaler KW - lung delivery KW - nano spray dryer KW - tuberculosis SP - 68 EP - 75 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 21 IS - 1 N2 - OBJECTIVE: The aim of this study was to investigate the effect of adding L-leucine and using an ethanolic solvent on the physicochemical properties and aerodynamic behavior of nano spray-dried pyrazinamide (PZA)-L-leucine powders. MATERIALS AND METHODS: A nano spray dryer was employed to prepare PZA-L-leucine powders. The physicochemical properties were evaluated using a scanning electron microscope (SEM), differential scanning calorimetry and X-ray diffraction. The Andersen cascade impactor was used to evaluate the in vitro aerosolization performance of the sprayed powders. RESULTS AND DISCUSSION: The incorporation of L-leucine at 10% improved the percentage fine particle fraction (%FPF) in all ethanolic solvent formulations by up to nearly twofold (20.0-23.4%) compared to the normal spray-dried PZA of (8.8-13.0%). Changes in the particle density and morphology were also observed. The dense solid particles of PZA were completely converted to bulk hollow particles with a thin shell by increasing the L-leucine content up to 50%. Higher ethanol concentration resulted in larger dimensions of the hollow particle but did not directly affect the aerosolization performance. The co-spray dried PZA with 20% L-leucine in a 10% ethanol feed solvent gave the best aerosolization performance (FPF = 33.0%). CONCLUSIONS: The co-spray dried PZA with a suitable L-leucine content using a nano spray drying technique could be applied to formulate the PZA DPI. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/25331092/Nano_spray_dried_pyrazinamide_L_leucine_dry_powders_physical_properties_and_feasibility_used_as_dry_powder_aerosols_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2014.971373 DB - PRIME DP - Unbound Medicine ER -