TY - JOUR T1 - Relationship between cobalamin-dependent metabolites and both serum albumin and alpha1 -proteinase inhibitor concentrations in hypocobalaminemic dogs of 7 different breeds. AU - Grützner,Niels, AU - Suchodolski,Jan S, AU - Steiner,Jörg M, Y1 - 2014/10/20/ PY - 2014/10/22/entrez PY - 2014/10/22/pubmed PY - 2015/12/15/medline KW - Antitrypsin KW - homocysteine KW - methylmalonic acid KW - vitamin B12 SP - 561 EP - 6 JF - Veterinary clinical pathology JO - Vet Clin Pathol VL - 43 IS - 4 N2 - BACKGROUND: Increased serum concentrations of homocysteine (HCY) and methylmalonic acid (MMA), the 2 main cobalamin-dependent metabolites, as well as decreased serum albumin and canine alpha1 -proteinase inhibitor (cα1 -PI) concentrations have previously been described in hypocobalaminemic dogs with gastrointestinal disease. However, no studies have been conducted to evaluate potential relationships between these serum biomarkers. OBJECTIVE: The aim of this study was to evaluate the relationship between HCY and MMA, 2 cobalamin-dependent metabolites, and both serum albumin and cα1 -PI concentrations in hypocobalaminemic dogs. METHODS: Serum samples from 285 dogs including 7 different breeds (Beagle, Boxer, Cocker Spaniel, German Shepherd, Labrador Retriever, Chinese Shar-Pei, and Yorkshire Terrier) with hypocobalaminemia were used. Serum HCY, MMA, albumin, and cα1 -PI concentrations were determined. RESULTS: There was a significant correlation between serum HCY and albumin concentrations, as well as serum HCY and cα1 -PI concentrations (ρ = 0.62 and ρ = 0.37, respectively; P < .0001). No correlations were observed between serum MMA and albumin concentrations, or cα1 -PI concentrations (ρ = 0.01 and ρ = 0.08, respectively; P > .05). In addition, significant breed-specific correlations were observed between serum MMA and albumin concentrations in German Shepherds, and serum HCY and MMA concentrations in Chinese Shar-Peis with hypocobalaminemia. CONCLUSIONS: This study shows a correlation between serum albumin and cα1 -PI and HCY concentrations, but not with serum MMA concentration in dogs with hypocobalaminemia. In addition, significant breed-specific correlations were observed between serum MMA and albumin concentrations in German Shepherds, as well as serum HCY and MMA concentrations in Chinese Shar-Peis, emphasizing the unique metabolic interactions in those dog breeds affected by hypocobalaminemia. SN - 1939-165X UR - https://www.unboundmedicine.com/medline/citation/25331651/Relationship_between_cobalamin_dependent_metabolites_and_both_serum_albumin_and_alpha1__proteinase_inhibitor_concentrations_in_hypocobalaminemic_dogs_of_7_different_breeds_ DB - PRIME DP - Unbound Medicine ER -