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Fish and fatty acid consumption and the risk of hearing loss in women.
Am J Clin Nutr 2014; 100(5):1371-7AJ

Abstract

BACKGROUND

Acquired hearing loss is common and often disabling, yet limited prospective data exist on potentially modifiable risk factors. Evidence suggests that higher intake of fish and long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be associated with a lower risk of hearing loss, but prospective information on these relations is limited.

OBJECTIVE

We prospectively examined the independent associations between consumption of total and specific types of fish, long-chain omega-3 PUFAs, and self-reported hearing loss in women.

DESIGN

Data were from the Nurses' Health Study II, a prospective cohort study. The independent associations between consumption of fish and long-chain omega-3 PUFAs and self-reported hearing loss were examined in 65,215 women followed from 1991 to 2009. Baseline and updated information was obtained from validated biennial questionnaires. Cox proportional hazards regression models were used to estimate multivariable-adjusted RRs and 95% CIs.

RESULTS

After 1,038,093 person-years of follow-up, 11,606 cases of incident hearing loss were reported. Consumption of 2 or more servings of fish per week was associated with a lower risk of hearing loss. In comparison with women who rarely consumed fish (<1 serving/mo), the multivariable-adjusted RR for hearing loss among women who consumed 2-4 servings of fish per week was 0.80 (95% CI: 0.74, 0.88) (P-trend < 0.001). When examined individually, higher consumption of each specific fish type was inversely associated with risk (P-trend ≤ 0.04). Higher intake of long-chain omega-3 PUFAs was also inversely associated with risk of hearing loss. In comparison with women in the lowest quintile of intake of long-chain omega-3 PUFAs, the multivariable-adjusted RR for hearing loss among women in the highest quintile was 0.85 (95% CI: 0.80, 0.91) and among women in the highest decile was 0.78 (95% CI: 0.72, 0.85) (P-trend < 0.001).

CONCLUSION

Regular fish consumption and higher intake of long-chain omega-3 PUFAs are associated with lower risk of hearing loss in women.

Authors+Show Affiliations

From the Channing Division of Network Medicine (SGC, MW, EBR, and GCC) and the Renal Division (GCC), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Nashville, TN (RDE); and the Departments of Biostatistics (MW) and Epidemiology (MW, EBR, GCC), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine (SGC, MW, EBR, and GCC) and the Renal Division (GCC), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Nashville, TN (RDE); and the Departments of Biostatistics (MW) and Epidemiology (MW, EBR, GCC), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine (SGC, MW, EBR, and GCC) and the Renal Division (GCC), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Nashville, TN (RDE); and the Departments of Biostatistics (MW) and Epidemiology (MW, EBR, GCC), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine (SGC, MW, EBR, and GCC) and the Renal Division (GCC), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Nashville, TN (RDE); and the Departments of Biostatistics (MW) and Epidemiology (MW, EBR, GCC), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine (SGC, MW, EBR, and GCC) and the Renal Division (GCC), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Nashville, TN (RDE); and the Departments of Biostatistics (MW) and Epidemiology (MW, EBR, GCC), Harvard School of Public Health, Boston, MA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25332335

Citation

Curhan, Sharon G., et al. "Fish and Fatty Acid Consumption and the Risk of Hearing Loss in Women." The American Journal of Clinical Nutrition, vol. 100, no. 5, 2014, pp. 1371-7.
Curhan SG, Eavey RD, Wang M, et al. Fish and fatty acid consumption and the risk of hearing loss in women. Am J Clin Nutr. 2014;100(5):1371-7.
Curhan, S. G., Eavey, R. D., Wang, M., Rimm, E. B., & Curhan, G. C. (2014). Fish and fatty acid consumption and the risk of hearing loss in women. The American Journal of Clinical Nutrition, 100(5), pp. 1371-7. doi:10.3945/ajcn.114.091819.
Curhan SG, et al. Fish and Fatty Acid Consumption and the Risk of Hearing Loss in Women. Am J Clin Nutr. 2014;100(5):1371-7. PubMed PMID: 25332335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish and fatty acid consumption and the risk of hearing loss in women. AU - Curhan,Sharon G, AU - Eavey,Roland D, AU - Wang,Molin, AU - Rimm,Eric B, AU - Curhan,Gary C, Y1 - 2014/09/10/ PY - 2014/10/22/entrez PY - 2014/10/22/pubmed PY - 2015/2/24/medline SP - 1371 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 100 IS - 5 N2 - BACKGROUND: Acquired hearing loss is common and often disabling, yet limited prospective data exist on potentially modifiable risk factors. Evidence suggests that higher intake of fish and long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be associated with a lower risk of hearing loss, but prospective information on these relations is limited. OBJECTIVE: We prospectively examined the independent associations between consumption of total and specific types of fish, long-chain omega-3 PUFAs, and self-reported hearing loss in women. DESIGN: Data were from the Nurses' Health Study II, a prospective cohort study. The independent associations between consumption of fish and long-chain omega-3 PUFAs and self-reported hearing loss were examined in 65,215 women followed from 1991 to 2009. Baseline and updated information was obtained from validated biennial questionnaires. Cox proportional hazards regression models were used to estimate multivariable-adjusted RRs and 95% CIs. RESULTS: After 1,038,093 person-years of follow-up, 11,606 cases of incident hearing loss were reported. Consumption of 2 or more servings of fish per week was associated with a lower risk of hearing loss. In comparison with women who rarely consumed fish (<1 serving/mo), the multivariable-adjusted RR for hearing loss among women who consumed 2-4 servings of fish per week was 0.80 (95% CI: 0.74, 0.88) (P-trend < 0.001). When examined individually, higher consumption of each specific fish type was inversely associated with risk (P-trend ≤ 0.04). Higher intake of long-chain omega-3 PUFAs was also inversely associated with risk of hearing loss. In comparison with women in the lowest quintile of intake of long-chain omega-3 PUFAs, the multivariable-adjusted RR for hearing loss among women in the highest quintile was 0.85 (95% CI: 0.80, 0.91) and among women in the highest decile was 0.78 (95% CI: 0.72, 0.85) (P-trend < 0.001). CONCLUSION: Regular fish consumption and higher intake of long-chain omega-3 PUFAs are associated with lower risk of hearing loss in women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/25332335/Fish_and_fatty_acid_consumption_and_the_risk_of_hearing_loss_in_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.114.091819 DB - PRIME DP - Unbound Medicine ER -