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Cell proliferation kinetics of epidermis, hair follicles, and sebaceous glands of cocker spaniels with idiopathic seborrhea.
Am J Vet Res. 1989 Nov; 50(11):1918-22.AJ

Abstract

Cell proliferation kinetic values were established for the epidermis, hair follicle epithelium, and sebaceous glands of 8 Cocker Spaniels with primary idiopathic seborrhea. Values were established by intradermal pulse labeling injections of tritiated thymidine followed by cutaneous biopsy and autoradiography. The epidermal basal cell-labeling index was 4.96 +/- 0.97%, and the epidermal nucleated cell-labeling index was 3.33 +/- 0.71%. Calculated epidermal cell renewal time for the viable layers of the epidermis was 7.85 +/- 1.80 days. The hair follicle infundibulum basal cell-labeling index was 5.48 +/- 2.01%, and the sebaceous gland basal cell-labeling index was 5.94 +/- 4.15%. When compared with previously reported cell kinetic values for Cocker Spaniels and Beagles with healthy skin, these data indicate accelerated cellular proliferation in all 3 cutaneous structures in seborrheic Cocker Spaniels.

Authors+Show Affiliations

Kwochka KW
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Rademakers AM
No affiliation info available

MeSH

AnimalsAutoradiographyCell DivisionDermatitis, SeborrheicDog DiseasesDogsEpidermisEpitheliumFemaleHairKineticsMaleSebaceous Glands

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2533468

Citation

Kwochka, K W., and A M. Rademakers. "Cell Proliferation Kinetics of Epidermis, Hair Follicles, and Sebaceous Glands of Cocker Spaniels With Idiopathic Seborrhea." American Journal of Veterinary Research, vol. 50, no. 11, 1989, pp. 1918-22.
Kwochka KW, Rademakers AM. Cell proliferation kinetics of epidermis, hair follicles, and sebaceous glands of cocker spaniels with idiopathic seborrhea. Am J Vet Res. 1989;50(11):1918-22.
Kwochka, K. W., & Rademakers, A. M. (1989). Cell proliferation kinetics of epidermis, hair follicles, and sebaceous glands of cocker spaniels with idiopathic seborrhea. American Journal of Veterinary Research, 50(11), 1918-22.
Kwochka KW, Rademakers AM. Cell Proliferation Kinetics of Epidermis, Hair Follicles, and Sebaceous Glands of Cocker Spaniels With Idiopathic Seborrhea. Am J Vet Res. 1989;50(11):1918-22. PubMed PMID: 2533468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell proliferation kinetics of epidermis, hair follicles, and sebaceous glands of cocker spaniels with idiopathic seborrhea. AU - Kwochka,K W, AU - Rademakers,A M, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 1918 EP - 22 JF - American journal of veterinary research JO - Am J Vet Res VL - 50 IS - 11 N2 - Cell proliferation kinetic values were established for the epidermis, hair follicle epithelium, and sebaceous glands of 8 Cocker Spaniels with primary idiopathic seborrhea. Values were established by intradermal pulse labeling injections of tritiated thymidine followed by cutaneous biopsy and autoradiography. The epidermal basal cell-labeling index was 4.96 +/- 0.97%, and the epidermal nucleated cell-labeling index was 3.33 +/- 0.71%. Calculated epidermal cell renewal time for the viable layers of the epidermis was 7.85 +/- 1.80 days. The hair follicle infundibulum basal cell-labeling index was 5.48 +/- 2.01%, and the sebaceous gland basal cell-labeling index was 5.94 +/- 4.15%. When compared with previously reported cell kinetic values for Cocker Spaniels and Beagles with healthy skin, these data indicate accelerated cellular proliferation in all 3 cutaneous structures in seborrheic Cocker Spaniels. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/2533468/Cell_proliferation_kinetics_of_epidermis_hair_follicles_and_sebaceous_glands_of_cocker_spaniels_with_idiopathic_seborrhea_ DB - PRIME DP - Unbound Medicine ER -