Tags

Type your tag names separated by a space and hit enter

Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset.
Int J Geriatr Psychiatry 2015; 30(7):720-8IJ

Abstract

BACKGROUND

We examined patients with mild cognitive impairment (MCI) with a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect of beta-amyloid (Aβ) pathology on the pathology of GD by using [(18)F]florbetapir PET.

METHODS

Thirty-three elderly patients (76.7 ± 4.2 years) and 22 healthy controls (HC; 72.0 ± 4.5 years, average ± SD) were examined by [(18)F]florbetapir positron emission tomography (PET) to quantify the standard uptake value ratio (SUVR) as the degree of amyloid accumulation, by MRI to determine the degree of atrophy, by Mini-Mental State Examination for cognitive functions, and by Geriatric Depression Scale for the severity of depression, and by Clinical Dementia Rating for activity of daily living (ADL). The cut-off value of 1.08 for SUVR was defined as Aβ-positive.

RESULTS

Of the patients and HC, 39.4% and 27.3%, respectively, were beta-amyloid-positive. The onset age of GD was significantly correlated with SUVR (r = 0.44, p < 0.01). Compared to patients without Aβ (GD-Aβ), patients with Aβ (GD + Aβ) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. GD + Aβ had significantly older average ± SD age at onset of GD (73.6 ± 7.1 versus 58.7 ± 17.8, p < 0.01) and significantly shorter average ± SD time between onset of GD and PET scan day (3.1 ± 5.2 years versus 18.1 ± 18.6 years, p < 0.001) than GD-Aβ.

CONCLUSIONS

Our results showed that the rate of Aβ positivity was higher in late-onset GD and that onset-age was associated with SUVR, suggesting that the later the onset of GD, the more Aβ pathology affected its onset.

Authors+Show Affiliations

Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.Clinical Imaging Center for Healthcare, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.Department of Radiology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.Department of Pharmacology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25335941

Citation

Tateno, Amane, et al. "Amyloid Imaging With [(18)F]florbetapir in Geriatric Depression: Early-onset Versus Late-onset." International Journal of Geriatric Psychiatry, vol. 30, no. 7, 2015, pp. 720-8.
Tateno A, Sakayori T, Higuchi M, et al. Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset. Int J Geriatr Psychiatry. 2015;30(7):720-8.
Tateno, A., Sakayori, T., Higuchi, M., Suhara, T., Ishihara, K., Kumita, S., ... Okubo, Y. (2015). Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset. International Journal of Geriatric Psychiatry, 30(7), pp. 720-8. doi:10.1002/gps.4215.
Tateno A, et al. Amyloid Imaging With [(18)F]florbetapir in Geriatric Depression: Early-onset Versus Late-onset. Int J Geriatr Psychiatry. 2015;30(7):720-8. PubMed PMID: 25335941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset. AU - Tateno,Amane, AU - Sakayori,Takeshi, AU - Higuchi,Makoto, AU - Suhara,Tetsuya, AU - Ishihara,Keiichi, AU - Kumita,Shinichiro, AU - Suzuki,Hidenori, AU - Okubo,Yoshiro, Y1 - 2014/10/21/ PY - 2014/06/16/received PY - 2014/08/19/revised PY - 2014/08/19/accepted PY - 2014/10/23/entrez PY - 2014/10/23/pubmed PY - 2016/3/8/medline KW - Alzheimer's disease KW - beta-amyloid KW - geriatric depression KW - positron emission tomography SP - 720 EP - 8 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 30 IS - 7 N2 - BACKGROUND: We examined patients with mild cognitive impairment (MCI) with a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect of beta-amyloid (Aβ) pathology on the pathology of GD by using [(18)F]florbetapir PET. METHODS: Thirty-three elderly patients (76.7 ± 4.2 years) and 22 healthy controls (HC; 72.0 ± 4.5 years, average ± SD) were examined by [(18)F]florbetapir positron emission tomography (PET) to quantify the standard uptake value ratio (SUVR) as the degree of amyloid accumulation, by MRI to determine the degree of atrophy, by Mini-Mental State Examination for cognitive functions, and by Geriatric Depression Scale for the severity of depression, and by Clinical Dementia Rating for activity of daily living (ADL). The cut-off value of 1.08 for SUVR was defined as Aβ-positive. RESULTS: Of the patients and HC, 39.4% and 27.3%, respectively, were beta-amyloid-positive. The onset age of GD was significantly correlated with SUVR (r = 0.44, p < 0.01). Compared to patients without Aβ (GD-Aβ), patients with Aβ (GD + Aβ) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. GD + Aβ had significantly older average ± SD age at onset of GD (73.6 ± 7.1 versus 58.7 ± 17.8, p < 0.01) and significantly shorter average ± SD time between onset of GD and PET scan day (3.1 ± 5.2 years versus 18.1 ± 18.6 years, p < 0.001) than GD-Aβ. CONCLUSIONS: Our results showed that the rate of Aβ positivity was higher in late-onset GD and that onset-age was associated with SUVR, suggesting that the later the onset of GD, the more Aβ pathology affected its onset. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/25335941/Amyloid_imaging_with_[_18_F]florbetapir_in_geriatric_depression:_early_onset_versus_late_onset_ L2 - https://doi.org/10.1002/gps.4215 DB - PRIME DP - Unbound Medicine ER -