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Iodine nutrition and thyroid diseases in Chengdu, China: an epidemiological study.
QJM. 2015 May; 108(5):379-85.QJM

Abstract

OBJECTIVE

To assess the iodine nutritional status and investigate the prevalence of thyroid diseases in a community population in Chengdu, China.

METHODS

Eighty school-age children were randomly selected for measurements of urinary iodine concentration. A total of 1500 residents over the age of 18 who had lived in Chengdu for more than 5 years were selected by stratified cluster sampling. Serum thyroid hormone concentrations and thyroid autoantibodies were measured, and thyroid ultrasonography was performed.

RESULTS

The median urine iodine concentration was 184 µg/l in school-age children. The prevalence of clinical hyperthyroidism, subclinical hyperthyroidism, clinical hypothyroidism and subclinical hypothyroidism was 0.97%, 1.95%, 0.90% and 5.55%, respectively. The prevalence of thyroid autoantibodies and thyroid nodules was 15.82% and 16.87%, respectively. The prevalence of clinical hyper- and hypothyroidism was greater in females than in males (P < 0.05). The prevalence of subclinical hyper- and hypothyroidism, thyroid nodules and thyroid autoantibodies increased significantly with age (P < 0.05). The rate of new abnormal TSH was 9.37%, and the average serum Thyroid Stimulating Hormone (TSH) concentrations increased with age. When TSH >0.71 mU/l, the prevalence of positive TPOAb and/or TgAb increased significantly with rising concentrations of TSH (P < 0.05); however, the prevalence of thyroid nodules did not increase with escalating concentrations of TSH (P = 0.09).

CONCLUSION

Subclinical thyroid diseases, especially subclinical hypothyroidism and thyroid nodules, are common in an iodine sufficient area. Females and the elderly might benefit from routine screening for thyroid diseases, followed by appropriate detection and treatment.

Authors+Show Affiliations

From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China.From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China.From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China sansan1880@126.com.From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China.From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China.From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China.From the Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, Department of Geriatrics Medicine of Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, China and Department of General Medicine, Yulin Community Health Service Center, Wuhou District, Chengdu, Sichuan 610041, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25336254

Citation

Yan, Y R., et al. "Iodine Nutrition and Thyroid Diseases in Chengdu, China: an Epidemiological Study." QJM : Monthly Journal of the Association of Physicians, vol. 108, no. 5, 2015, pp. 379-85.
Yan YR, Liu Y, Huang H, et al. Iodine nutrition and thyroid diseases in Chengdu, China: an epidemiological study. QJM. 2015;108(5):379-85.
Yan, Y. R., Liu, Y., Huang, H., Lv, Q. G., Gao, X. L., Jiang, J., & Tong, N. W. (2015). Iodine nutrition and thyroid diseases in Chengdu, China: an epidemiological study. QJM : Monthly Journal of the Association of Physicians, 108(5), 379-85. https://doi.org/10.1093/qjmed/hcu216
Yan YR, et al. Iodine Nutrition and Thyroid Diseases in Chengdu, China: an Epidemiological Study. QJM. 2015;108(5):379-85. PubMed PMID: 25336254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iodine nutrition and thyroid diseases in Chengdu, China: an epidemiological study. AU - Yan,Y R, AU - Liu,Y, AU - Huang,H, AU - Lv,Q G, AU - Gao,X L, AU - Jiang,J, AU - Tong,N W, Y1 - 2014/10/21/ PY - 2014/08/06/received PY - 2014/10/23/entrez PY - 2014/10/23/pubmed PY - 2016/1/23/medline SP - 379 EP - 85 JF - QJM : monthly journal of the Association of Physicians JO - QJM VL - 108 IS - 5 N2 - OBJECTIVE: To assess the iodine nutritional status and investigate the prevalence of thyroid diseases in a community population in Chengdu, China. METHODS: Eighty school-age children were randomly selected for measurements of urinary iodine concentration. A total of 1500 residents over the age of 18 who had lived in Chengdu for more than 5 years were selected by stratified cluster sampling. Serum thyroid hormone concentrations and thyroid autoantibodies were measured, and thyroid ultrasonography was performed. RESULTS: The median urine iodine concentration was 184 µg/l in school-age children. The prevalence of clinical hyperthyroidism, subclinical hyperthyroidism, clinical hypothyroidism and subclinical hypothyroidism was 0.97%, 1.95%, 0.90% and 5.55%, respectively. The prevalence of thyroid autoantibodies and thyroid nodules was 15.82% and 16.87%, respectively. The prevalence of clinical hyper- and hypothyroidism was greater in females than in males (P < 0.05). The prevalence of subclinical hyper- and hypothyroidism, thyroid nodules and thyroid autoantibodies increased significantly with age (P < 0.05). The rate of new abnormal TSH was 9.37%, and the average serum Thyroid Stimulating Hormone (TSH) concentrations increased with age. When TSH >0.71 mU/l, the prevalence of positive TPOAb and/or TgAb increased significantly with rising concentrations of TSH (P < 0.05); however, the prevalence of thyroid nodules did not increase with escalating concentrations of TSH (P = 0.09). CONCLUSION: Subclinical thyroid diseases, especially subclinical hypothyroidism and thyroid nodules, are common in an iodine sufficient area. Females and the elderly might benefit from routine screening for thyroid diseases, followed by appropriate detection and treatment. SN - 1460-2393 UR - https://www.unboundmedicine.com/medline/citation/25336254/Iodine_nutrition_and_thyroid_diseases_in_Chengdu_China:_an_epidemiological_study_ L2 - https://academic.oup.com/qjmed/article-lookup/doi/10.1093/qjmed/hcu216 DB - PRIME DP - Unbound Medicine ER -