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Influenza vaccine prevents medically attended influenza-associated acute respiratory illness in adults aged ≥50 years.
J Infect Dis 2015; 211(7):1045-50JI

Abstract

BACKGROUND

There are few estimates of effectiveness influenza vaccine in preventing serious outcomes due to influenza in older adults.

METHODS

Adults aged ≥50 years who sought medical care for acute respiratory illness were enrolled. A nose/throat swab was tested for influenza virus by reverse transcription-polymerase chain reaction. Clinical and demographic data were collected, including verification of receipt of trivalent inactivated influenza vaccination (IIV-3). Adjusted odds ratios were estimated by multivariable logistic regression models with an L1 penalty on all covariates except vaccination status.

RESULTS

A total of 1047 subjects were enrolled from November through April during 5 influenza seasons during 2006-2012, excluding the 2009-2010 season. Of those enrolled, 927 (88%) had complete influenza virus testing, vaccination status, and demographic data obtained. Of 86 (9.3%) influenza virus-positive patients, 47 (55%) were vaccinated. Of 841 influenza virus-negative patients, 646 (76.8%) were vaccinated. Over 5 influenza seasons, IIV-3 was 58.4% effective (95% confidence interval [CI], 37.0%-75.6%) for the prevention of medically attended laboratory-confirmed influenza illness in adults aged ≥50 years and 58.4% effective (95% CI, 7.9%-81.1%) in adults aged ≥65 years.

CONCLUSIONS

Influenza vaccine was moderately effective in preventing influenza-associated medical care visits in older adults.

Authors+Show Affiliations

Department of Biostatistics Department of Biomedical Informatics, Vanderbilt University Medical Center.Department of Preventive Medicine Department of Medicine Department of Mid-South Geriatric Research Education and Clinical Center Department of Clinical Research Center of Excellence, VA Tennessee Valley Health Care System, Nashville, Tennessee.Department of Biostatistics.Department of Biostatistics.Department of Pediatrics Department of Microbiology and Immunology.Department of Pediatrics.Department of Medicine.

Pub Type(s)

Evaluation Studies
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25336724

Citation

Chen, Qingxia, et al. "Influenza Vaccine Prevents Medically Attended Influenza-associated Acute Respiratory Illness in Adults Aged ≥50 Years." The Journal of Infectious Diseases, vol. 211, no. 7, 2015, pp. 1045-50.
Chen Q, Griffin MR, Nian H, et al. Influenza vaccine prevents medically attended influenza-associated acute respiratory illness in adults aged ≥50 years. J Infect Dis. 2015;211(7):1045-50.
Chen, Q., Griffin, M. R., Nian, H., Zhu, Y., Williams, J. V., Edwards, K. M., & Talbot, H. K. (2015). Influenza vaccine prevents medically attended influenza-associated acute respiratory illness in adults aged ≥50 years. The Journal of Infectious Diseases, 211(7), pp. 1045-50. doi:10.1093/infdis/jiu578.
Chen Q, et al. Influenza Vaccine Prevents Medically Attended Influenza-associated Acute Respiratory Illness in Adults Aged ≥50 Years. J Infect Dis. 2015 Apr 1;211(7):1045-50. PubMed PMID: 25336724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccine prevents medically attended influenza-associated acute respiratory illness in adults aged ≥50 years. AU - Chen,Qingxia, AU - Griffin,Marie R, AU - Nian,Hui, AU - Zhu,Yuwei, AU - Williams,John V, AU - Edwards,Kathryn M, AU - Talbot,H Keipp, Y1 - 2014/10/21/ PY - 2014/10/23/entrez PY - 2014/10/23/pubmed PY - 2015/5/27/medline KW - control-negative KW - elderly KW - influenza vaccine effectiveness KW - older adults SP - 1045 EP - 50 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 211 IS - 7 N2 - BACKGROUND: There are few estimates of effectiveness influenza vaccine in preventing serious outcomes due to influenza in older adults. METHODS: Adults aged ≥50 years who sought medical care for acute respiratory illness were enrolled. A nose/throat swab was tested for influenza virus by reverse transcription-polymerase chain reaction. Clinical and demographic data were collected, including verification of receipt of trivalent inactivated influenza vaccination (IIV-3). Adjusted odds ratios were estimated by multivariable logistic regression models with an L1 penalty on all covariates except vaccination status. RESULTS: A total of 1047 subjects were enrolled from November through April during 5 influenza seasons during 2006-2012, excluding the 2009-2010 season. Of those enrolled, 927 (88%) had complete influenza virus testing, vaccination status, and demographic data obtained. Of 86 (9.3%) influenza virus-positive patients, 47 (55%) were vaccinated. Of 841 influenza virus-negative patients, 646 (76.8%) were vaccinated. Over 5 influenza seasons, IIV-3 was 58.4% effective (95% confidence interval [CI], 37.0%-75.6%) for the prevention of medically attended laboratory-confirmed influenza illness in adults aged ≥50 years and 58.4% effective (95% CI, 7.9%-81.1%) in adults aged ≥65 years. CONCLUSIONS: Influenza vaccine was moderately effective in preventing influenza-associated medical care visits in older adults. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/25336724/Influenza_vaccine_prevents_medically_attended_influenza_associated_acute_respiratory_illness_in_adults_aged_≥50_years_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiu578 DB - PRIME DP - Unbound Medicine ER -