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Preexisting neutralizing antibody responses distinguish clinically inapparent and apparent dengue virus infections in a Sri Lankan pediatric cohort.
J Infect Dis. 2015 Feb 15; 211(4):590-9.JI

Abstract

Dengue viruses (DENVs) are mosquito-borne flaviviruses that infect humans. The clinical presentation of DENV infection ranges from inapparent infection to dengue hemorrhagic fever and dengue shock syndrome. We analyzed samples from a pediatric dengue cohort study in Sri Lanka to explore whether antibody responses differentiated clinically apparent infections from clinically inapparent infections. In DENV-naive individuals exposed to primary DENV infections, we observed no difference in the quantity or quality of acquired antibodies between inapparent and apparent infections. Children who experienced primary infections had broad, serotype-cross-neutralizing antibody responses that narrowed in breadth to a single serotype over a 12-month period after infection. In DENV immune children who were experiencing a repeat infection, we observed a strong association between preexisting neutralizing antibodies and clinical outcome. Notably, children with preexisting monospecific neutralizing antibody responses were more likely to develop fever than children with cross-neutralizing responses. Preexisting DENV neutralizing antibodies are correlated with protection from dengue disease.

Authors+Show Affiliations

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill.Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill Centre of Pathogen Evolution, University of Cambridge, United Kingdom.Epidemiology Unit, Ministry of Health.Epidemiology Unit, Ministry of Health.Genetech Research Institute, Colombo, Sri Lanka.Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25336728

Citation

Corbett, Kizzmekia S., et al. "Preexisting Neutralizing Antibody Responses Distinguish Clinically Inapparent and Apparent Dengue Virus Infections in a Sri Lankan Pediatric Cohort." The Journal of Infectious Diseases, vol. 211, no. 4, 2015, pp. 590-9.
Corbett KS, Katzelnick L, Tissera H, et al. Preexisting neutralizing antibody responses distinguish clinically inapparent and apparent dengue virus infections in a Sri Lankan pediatric cohort. J Infect Dis. 2015;211(4):590-9.
Corbett, K. S., Katzelnick, L., Tissera, H., Amerasinghe, A., de Silva, A. D., & de Silva, A. M. (2015). Preexisting neutralizing antibody responses distinguish clinically inapparent and apparent dengue virus infections in a Sri Lankan pediatric cohort. The Journal of Infectious Diseases, 211(4), 590-9. https://doi.org/10.1093/infdis/jiu481
Corbett KS, et al. Preexisting Neutralizing Antibody Responses Distinguish Clinically Inapparent and Apparent Dengue Virus Infections in a Sri Lankan Pediatric Cohort. J Infect Dis. 2015 Feb 15;211(4):590-9. PubMed PMID: 25336728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preexisting neutralizing antibody responses distinguish clinically inapparent and apparent dengue virus infections in a Sri Lankan pediatric cohort. AU - Corbett,Kizzmekia S, AU - Katzelnick,Leah, AU - Tissera,Hasitha, AU - Amerasinghe,Ananda, AU - de Silva,Aruna Dharshan, AU - de Silva,Aravinda M, Y1 - 2014/10/21/ PY - 2014/10/23/entrez PY - 2014/10/23/pubmed PY - 2015/4/17/medline KW - Sri Lanka KW - dengue fever KW - dengue virus KW - inapparent dengue KW - neutralizing antibody SP - 590 EP - 9 JF - The Journal of infectious diseases JO - J Infect Dis VL - 211 IS - 4 N2 - Dengue viruses (DENVs) are mosquito-borne flaviviruses that infect humans. The clinical presentation of DENV infection ranges from inapparent infection to dengue hemorrhagic fever and dengue shock syndrome. We analyzed samples from a pediatric dengue cohort study in Sri Lanka to explore whether antibody responses differentiated clinically apparent infections from clinically inapparent infections. In DENV-naive individuals exposed to primary DENV infections, we observed no difference in the quantity or quality of acquired antibodies between inapparent and apparent infections. Children who experienced primary infections had broad, serotype-cross-neutralizing antibody responses that narrowed in breadth to a single serotype over a 12-month period after infection. In DENV immune children who were experiencing a repeat infection, we observed a strong association between preexisting neutralizing antibodies and clinical outcome. Notably, children with preexisting monospecific neutralizing antibody responses were more likely to develop fever than children with cross-neutralizing responses. Preexisting DENV neutralizing antibodies are correlated with protection from dengue disease. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/25336728/Preexisting_neutralizing_antibody_responses_distinguish_clinically_inapparent_and_apparent_dengue_virus_infections_in_a_Sri_Lankan_pediatric_cohort_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiu481 DB - PRIME DP - Unbound Medicine ER -