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Changes in adipose tissue depots and metabolic markers following a 1-year diet and exercise intervention in overweight and obese patients with type 2 diabetes.
Diabetes Care. 2014 Dec; 37(12):3325-32.DC

Abstract

OBJECTIVE

We aim to characterize the effects on total body fat and distribution of a 1-year intensive lifestyle intervention (ILI) for weight loss in overweight and obese adults with type 2 diabetes and to examine whether changes in adipose tissue (AT) depots were associated with changes in metabolic biomarkers.

RESEARCH DESIGN AND METHODS

Participants were 54 females and 38 males (age 57.8 ± 6.7 years [mean ± SD]; BMI 31.7 ± 3.5 kg/m(2)) enrolled in the Look AHEAD (Action for Health in Diabetes) trial randomized to ILI or diabetes support and education (DSE) from whom baseline and 1-year MRI measures of total AT (TAT) and regional (arm, trunk, leg) AT, including subcutaneous AT (SAT), visceral AT (VAT), and intermuscular AT (IMAT), were acquired. We tested whether mean changes in ILI and DSE were equal and, within groups, whether changes were different from zero. Regression models tested whether changes in AT compartments were associated with metabolic variable changes.

RESULTS

Body weight changed -0.52 ± 3.62 kg (P = 0.31) in DSE and -7.24 ± 5.40 kg (P < 0.0001) in ILI. Mean ILI changes were different from DSE (P < 0.001 for TAT, SAT, and IMAT and P < 0.01 for VAT in females). Within ILI, SAT and VAT decreased in males and females (P < 0.0001), but IMAT was unchanged (0.00 ± 0.54 kg; P = 0.99). In DSE, SAT and VAT did not change, but IMAT increased by 0.46 ± 0.55 kg (P < 0.001). Controlling for weight loss, reduction of specific AT depots was associated with improvement in metabolic biomarkers.

CONCLUSIONS

Weight loss of 7-10% from an ILI over 1 year reduced SAT and VAT and prevented an increase in IMAT. Reductions in AT depots were associated with improvements in biomarkers.

Authors+Show Affiliations

New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, New York, NY Institute of Human Nutrition and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY dg108@columbia.edu.New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, New York, NY Institute of Human Nutrition and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY.Obesity/Nutrition Research Center, University of Pittsburgh, Pittsburgh, PA Diabetes and Endocrinology, Merck Research Laboratories, Rahway, NJ.New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, New York, NY.Department of Radiology, St. Luke's-Roosevelt Hospital, New York, NY.New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, New York, NY.New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, New York, NY.Obesity/Nutrition Research Center, University of Pittsburgh, Pittsburgh, PA.The Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25336745

Citation

Gallagher, Dympna, et al. "Changes in Adipose Tissue Depots and Metabolic Markers Following a 1-year Diet and Exercise Intervention in Overweight and Obese Patients With Type 2 Diabetes." Diabetes Care, vol. 37, no. 12, 2014, pp. 3325-32.
Gallagher D, Heshka S, Kelley DE, et al. Changes in adipose tissue depots and metabolic markers following a 1-year diet and exercise intervention in overweight and obese patients with type 2 diabetes. Diabetes Care. 2014;37(12):3325-32.
Gallagher, D., Heshka, S., Kelley, D. E., Thornton, J., Boxt, L., Pi-Sunyer, F. X., Patricio, J., Mancino, J., & Clark, J. M. (2014). Changes in adipose tissue depots and metabolic markers following a 1-year diet and exercise intervention in overweight and obese patients with type 2 diabetes. Diabetes Care, 37(12), 3325-32. https://doi.org/10.2337/dc14-1585
Gallagher D, et al. Changes in Adipose Tissue Depots and Metabolic Markers Following a 1-year Diet and Exercise Intervention in Overweight and Obese Patients With Type 2 Diabetes. Diabetes Care. 2014;37(12):3325-32. PubMed PMID: 25336745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in adipose tissue depots and metabolic markers following a 1-year diet and exercise intervention in overweight and obese patients with type 2 diabetes. AU - Gallagher,Dympna, AU - Heshka,Stanley, AU - Kelley,David E, AU - Thornton,John, AU - Boxt,Lawrence, AU - Pi-Sunyer,F Xavier, AU - Patricio,Jennifer, AU - Mancino,Juliet, AU - Clark,Jeanne M, AU - ,, Y1 - 2014/10/21/ PY - 2014/10/23/entrez PY - 2014/10/23/pubmed PY - 2015/6/17/medline SP - 3325 EP - 32 JF - Diabetes care JO - Diabetes Care VL - 37 IS - 12 N2 - OBJECTIVE: We aim to characterize the effects on total body fat and distribution of a 1-year intensive lifestyle intervention (ILI) for weight loss in overweight and obese adults with type 2 diabetes and to examine whether changes in adipose tissue (AT) depots were associated with changes in metabolic biomarkers. RESEARCH DESIGN AND METHODS: Participants were 54 females and 38 males (age 57.8 ± 6.7 years [mean ± SD]; BMI 31.7 ± 3.5 kg/m(2)) enrolled in the Look AHEAD (Action for Health in Diabetes) trial randomized to ILI or diabetes support and education (DSE) from whom baseline and 1-year MRI measures of total AT (TAT) and regional (arm, trunk, leg) AT, including subcutaneous AT (SAT), visceral AT (VAT), and intermuscular AT (IMAT), were acquired. We tested whether mean changes in ILI and DSE were equal and, within groups, whether changes were different from zero. Regression models tested whether changes in AT compartments were associated with metabolic variable changes. RESULTS: Body weight changed -0.52 ± 3.62 kg (P = 0.31) in DSE and -7.24 ± 5.40 kg (P < 0.0001) in ILI. Mean ILI changes were different from DSE (P < 0.001 for TAT, SAT, and IMAT and P < 0.01 for VAT in females). Within ILI, SAT and VAT decreased in males and females (P < 0.0001), but IMAT was unchanged (0.00 ± 0.54 kg; P = 0.99). In DSE, SAT and VAT did not change, but IMAT increased by 0.46 ± 0.55 kg (P < 0.001). Controlling for weight loss, reduction of specific AT depots was associated with improvement in metabolic biomarkers. CONCLUSIONS: Weight loss of 7-10% from an ILI over 1 year reduced SAT and VAT and prevented an increase in IMAT. Reductions in AT depots were associated with improvements in biomarkers. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/25336745/Changes_in_adipose_tissue_depots_and_metabolic_markers_following_a_1_year_diet_and_exercise_intervention_in_overweight_and_obese_patients_with_type_2_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=25336745 DB - PRIME DP - Unbound Medicine ER -