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Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Vasa. 2014 Nov; 43(6):404-14.VASA

Abstract

The Renin-Angiotensin system plays an important role in the regulation of systemic blood pressure as well as in fluid and electrolyte balance. It is divided into two described axes, the ACE - Ang II - AT1 receptor, with Ang II as the main mediator, and the ACE2 - Ang-(1-7) - Mas receptor, with Ang-(1-7) responsible for the main effects. The main vascular effect induced by Ang II is contraction, while Ang-(1-7) includes relaxation in several vascular beds. Ang II also activates several cytokines that are important in the genesis of vascular inflammation and hypertrophy. In this context, Ang-(1-7) seems to have a protective role. Both AT1 and Mas receptors modulate, in different ways, the generation of, which are involved in the control of vascular tone and the genesis of vascular dysfunction triggered by several diseases, including diabetes mellitus, arterial hypertension and atherosclerosis. Thereby, this review presents an overview of the modulation played by the whole Renin-Angiotensin system on the reactive oxygen species-mediated control of vascular tone and the oxidative stress-elicited vascular dysfunction.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.Department of Medicine, University of Ribeirão Preto, São Paulo, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25339158

Citation

Pernomian, Laena, et al. "Counter-regulatory Effects Played By the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas Axes On the Reactive Oxygen Species-mediated Control of Vascular Function: Perspectives to Pharmacological Approaches in Controlling Vascular Complications." VASA. Zeitschrift Fur Gefasskrankheiten, vol. 43, no. 6, 2014, pp. 404-14.
Pernomian L, Pernomian L, Baraldi Araújo Restini C. Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications. Vasa. 2014;43(6):404-14.
Pernomian, L., Pernomian, L., & Baraldi Araújo Restini, C. (2014). Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications. VASA. Zeitschrift Fur Gefasskrankheiten, 43(6), 404-14. https://doi.org/10.1024/0301-1526/a000387
Pernomian L, Pernomian L, Baraldi Araújo Restini C. Counter-regulatory Effects Played By the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas Axes On the Reactive Oxygen Species-mediated Control of Vascular Function: Perspectives to Pharmacological Approaches in Controlling Vascular Complications. Vasa. 2014;43(6):404-14. PubMed PMID: 25339158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications. AU - Pernomian,Laena, AU - Pernomian,Larissa, AU - Baraldi Araújo Restini,Carolina, PY - 2014/10/24/entrez PY - 2014/10/24/pubmed PY - 2015/2/7/medline KW - AT1 receptors KW - Angiotensin II KW - Mas receptors KW - angiotensin-(1-7) KW - reactive oxygen species KW - vascular dysfunction SP - 404 EP - 14 JF - VASA. Zeitschrift fur Gefasskrankheiten JO - Vasa VL - 43 IS - 6 N2 - The Renin-Angiotensin system plays an important role in the regulation of systemic blood pressure as well as in fluid and electrolyte balance. It is divided into two described axes, the ACE - Ang II - AT1 receptor, with Ang II as the main mediator, and the ACE2 - Ang-(1-7) - Mas receptor, with Ang-(1-7) responsible for the main effects. The main vascular effect induced by Ang II is contraction, while Ang-(1-7) includes relaxation in several vascular beds. Ang II also activates several cytokines that are important in the genesis of vascular inflammation and hypertrophy. In this context, Ang-(1-7) seems to have a protective role. Both AT1 and Mas receptors modulate, in different ways, the generation of, which are involved in the control of vascular tone and the genesis of vascular dysfunction triggered by several diseases, including diabetes mellitus, arterial hypertension and atherosclerosis. Thereby, this review presents an overview of the modulation played by the whole Renin-Angiotensin system on the reactive oxygen species-mediated control of vascular tone and the oxidative stress-elicited vascular dysfunction. SN - 0301-1526 UR - https://www.unboundmedicine.com/medline/citation/25339158/Counter_regulatory_effects_played_by_the_ACE___Ang_II___AT1_and_ACE2___Ang__1_7____Mas_axes_on_the_reactive_oxygen_species_mediated_control_of_vascular_function:_perspectives_to_pharmacological_approaches_in_controlling_vascular_complications_ L2 - https://econtent.hogrefe.com/doi/10.1024/0301-1526/a000387?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -