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Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average-risk individuals.
Aliment Pharmacol Ther. 2015 Jan; 41(1):108-15.AP

Abstract

BACKGROUND

Serrated polyps of the colorectum have distinct histological features and malignant potential.

AIM

To assess the association between the presence of serrated polyps and synchronous advanced colorectal neoplasia.

METHODS

Among 4989 asymptomatic Chinese individuals aged 50-70 years who underwent screening colonoscopy, 281 cases with advanced neoplasia (adenoma ≥1 cm, with tubulovillous/villous histology, with high-grade dysplasia, or invasive adenocarcinoma) were compared with 4708 controls without advanced neoplasia for age, sex, smoking history, body mass index, family history of colorectal cancer and the presence of serrated polyps. Independent predictors of advanced neoplasia were determined by multivariate logistic regression analysis.

RESULTS

The prevalence of advanced neoplasia and serrated polyps (excluding small distal hyperplastic polyps) was 5.7% and 5.6%, respectively. 3.7% and 0.4% subjects had proximal and large (≥10 mm) serrated polyps, respectively. Independent predictors of synchronous advanced colorectal neoplasia were the presence of sessile serrated adenomas (OR: 4.52; 95% CI: 2.40-8.49), proximal serrated polyps (OR: 2.23, 95% CI: 1.38-3.60), large serrated polyps (OR: 59.25; 95% CI: 18.85-186.21), hyperplastic polyps (OR: 1.66; 95% CI: 1.03-2.67), three or more serrated polyps (OR: 4.86; 95% CI: 1.24-19.15) and one or more non-advanced tubular adenomas (OR: 3.58, 95% CI: 2.59-4.96).

CONCLUSION

Detection of proximal, sessile and/or large serrated polyps at screening colonoscopy is independently associated with an increased risk for synchronous advanced neoplasia.

Authors+Show Affiliations

Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, State Key Laboratory of Digestive Diseases, Chinese University of Hong Kong, Shatin, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25339583

Citation

Ng, S C., et al. "Association Between Serrated Polyps and the Risk of Synchronous Advanced Colorectal Neoplasia in Average-risk Individuals." Alimentary Pharmacology & Therapeutics, vol. 41, no. 1, 2015, pp. 108-15.
Ng SC, Ching JY, Chan VC, et al. Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average-risk individuals. Aliment Pharmacol Ther. 2015;41(1):108-15.
Ng, S. C., Ching, J. Y., Chan, V. C., Wong, M. C., Tang, R., Wong, S., Luk, A. K., Lam, T. Y., Gao, Q., Chan, A. W., Wu, J. C., Chan, F. K., Lau, J. Y., & Sung, J. J. (2015). Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average-risk individuals. Alimentary Pharmacology & Therapeutics, 41(1), 108-15. https://doi.org/10.1111/apt.13003
Ng SC, et al. Association Between Serrated Polyps and the Risk of Synchronous Advanced Colorectal Neoplasia in Average-risk Individuals. Aliment Pharmacol Ther. 2015;41(1):108-15. PubMed PMID: 25339583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average-risk individuals. AU - Ng,S C, AU - Ching,J Y L, AU - Chan,V C W, AU - Wong,M C S, AU - Tang,R, AU - Wong,S, AU - Luk,A K C, AU - Lam,T Y T, AU - Gao,Q, AU - Chan,A W H, AU - Wu,J C Y, AU - Chan,F K L, AU - Lau,J Y W, AU - Sung,J J Y, Y1 - 2014/10/22/ PY - 2014/08/14/received PY - 2014/09/12/revised PY - 2014/09/29/revised PY - 2014/10/06/accepted PY - 2014/10/24/entrez PY - 2014/10/24/pubmed PY - 2015/6/2/medline SP - 108 EP - 15 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 41 IS - 1 N2 - BACKGROUND: Serrated polyps of the colorectum have distinct histological features and malignant potential. AIM: To assess the association between the presence of serrated polyps and synchronous advanced colorectal neoplasia. METHODS: Among 4989 asymptomatic Chinese individuals aged 50-70 years who underwent screening colonoscopy, 281 cases with advanced neoplasia (adenoma ≥1 cm, with tubulovillous/villous histology, with high-grade dysplasia, or invasive adenocarcinoma) were compared with 4708 controls without advanced neoplasia for age, sex, smoking history, body mass index, family history of colorectal cancer and the presence of serrated polyps. Independent predictors of advanced neoplasia were determined by multivariate logistic regression analysis. RESULTS: The prevalence of advanced neoplasia and serrated polyps (excluding small distal hyperplastic polyps) was 5.7% and 5.6%, respectively. 3.7% and 0.4% subjects had proximal and large (≥10 mm) serrated polyps, respectively. Independent predictors of synchronous advanced colorectal neoplasia were the presence of sessile serrated adenomas (OR: 4.52; 95% CI: 2.40-8.49), proximal serrated polyps (OR: 2.23, 95% CI: 1.38-3.60), large serrated polyps (OR: 59.25; 95% CI: 18.85-186.21), hyperplastic polyps (OR: 1.66; 95% CI: 1.03-2.67), three or more serrated polyps (OR: 4.86; 95% CI: 1.24-19.15) and one or more non-advanced tubular adenomas (OR: 3.58, 95% CI: 2.59-4.96). CONCLUSION: Detection of proximal, sessile and/or large serrated polyps at screening colonoscopy is independently associated with an increased risk for synchronous advanced neoplasia. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/25339583/Association_between_serrated_polyps_and_the_risk_of_synchronous_advanced_colorectal_neoplasia_in_average_risk_individuals_ L2 - https://doi.org/10.1111/apt.13003 DB - PRIME DP - Unbound Medicine ER -