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Influences of the inner retinal sublayers and analytical areas in macular scans by spectral-domain OCT on the diagnostic ability of early glaucoma.
Invest Ophthalmol Vis Sci. 2014 Oct 23; 55(11):7479-85.IO

Abstract

PURPOSE

We investigated the influences of the inner retinal sublayers and analytical areas in macular scans by spectral-domain optical coherence tomography (OCT) on the diagnostic ability of early glaucoma.

METHODS

A total of 64 early (including 24 preperimetric) glaucomatous and 40 normal eyes underwent macular and peripapillary retinal nerve fiber layer (pRNFL) scans (3D-OCT-2000). The area under the receiver operating characteristics (AUC) for glaucoma diagnosis was determined from the average thickness of the total 100 grids (6 × 6 mm), central 44 grids (3.6 × 4.8 mm), and peripheral 56 grids (outside of the 44 grids), and for each macular sublayer: macular RNFL (mRNFL), ganglion cell layer plus inner plexiform layer (GCL/IPL), and mRNFL plus GCL/IPL (ganglion cell complex [GCC]). Correlation of OCT parameters with visual field parameters was evaluated by Spearman's rank correlation coefficients (rs).

RESULTS

The GCC-related parameters had a significantly larger AUC (0.82-0.97) than GCL/IPL (0.81-0.91), mRNFL-related parameters (0.72-0.94), or average pRNFL (0.88) in more than half of all comparisons. The central 44 grids had a significantly lower AUC than other analytical areas in GCC and mRNFL thickness. Conversely, the peripheral 56 grids had a significantly lower AUC than the 100 grids in GCL/IPL inferior thickness. Inferior thickness of GCC (rs, 0.45-0.49) and mRNFL (rs, 0.43-0.51) showed comparably high correlations with central visual field parameters to average pRNFL thickness (rs, 0.41, 0.47) even in the central 44 grids.

CONCLUSIONS

The diagnostic ability of macular OCT parameters for early glaucoma differed by inner retinal sublayers and also by the analytical areas studied.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Department of Ophthalmology, Koseiren Takaoka Hospital, Takaoka, Japan.Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25342613

Citation

Nakatani, Yusuke, et al. "Influences of the Inner Retinal Sublayers and Analytical Areas in Macular Scans By Spectral-domain OCT On the Diagnostic Ability of Early Glaucoma." Investigative Ophthalmology & Visual Science, vol. 55, no. 11, 2014, pp. 7479-85.
Nakatani Y, Higashide T, Ohkubo S, et al. Influences of the inner retinal sublayers and analytical areas in macular scans by spectral-domain OCT on the diagnostic ability of early glaucoma. Invest Ophthalmol Vis Sci. 2014;55(11):7479-85.
Nakatani, Y., Higashide, T., Ohkubo, S., & Sugiyama, K. (2014). Influences of the inner retinal sublayers and analytical areas in macular scans by spectral-domain OCT on the diagnostic ability of early glaucoma. Investigative Ophthalmology & Visual Science, 55(11), 7479-85. https://doi.org/10.1167/iovs.14-15530
Nakatani Y, et al. Influences of the Inner Retinal Sublayers and Analytical Areas in Macular Scans By Spectral-domain OCT On the Diagnostic Ability of Early Glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 23;55(11):7479-85. PubMed PMID: 25342613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influences of the inner retinal sublayers and analytical areas in macular scans by spectral-domain OCT on the diagnostic ability of early glaucoma. AU - Nakatani,Yusuke, AU - Higashide,Tomomi, AU - Ohkubo,Shinji, AU - Sugiyama,Kazuhisa, Y1 - 2014/10/23/ PY - 2014/10/25/entrez PY - 2014/10/25/pubmed PY - 2015/1/28/medline KW - diagnostic ability KW - differences by sublayers and analytical area KW - inner macular parameter KW - spectral-domain optical coherence tomography SP - 7479 EP - 85 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 55 IS - 11 N2 - PURPOSE: We investigated the influences of the inner retinal sublayers and analytical areas in macular scans by spectral-domain optical coherence tomography (OCT) on the diagnostic ability of early glaucoma. METHODS: A total of 64 early (including 24 preperimetric) glaucomatous and 40 normal eyes underwent macular and peripapillary retinal nerve fiber layer (pRNFL) scans (3D-OCT-2000). The area under the receiver operating characteristics (AUC) for glaucoma diagnosis was determined from the average thickness of the total 100 grids (6 × 6 mm), central 44 grids (3.6 × 4.8 mm), and peripheral 56 grids (outside of the 44 grids), and for each macular sublayer: macular RNFL (mRNFL), ganglion cell layer plus inner plexiform layer (GCL/IPL), and mRNFL plus GCL/IPL (ganglion cell complex [GCC]). Correlation of OCT parameters with visual field parameters was evaluated by Spearman's rank correlation coefficients (rs). RESULTS: The GCC-related parameters had a significantly larger AUC (0.82-0.97) than GCL/IPL (0.81-0.91), mRNFL-related parameters (0.72-0.94), or average pRNFL (0.88) in more than half of all comparisons. The central 44 grids had a significantly lower AUC than other analytical areas in GCC and mRNFL thickness. Conversely, the peripheral 56 grids had a significantly lower AUC than the 100 grids in GCL/IPL inferior thickness. Inferior thickness of GCC (rs, 0.45-0.49) and mRNFL (rs, 0.43-0.51) showed comparably high correlations with central visual field parameters to average pRNFL thickness (rs, 0.41, 0.47) even in the central 44 grids. CONCLUSIONS: The diagnostic ability of macular OCT parameters for early glaucoma differed by inner retinal sublayers and also by the analytical areas studied. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/25342613/Influences_of_the_inner_retinal_sublayers_and_analytical_areas_in_macular_scans_by_spectral_domain_OCT_on_the_diagnostic_ability_of_early_glaucoma_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-15530 DB - PRIME DP - Unbound Medicine ER -