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Artificially and sugar-sweetened carbonated beverage consumption is not associated with risk of lymphoid neoplasms in older men and women.
J Nutr. 2014 Dec; 144(12):2041-9.JN

Abstract

BACKGROUND

Concern about the carcinogenic potential of aspartame was raised after an increase in lymphomas and leukemia was reported in an animal study at doses similar to human exposure. Two prospective cohort studies published after the report found inconsistent results for estimated aspartame intake, artificially sweetened beverage consumption, and risk of lymphoid neoplasms.

OBJECTIVE

The objective of this study was to examine associations of artificially and sugar-sweetened carbonated beverage consumption (for comparison) and aspartame intake with risk of non-Hodgkin lymphoma (NHL) overall and by major histologic subtype in the Cancer Prevention Study-II Nutrition Cohort.

METHODS

Among 100,442 adult men and women who provided information on diet and lifestyle factors in 1999, 1196 NHL cases were verified during a 10-y follow-up period. Cox proportional hazards regression was used to estimate multivariable-adjusted RRs and 95% CIs.

RESULTS

In women and men combined, there were no associations of consumption of ≥1 (355 mL) servings/d of artificially (RR: 0.92; 95% CI: 0.73, 1.17; P-trend: 0.14) or sugar- (RR: 1.10; 95% CI: 0.77, 1.58; P-trend: 0.62) sweetened carbonated beverages with NHL risk, compared to no consumption (P-heterogeneity by gender: 0.11-1.00). Similarly, aspartame intake was not associated with NHL risk (RR: 1.02; 95% CI: 0.84, 1.24; P-trend: 0.69, top vs. bottom quintile). Associations with NHL subtype (multiple myeloma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and follicular and other B-cell lymphoma) were generally null.

CONCLUSION

These findings do not support associations of daily consumption of artificially or sugar-sweetened carbonated beverages, or aspartame, with NHL risk.

Authors+Show Affiliations

Epidemiology Research Program, American Cancer Society, Atlanta, GA marji.mccullough@cancer.org.Epidemiology Research Program, American Cancer Society, Atlanta, GA.Epidemiology Research Program, American Cancer Society, Atlanta, GA.Epidemiology Research Program, American Cancer Society, Atlanta, GA.Epidemiology Research Program, American Cancer Society, Atlanta, GA.Epidemiology Research Program, American Cancer Society, Atlanta, GA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25342696

Citation

McCullough, Marjorie L., et al. "Artificially and Sugar-sweetened Carbonated Beverage Consumption Is Not Associated With Risk of Lymphoid Neoplasms in Older Men and Women." The Journal of Nutrition, vol. 144, no. 12, 2014, pp. 2041-9.
McCullough ML, Teras LR, Shah R, et al. Artificially and sugar-sweetened carbonated beverage consumption is not associated with risk of lymphoid neoplasms in older men and women. J Nutr. 2014;144(12):2041-9.
McCullough, M. L., Teras, L. R., Shah, R., Diver, W. R., Gaudet, M. M., & Gapstur, S. M. (2014). Artificially and sugar-sweetened carbonated beverage consumption is not associated with risk of lymphoid neoplasms in older men and women. The Journal of Nutrition, 144(12), 2041-9. https://doi.org/10.3945/jn.114.197475
McCullough ML, et al. Artificially and Sugar-sweetened Carbonated Beverage Consumption Is Not Associated With Risk of Lymphoid Neoplasms in Older Men and Women. J Nutr. 2014;144(12):2041-9. PubMed PMID: 25342696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Artificially and sugar-sweetened carbonated beverage consumption is not associated with risk of lymphoid neoplasms in older men and women. AU - McCullough,Marjorie L, AU - Teras,Lauren R, AU - Shah,Roma, AU - Diver,W Ryan, AU - Gaudet,Mia M, AU - Gapstur,Susan M, Y1 - 2014/10/23/ PY - 2014/10/25/entrez PY - 2014/10/25/pubmed PY - 2015/2/18/medline KW - artificially sweetened carbonated beverages KW - aspartame KW - lymphoid neoplasms KW - prospective cohort study KW - sugar-sweetened carbonated beverages SP - 2041 EP - 9 JF - The Journal of nutrition JO - J Nutr VL - 144 IS - 12 N2 - BACKGROUND: Concern about the carcinogenic potential of aspartame was raised after an increase in lymphomas and leukemia was reported in an animal study at doses similar to human exposure. Two prospective cohort studies published after the report found inconsistent results for estimated aspartame intake, artificially sweetened beverage consumption, and risk of lymphoid neoplasms. OBJECTIVE: The objective of this study was to examine associations of artificially and sugar-sweetened carbonated beverage consumption (for comparison) and aspartame intake with risk of non-Hodgkin lymphoma (NHL) overall and by major histologic subtype in the Cancer Prevention Study-II Nutrition Cohort. METHODS: Among 100,442 adult men and women who provided information on diet and lifestyle factors in 1999, 1196 NHL cases were verified during a 10-y follow-up period. Cox proportional hazards regression was used to estimate multivariable-adjusted RRs and 95% CIs. RESULTS: In women and men combined, there were no associations of consumption of ≥1 (355 mL) servings/d of artificially (RR: 0.92; 95% CI: 0.73, 1.17; P-trend: 0.14) or sugar- (RR: 1.10; 95% CI: 0.77, 1.58; P-trend: 0.62) sweetened carbonated beverages with NHL risk, compared to no consumption (P-heterogeneity by gender: 0.11-1.00). Similarly, aspartame intake was not associated with NHL risk (RR: 1.02; 95% CI: 0.84, 1.24; P-trend: 0.69, top vs. bottom quintile). Associations with NHL subtype (multiple myeloma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and follicular and other B-cell lymphoma) were generally null. CONCLUSION: These findings do not support associations of daily consumption of artificially or sugar-sweetened carbonated beverages, or aspartame, with NHL risk. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/25342696/Artificially_and_sugar_sweetened_carbonated_beverage_consumption_is_not_associated_with_risk_of_lymphoid_neoplasms_in_older_men_and_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.114.197475 DB - PRIME DP - Unbound Medicine ER -