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Treatment of aspirin exacerbated respiratory disease with a low salicylate diet: a pilot crossover study.
Otolaryngol Head Neck Surg. 2015 Jan; 152(1):42-7.OH

Abstract

OBJECTIVE

Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization.

STUDY DESIGN

A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS).

SETTING

The study was conducted in a tertiary otolaryngology clinic.

SUBJECTS

Patients with AERD were enrolled in the study.

METHODS

Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks.

RESULTS

Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005).

CONCLUSION

Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Sommer DD
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Canada.
Hoffbauer S
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Canada.
Au M
Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada.
Sowerby LJ
Department of Otolaryngology-Head and Neck Surgery, Western University, London, Canada.
Gupta MK
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Canada.
Nayan S
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Canada smriti.nayan@medportal.ca.

MeSH

AdultAgedAspirinAsthmaCross-Over StudiesDesensitization, ImmunologicDrug HypersensitivityFemaleHumansMaleMiddle AgedNasal PolypsPilot ProjectsProspective StudiesRespiratory Tract DiseasesRhinitisSalicylatesSingle-Blind MethodSinusitis

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25344589

Clinical Trial Links

Dupilumab for Aspirin-exacerbated Respiratory Disease

Citation

Sommer, Doron D., et al. "Treatment of Aspirin Exacerbated Respiratory Disease With a Low Salicylate Diet: a Pilot Crossover Study." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 152, no. 1, 2015, pp. 42-7.
Sommer DD, Hoffbauer S, Au M, et al. Treatment of aspirin exacerbated respiratory disease with a low salicylate diet: a pilot crossover study. Otolaryngol Head Neck Surg. 2015;152(1):42-7.
Sommer, D. D., Hoffbauer, S., Au, M., Sowerby, L. J., Gupta, M. K., & Nayan, S. (2015). Treatment of aspirin exacerbated respiratory disease with a low salicylate diet: a pilot crossover study. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 152(1), 42-7. https://doi.org/10.1177/0194599814555836
Sommer DD, et al. Treatment of Aspirin Exacerbated Respiratory Disease With a Low Salicylate Diet: a Pilot Crossover Study. Otolaryngol Head Neck Surg. 2015;152(1):42-7. PubMed PMID: 25344589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of aspirin exacerbated respiratory disease with a low salicylate diet: a pilot crossover study. AU - Sommer,Doron D, AU - Hoffbauer,Stephanie, AU - Au,Michael, AU - Sowerby,Leigh J, AU - Gupta,Michael K, AU - Nayan,Smriti, Y1 - 2014/10/24/ PY - 2014/10/26/entrez PY - 2014/10/26/pubmed PY - 2015/6/16/medline KW - aspirin exacerbated respiratory disease KW - asthma KW - low salicylate diet KW - nasal polyps KW - salicylates KW - sinusitis SP - 42 EP - 7 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 152 IS - 1 N2 - OBJECTIVE: Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization. STUDY DESIGN: A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS). SETTING: The study was conducted in a tertiary otolaryngology clinic. SUBJECTS: Patients with AERD were enrolled in the study. METHODS: Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks. RESULTS: Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005). CONCLUSION: Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/25344589/Treatment_of_aspirin_exacerbated_respiratory_disease_with_a_low_salicylate_diet:_a_pilot_crossover_study_ DB - PRIME DP - Unbound Medicine ER -