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Construction of axial chirality by rhodium-catalyzed asymmetric dehydrogenative Heck coupling of biaryl compounds with alkenes.
Angew Chem Int Ed Engl. 2014 Nov 24; 53(48):13244-7.AC

Abstract

Enantioselective construction of axially chiral biaryls by direct C-H bond functionalization reactions has been realized. Novel axially chiral biaryls were synthesized by the direct C-H bond olefination of biaryl compounds, using a chiral [Cp*Rh(III)] catalyst, in good to excellent yields and enantioselectivities. The obtained axially chiral biaryls were found as suitable ligands for rhodium-catalyzed asymmetric conjugate additions.

Authors+Show Affiliations

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25346171

Citation

Zheng, Jun, and Shu-Li You. "Construction of Axial Chirality By Rhodium-catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds With Alkenes." Angewandte Chemie (International Ed. in English), vol. 53, no. 48, 2014, pp. 13244-7.
Zheng J, You SL. Construction of axial chirality by rhodium-catalyzed asymmetric dehydrogenative Heck coupling of biaryl compounds with alkenes. Angew Chem Int Ed Engl. 2014;53(48):13244-7.
Zheng, J., & You, S. L. (2014). Construction of axial chirality by rhodium-catalyzed asymmetric dehydrogenative Heck coupling of biaryl compounds with alkenes. Angewandte Chemie (International Ed. in English), 53(48), 13244-7. https://doi.org/10.1002/anie.201408805
Zheng J, You SL. Construction of Axial Chirality By Rhodium-catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds With Alkenes. Angew Chem Int Ed Engl. 2014 Nov 24;53(48):13244-7. PubMed PMID: 25346171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Construction of axial chirality by rhodium-catalyzed asymmetric dehydrogenative Heck coupling of biaryl compounds with alkenes. AU - Zheng,Jun, AU - You,Shu-Li, Y1 - 2014/10/24/ PY - 2014/09/04/received PY - 2014/10/04/revised PY - 2014/10/28/entrez PY - 2014/10/28/pubmed PY - 2015/9/17/medline KW - CH activation KW - asymmetric catalysis KW - biaryls KW - chirality KW - rhodium SP - 13244 EP - 7 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 53 IS - 48 N2 - Enantioselective construction of axially chiral biaryls by direct C-H bond functionalization reactions has been realized. Novel axially chiral biaryls were synthesized by the direct C-H bond olefination of biaryl compounds, using a chiral [Cp*Rh(III)] catalyst, in good to excellent yields and enantioselectivities. The obtained axially chiral biaryls were found as suitable ligands for rhodium-catalyzed asymmetric conjugate additions. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/25346171/Construction_of_axial_chirality_by_rhodium_catalyzed_asymmetric_dehydrogenative_Heck_coupling_of_biaryl_compounds_with_alkenes_ L2 - https://doi.org/10.1002/anie.201408805 DB - PRIME DP - Unbound Medicine ER -