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Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward.
Antimicrob Agents Chemother. 2015 Jan; 59(1):714-6.AA

Abstract

We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca isolates were identified in sink drains in 4 patient rooms and in the medication room. Investigations for resistance genes and genetic relatedness of patient and environmental isolates revealed that all the isolates harbored the blaKPC-2 and blaTEM-1 genes and were genetically indistinguishable. We describe here a clonal outbreak caused by KPC-2-producing K. oxytoca, and handwashing sinks were a possible reservoir.

Authors+Show Affiliations

Institute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.Institute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.Institute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.Austrian Agency for Health and Food Safety, Institute of Medical Microbiology and Hygiene, Graz, Austria.Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.Institute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.Institute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria ines.schwetz@medunigraz.at.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25348541

Citation

Leitner, Eva, et al. "Contaminated Handwashing Sinks as the Source of a Clonal Outbreak of KPC-2-producing Klebsiella Oxytoca On a Hematology Ward." Antimicrobial Agents and Chemotherapy, vol. 59, no. 1, 2015, pp. 714-6.
Leitner E, Zarfel G, Luxner J, et al. Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward. Antimicrob Agents Chemother. 2015;59(1):714-6.
Leitner, E., Zarfel, G., Luxner, J., Herzog, K., Pekard-Amenitsch, S., Hoenigl, M., Valentin, T., Feierl, G., Grisold, A. J., Högenauer, C., Sill, H., Krause, R., & Zollner-Schwetz, I. (2015). Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward. Antimicrobial Agents and Chemotherapy, 59(1), 714-6. https://doi.org/10.1128/AAC.04306-14
Leitner E, et al. Contaminated Handwashing Sinks as the Source of a Clonal Outbreak of KPC-2-producing Klebsiella Oxytoca On a Hematology Ward. Antimicrob Agents Chemother. 2015;59(1):714-6. PubMed PMID: 25348541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward. AU - Leitner,Eva, AU - Zarfel,Gernot, AU - Luxner,Josefa, AU - Herzog,Kathrin, AU - Pekard-Amenitsch,Shiva, AU - Hoenigl,Martin, AU - Valentin,Thomas, AU - Feierl,Gebhard, AU - Grisold,Andrea J, AU - Högenauer,Christoph, AU - Sill,Heinz, AU - Krause,Robert, AU - Zollner-Schwetz,Ines, Y1 - 2014/10/27/ PY - 2014/10/29/entrez PY - 2014/10/29/pubmed PY - 2015/8/25/medline SP - 714 EP - 6 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 59 IS - 1 N2 - We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca isolates were identified in sink drains in 4 patient rooms and in the medication room. Investigations for resistance genes and genetic relatedness of patient and environmental isolates revealed that all the isolates harbored the blaKPC-2 and blaTEM-1 genes and were genetically indistinguishable. We describe here a clonal outbreak caused by KPC-2-producing K. oxytoca, and handwashing sinks were a possible reservoir. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/25348541/Contaminated_handwashing_sinks_as_the_source_of_a_clonal_outbreak_of_KPC_2_producing_Klebsiella_oxytoca_on_a_hematology_ward_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=25348541 DB - PRIME DP - Unbound Medicine ER -