Tags

Type your tag names separated by a space and hit enter

In vitro antifungal activity and mechanism of essential oil from fennel (Foeniculum vulgare L.) on dermatophyte species.
J Med Microbiol. 2015 Jan; 64(Pt 1):93-103.JM

Abstract

Fennel seed essential oil (FSEO) is a plant-derived natural therapeutic against dermatophytes. In this study, the antifungal effects of FSEO were investigated from varied aspects, such as MIC and minimum fungicidal concentration, mycelia growth, spore germination and biomass. The results indicated that FSEO had potent antifungal activities on Trichophyton rubrum ATCC 40051, Trichophyton tonsurans 10-0400, Microsporum gypseum 44693-1 and Trichophyton mentagrophytes 10-0060, which is better than the commonly used antifungal agents fluconazole and amphotericin B. Flow cytometry and transmission electron microscopy experiments suggested that the antifungal mechanism of FSEO was to damage the plasma membrane and intracellular organelles. Further study revealed that it could also inhibit the mitochondrial enzyme activities, such as succinate dehydrogenase, malate dehydrogenase and ATPase. With better antifungal activity than the commonly used antifungal agents and less possibility of inducing drug resistance, FSEO could be used as a potential antidermatophytic agent.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Zeng H
Key Laboratory of Protection and Utilization of Biological Resources, College of Life Science, Tarim University, Alar, 843300, Xinjiang, PR China.
Chen X
Key Laboratory of Protection and Utilization of Biological Resources, College of Life Science, Tarim University, Alar, 843300, Xinjiang, PR China.
Liang J
Instrument Center, Institute of Microbiology, Chinese Academy of Sciences, 100000 Beijing, PR China.

MeSH

Antifungal AgentsArthrodermataceaeBiomassCell MembraneFlow CytometryFoeniculumMicrobial Sensitivity TestsMicrobial ViabilityMicroscopy, Electron, TransmissionMicrosporumMitochondriaOils, VolatileOrganellesSeedsSpores, FungalTrichophyton

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25351709

Citation

Zeng, Hong, et al. "In Vitro Antifungal Activity and Mechanism of Essential Oil From Fennel (Foeniculum Vulgare L.) On Dermatophyte Species." Journal of Medical Microbiology, vol. 64, no. Pt 1, 2015, pp. 93-103.
Zeng H, Chen X, Liang J. In vitro antifungal activity and mechanism of essential oil from fennel (Foeniculum vulgare L.) on dermatophyte species. J Med Microbiol. 2015;64(Pt 1):93-103.
Zeng, H., Chen, X., & Liang, J. (2015). In vitro antifungal activity and mechanism of essential oil from fennel (Foeniculum vulgare L.) on dermatophyte species. Journal of Medical Microbiology, 64(Pt 1), 93-103. https://doi.org/10.1099/jmm.0.077768-0
Zeng H, Chen X, Liang J. In Vitro Antifungal Activity and Mechanism of Essential Oil From Fennel (Foeniculum Vulgare L.) On Dermatophyte Species. J Med Microbiol. 2015;64(Pt 1):93-103. PubMed PMID: 25351709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antifungal activity and mechanism of essential oil from fennel (Foeniculum vulgare L.) on dermatophyte species. AU - Zeng,Hong, AU - Chen,Xinping, AU - Liang,Jingnan, Y1 - 2014/10/28/ PY - 2014/10/30/entrez PY - 2014/10/30/pubmed PY - 2015/2/25/medline SP - 93 EP - 103 JF - Journal of medical microbiology JO - J Med Microbiol VL - 64 IS - Pt 1 N2 - Fennel seed essential oil (FSEO) is a plant-derived natural therapeutic against dermatophytes. In this study, the antifungal effects of FSEO were investigated from varied aspects, such as MIC and minimum fungicidal concentration, mycelia growth, spore germination and biomass. The results indicated that FSEO had potent antifungal activities on Trichophyton rubrum ATCC 40051, Trichophyton tonsurans 10-0400, Microsporum gypseum 44693-1 and Trichophyton mentagrophytes 10-0060, which is better than the commonly used antifungal agents fluconazole and amphotericin B. Flow cytometry and transmission electron microscopy experiments suggested that the antifungal mechanism of FSEO was to damage the plasma membrane and intracellular organelles. Further study revealed that it could also inhibit the mitochondrial enzyme activities, such as succinate dehydrogenase, malate dehydrogenase and ATPase. With better antifungal activity than the commonly used antifungal agents and less possibility of inducing drug resistance, FSEO could be used as a potential antidermatophytic agent. SN - 1473-5644 UR - https://www.unboundmedicine.com/medline/citation/25351709/In_vitro_antifungal_activity_and_mechanism_of_essential_oil_from_fennel__Foeniculum_vulgare_L___on_dermatophyte_species_ DB - PRIME DP - Unbound Medicine ER -