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Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration.
Hum Reprod 2015; 30(1):133-48HR

Abstract

STUDY QUESTION

Do any proteomic biomarkers previously identified for pre-eclampsia (PE) overlap with those identified in women with polycystic ovary syndrome (PCOS).

SUMMARY ANSWER

Five previously identified proteomic biomarkers were found to be common in women with PE and PCOS when compared with controls.

WHAT IS KNOWN ALREADY

Various studies have indicated an association between PCOS and PE; however, the pathophysiological mechanisms supporting this association are not known.

STUDY DESIGN, SIZE, DURATION

A systematic review and update of our PCOS proteomic biomarker database was performed, along with a parallel review of PE biomarkers. The study included papers from 1980 to December 2013.

PARTICIPANTS/MATERIALS, SETTING, METHODS

In all the studies analysed, there were a total of 1423 patients and controls. The number of proteomic biomarkers that were catalogued for PE was 192.

MAIN RESULTS AND THE ROLE OF CHANCE

Five proteomic biomarkers were shown to be differentially expressed in women with PE and PCOS when compared with controls: transferrin, fibrinogen α, β and γ chain variants, kininogen-1, annexin 2 and peroxiredoxin 2. In PE, the biomarkers were identified in serum, plasma and placenta and in PCOS, the biomarkers were identified in serum, follicular fluid, and ovarian and omental biopsies.

LIMITATIONS, REASONS FOR CAUTION

The techniques employed to detect proteomics have limited ability in identifying proteins that are of low abundance, some of which may have a diagnostic potential. The sample sizes and number of biomarkers identified from these studies do not exclude the risk of false positives, a limitation of all biomarker studies. The biomarkers common to PE and PCOS were identified from proteomic analyses of different tissues.

WIDER IMPLICATIONS OF THE FINDINGS

This data amalgamation of the proteomic studies in PE and in PCOS, for the first time, discovered a panel of five biomarkers for PE which are common to women with PCOS, including transferrin, fibrinogen α, β and γ chain variants, kininogen-1, annexin 2 and peroxiredoxin 2. If validated, these biomarkers could provide a useful framework for the knowledge infrastructure in this area. To accomplish this goal, a well co-ordinated multidisciplinary collaboration of clinicians, basic scientists and mathematicians is vital.

STUDY FUNDING/COMPETING INTERESTS

No financial support was obtained for this project. There are no conflicts of interest.

Authors+Show Affiliations

Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre, D Floor, East Block, Nottingham, UK gulafshanahafeez@hotmail.com.Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre, D Floor, East Block, Nottingham, UK.Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre, D Floor, East Block, Nottingham, UK.School of Life Sciences, University of Nottingham, Nottingham, UK.Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre, D Floor, East Block, Nottingham, UK.

Pub Type(s)

Comparative Study
Journal Article
Review
Systematic Review

Language

eng

PubMed ID

25351721

Citation

Khan, Gulafshana Hafeez, et al. "Overlap of Proteomics Biomarkers Between Women With Pre-eclampsia and PCOS: a Systematic Review and Biomarker Database Integration." Human Reproduction (Oxford, England), vol. 30, no. 1, 2015, pp. 133-48.
Khan GH, Galazis N, Docheva N, et al. Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration. Hum Reprod. 2015;30(1):133-48.
Khan, G. H., Galazis, N., Docheva, N., Layfield, R., & Atiomo, W. (2015). Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration. Human Reproduction (Oxford, England), 30(1), pp. 133-48. doi:10.1093/humrep/deu268.
Khan GH, et al. Overlap of Proteomics Biomarkers Between Women With Pre-eclampsia and PCOS: a Systematic Review and Biomarker Database Integration. Hum Reprod. 2015;30(1):133-48. PubMed PMID: 25351721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration. AU - Khan,Gulafshana Hafeez, AU - Galazis,Nicolas, AU - Docheva,Nikolina, AU - Layfield,Robert, AU - Atiomo,William, Y1 - 2014/10/28/ PY - 2014/10/30/entrez PY - 2014/10/30/pubmed PY - 2016/4/5/medline KW - biomarker KW - overlap KW - polycystic ovarian syndrome KW - pre-eclampsia KW - proteomic SP - 133 EP - 48 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 30 IS - 1 N2 - STUDY QUESTION: Do any proteomic biomarkers previously identified for pre-eclampsia (PE) overlap with those identified in women with polycystic ovary syndrome (PCOS). SUMMARY ANSWER: Five previously identified proteomic biomarkers were found to be common in women with PE and PCOS when compared with controls. WHAT IS KNOWN ALREADY: Various studies have indicated an association between PCOS and PE; however, the pathophysiological mechanisms supporting this association are not known. STUDY DESIGN, SIZE, DURATION: A systematic review and update of our PCOS proteomic biomarker database was performed, along with a parallel review of PE biomarkers. The study included papers from 1980 to December 2013. PARTICIPANTS/MATERIALS, SETTING, METHODS: In all the studies analysed, there were a total of 1423 patients and controls. The number of proteomic biomarkers that were catalogued for PE was 192. MAIN RESULTS AND THE ROLE OF CHANCE: Five proteomic biomarkers were shown to be differentially expressed in women with PE and PCOS when compared with controls: transferrin, fibrinogen α, β and γ chain variants, kininogen-1, annexin 2 and peroxiredoxin 2. In PE, the biomarkers were identified in serum, plasma and placenta and in PCOS, the biomarkers were identified in serum, follicular fluid, and ovarian and omental biopsies. LIMITATIONS, REASONS FOR CAUTION: The techniques employed to detect proteomics have limited ability in identifying proteins that are of low abundance, some of which may have a diagnostic potential. The sample sizes and number of biomarkers identified from these studies do not exclude the risk of false positives, a limitation of all biomarker studies. The biomarkers common to PE and PCOS were identified from proteomic analyses of different tissues. WIDER IMPLICATIONS OF THE FINDINGS: This data amalgamation of the proteomic studies in PE and in PCOS, for the first time, discovered a panel of five biomarkers for PE which are common to women with PCOS, including transferrin, fibrinogen α, β and γ chain variants, kininogen-1, annexin 2 and peroxiredoxin 2. If validated, these biomarkers could provide a useful framework for the knowledge infrastructure in this area. To accomplish this goal, a well co-ordinated multidisciplinary collaboration of clinicians, basic scientists and mathematicians is vital. STUDY FUNDING/COMPETING INTERESTS: No financial support was obtained for this project. There are no conflicts of interest. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/25351721/Overlap_of_proteomics_biomarkers_between_women_with_pre_eclampsia_and_PCOS:_a_systematic_review_and_biomarker_database_integration_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deu268 DB - PRIME DP - Unbound Medicine ER -