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Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study.

Abstract

CONTEXT AND OBJECTIVE

Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients.

DESIGN AND SETTING

Cross-sectional study in a public university hospital.

METHODS

This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011.

RESULTS

Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy.

CONCLUSION

The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence.

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  • Authors+Show Affiliations

    ,

    Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

    ,

    Department of Internal Medicine, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

    ,

    Department of Pathology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

    ,

    Department of Internal Medicine, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

    ,

    Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

    ,

    Department of Internal Medicine, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

    Department of Internal Medicine, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

    Source

    MeSH

    Adult
    Aged
    Autoantibodies
    Biopsy
    Brazil
    Celiac Disease
    Cross-Sectional Studies
    Duodenum
    Female
    Hospitals, Public
    Hospitals, University
    Humans
    Male
    Middle Aged
    Prevalence
    Seroepidemiologic Studies
    Thyroiditis, Autoimmune
    Thyrotropin
    Transglutaminases
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25351758

    Citation

    Ventura, Aline, et al. "Prevalence and Clinical Features of Celiac Disease in Patients With Autoimmune Thyroiditis: Cross-sectional Study." Sao Paulo Medical Journal = Revista Paulista De Medicina, vol. 132, no. 6, 2014, pp. 364-71.
    Ventura A, Ronsoni MF, Shiozawa MB, et al. Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study. Sao Paulo Med J. 2014;132(6):364-71.
    Ventura, A., Ronsoni, M. F., Shiozawa, M. B., Dantas-Corrêa, E. B., Canalli, M. H., Schiavon, L. d. e. . L., & Narciso-Schiavon, J. L. (2014). Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study. Sao Paulo Medical Journal = Revista Paulista De Medicina, 132(6), pp. 364-71.
    Ventura A, et al. Prevalence and Clinical Features of Celiac Disease in Patients With Autoimmune Thyroiditis: Cross-sectional Study. Sao Paulo Med J. 2014;132(6):364-71. PubMed PMID: 25351758.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study. AU - Ventura,Aline, AU - Ronsoni,Marcelo Fernando, AU - Shiozawa,Maria Beatriz Cacese, AU - Dantas-Corrêa,Esther Buzaglo, AU - Canalli,Maria Heloisa Busi da Silva, AU - Schiavon,Leonardo de Lucca, AU - Narciso-Schiavon,Janaína Luz, Y1 - 2014/09/02/ PY - 2013/05/28/received PY - 2013/12/10/accepted PY - 2014/10/30/entrez PY - 2014/10/30/pubmed PY - 2015/5/20/medline SP - 364 EP - 71 JF - Sao Paulo medical journal = Revista paulista de medicina JO - Sao Paulo Med J VL - 132 IS - 6 N2 - CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011. RESULTS: Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy. CONCLUSION: The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence. SN - 1806-9460 UR - https://www.unboundmedicine.com/medline/citation/25351758/Prevalence_and_clinical_features_of_celiac_disease_in_patients_with_autoimmune_thyroiditis:_cross_sectional_study_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000600364&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -