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Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats.
Food Funct. 2015 Jan; 6(1):186-92.FF

Abstract

Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) exert health benefits which are dependent upon their incorporation into blood, cells and tissues. Plasma and tissue deposition of LC n-3 PUFA from oils extracted from the micro-algae Nannochloropsis oculata and from krill were compared in rats. The algal oil provides eicosapentaenoic acid (EPA) partly conjugated (15%) to phospholipids and glycolipids but no docosahexaenoic acid (DHA), whereas krill oil provides both EPA and DHA conjugated in part (40%) to phospholipids. Rats fed a standard diet received either krill oil or polar-lipid rich algal oil by gavage daily for 7 days (5 ml oil per kg body weight each day). Fatty acid concentrations were analyzed in plasma, brain and liver, and two adipose depots since these represent transport, functional and storage pools of fatty acids, respectively. When measuring total LC n-3 PUFA (sum of EPA, docosapentaenoic acid (DPA) and DHA), there was no statistically significant difference between the algal oil and krill oil for plasma, brain, liver and gonadal adipose tissue. Concentrations of LC n-3 PUFA were higher in the retroperitoneal adipose tissue from the algal oil group. Tissue uptake of LC n-3 PUFA from an algal oil containing 15% polar lipids (glycolipids and phospholipids) was found to be equivalent to krill oil containing 40% phospholipids. This may be due to glycolipids forming smaller micelles during ingestive hydrolysis than phospholipids. Ingestion of fatty acids with glycolipids may improve bioavailability, but this needs to be further explored.

Authors+Show Affiliations

Qualitas Health Ltd, 19 Hartom Street, P.O. Box 45423, Jerusalem 91450, Israel. mkagan@qualitas-health.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25360534

Citation

Kagan, Michael L., et al. "Comparative Study of Tissue Deposition of Omega-3 Fatty Acids From Polar-lipid Rich Oil of the Microalgae Nannochloropsis Oculata With Krill Oil in Rats." Food & Function, vol. 6, no. 1, 2015, pp. 186-92.
Kagan ML, Levy A, Leikin-Frenkel A. Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats. Food Funct. 2015;6(1):186-92.
Kagan, M. L., Levy, A., & Leikin-Frenkel, A. (2015). Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats. Food & Function, 6(1), 186-92. https://doi.org/10.1039/c4fo00591k
Kagan ML, Levy A, Leikin-Frenkel A. Comparative Study of Tissue Deposition of Omega-3 Fatty Acids From Polar-lipid Rich Oil of the Microalgae Nannochloropsis Oculata With Krill Oil in Rats. Food Funct. 2015;6(1):186-92. PubMed PMID: 25360534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats. AU - Kagan,Michael L, AU - Levy,Aharon, AU - Leikin-Frenkel,Alicia, Y1 - 2014/10/31/ PY - 2014/11/1/entrez PY - 2014/11/2/pubmed PY - 2015/9/15/medline SP - 186 EP - 92 JF - Food & function JO - Food Funct VL - 6 IS - 1 N2 - Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) exert health benefits which are dependent upon their incorporation into blood, cells and tissues. Plasma and tissue deposition of LC n-3 PUFA from oils extracted from the micro-algae Nannochloropsis oculata and from krill were compared in rats. The algal oil provides eicosapentaenoic acid (EPA) partly conjugated (15%) to phospholipids and glycolipids but no docosahexaenoic acid (DHA), whereas krill oil provides both EPA and DHA conjugated in part (40%) to phospholipids. Rats fed a standard diet received either krill oil or polar-lipid rich algal oil by gavage daily for 7 days (5 ml oil per kg body weight each day). Fatty acid concentrations were analyzed in plasma, brain and liver, and two adipose depots since these represent transport, functional and storage pools of fatty acids, respectively. When measuring total LC n-3 PUFA (sum of EPA, docosapentaenoic acid (DPA) and DHA), there was no statistically significant difference between the algal oil and krill oil for plasma, brain, liver and gonadal adipose tissue. Concentrations of LC n-3 PUFA were higher in the retroperitoneal adipose tissue from the algal oil group. Tissue uptake of LC n-3 PUFA from an algal oil containing 15% polar lipids (glycolipids and phospholipids) was found to be equivalent to krill oil containing 40% phospholipids. This may be due to glycolipids forming smaller micelles during ingestive hydrolysis than phospholipids. Ingestion of fatty acids with glycolipids may improve bioavailability, but this needs to be further explored. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/25360534/Comparative_study_of_tissue_deposition_of_omega_3_fatty_acids_from_polar_lipid_rich_oil_of_the_microalgae_Nannochloropsis_oculata_with_krill_oil_in_rats_ L2 - https://doi.org/10.1039/c4fo00591k DB - PRIME DP - Unbound Medicine ER -