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Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report.
BMC Res Notes. 2014 Nov 05; 7:785.BR

Abstract

BACKGROUND

Drug-induced subacute cutaneous lupus erythematosus is an uncommon disorder associated with the use of pharmacological agents including systemic chemotherapy.

CASE PRESENTATION

We report a case of docetaxel-induced subacute cutaneous lupus erythematosus in a 60-year-old Caucasian female with Sjögren's syndrome diagnosed 2 months after receiving docetaxel as part of the adjuvant FEC-D (5-fluorouracil, epirubicin, cyclophosphamide, docetaxel) chemotherapy protocol for early stage breast cancer. Although the exact mechanisms behind the autoimmune response elicited by docetaxel are unclear, the involvement of anti-SSA/Ro antibodies has been implicated.

CONCLUSION

This case highlights the symptom severity and clinical course of docetaxel-induced subacute cutaneous lupus erythematosus, and highlights the importance of recognizing this uncommon but potentially severe chemotherapy-associated cutaneous reaction.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Oncology, Division of Medical Oncology, University of Calgary, Tom Baker Cancer Centre, 1331 29 St NW, Calgary, Alberta T2N 4N2, Canada. roger.tsang@albertahealthservices.ca.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25369825

Citation

Wong, Noelle Y., et al. "Drug-induced Subacute Cutaneous Lupus Erythematosus Associated With Docetaxel Chemotherapy: a Case Report." BMC Research Notes, vol. 7, 2014, p. 785.
Wong NY, Parsons LM, Trotter MJ, et al. Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report. BMC Res Notes. 2014;7:785.
Wong, N. Y., Parsons, L. M., Trotter, M. J., & Tsang, R. Y. (2014). Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report. BMC Research Notes, 7, 785. https://doi.org/10.1186/1756-0500-7-785
Wong NY, et al. Drug-induced Subacute Cutaneous Lupus Erythematosus Associated With Docetaxel Chemotherapy: a Case Report. BMC Res Notes. 2014 Nov 5;7:785. PubMed PMID: 25369825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report. AU - Wong,Noelle Y, AU - Parsons,Laurie M, AU - Trotter,Martin J, AU - Tsang,Roger Y, Y1 - 2014/11/05/ PY - 2014/05/27/received PY - 2014/10/20/accepted PY - 2014/11/6/entrez PY - 2014/11/6/pubmed PY - 2015/6/27/medline SP - 785 EP - 785 JF - BMC research notes JO - BMC Res Notes VL - 7 N2 - BACKGROUND: Drug-induced subacute cutaneous lupus erythematosus is an uncommon disorder associated with the use of pharmacological agents including systemic chemotherapy. CASE PRESENTATION: We report a case of docetaxel-induced subacute cutaneous lupus erythematosus in a 60-year-old Caucasian female with Sjögren's syndrome diagnosed 2 months after receiving docetaxel as part of the adjuvant FEC-D (5-fluorouracil, epirubicin, cyclophosphamide, docetaxel) chemotherapy protocol for early stage breast cancer. Although the exact mechanisms behind the autoimmune response elicited by docetaxel are unclear, the involvement of anti-SSA/Ro antibodies has been implicated. CONCLUSION: This case highlights the symptom severity and clinical course of docetaxel-induced subacute cutaneous lupus erythematosus, and highlights the importance of recognizing this uncommon but potentially severe chemotherapy-associated cutaneous reaction. SN - 1756-0500 UR - https://www.unboundmedicine.com/medline/citation/25369825/Drug_induced_subacute_cutaneous_lupus_erythematosus_associated_with_docetaxel_chemotherapy:_a_case_report_ DB - PRIME DP - Unbound Medicine ER -