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ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.
Nat Commun. 2014 Nov 05; 5:4984.NC

Abstract

In mammals, pain sensation is initiated by the detection of noxious stimuli through specialized transduction ion channels and receptors in nociceptive sensory neurons. Transient receptor potential (TRP) channels are the key sensory transducers that confer nociceptors distinct sensory modalities. However, the regulatory mechanisms about their expression are poorly defined. Here we show that the zinc-finger protein ZBTB20 regulates TRP channels expression in nociceptors. ZBTB20 is highly expressed in nociceptive sensory neurons of dorsal root ganglia. Disruption of ZBTB20 in nociceptors led to a marked decrease in the expression levels of TRPV1, TRPA1 and TRPM8 and the response of calcium flux and whole-cell currents evoked by their respective specific agonists. Phenotypically, the mice lacking ZBTB20 specifically in nociceptors showed a defect in nociception and pain sensation in response to thermal, mechanical and inflammatory stimulation. Our findings point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channels expression in nociceptors.

Authors+Show Affiliations

Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China.Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China.Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China.1] Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China [2] Department of Cell Biology, Second Military Medical University, Shanghai 200433, China.Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China.Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China.Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China.Biology Department, University College London, Gower Street, London WC1E 6BT, UK.Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68102, USA.Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai 200092, China.Department of Physiology and Neurobiology, Key Lab of Ministry of Education in Fertility Preservation and Maintenance, Ningxia Medical University, Yinchuan 750004, China.1] Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China [2] Department of Cell Biology, Second Military Medical University, Shanghai 200433, China.Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25369838

Citation

Ren, An-Jing, et al. "ZBTB20 Regulates Nociception and Pain Sensation By Modulating TRP Channel Expression in Nociceptive Sensory Neurons." Nature Communications, vol. 5, 2014, p. 4984.
Ren AJ, Wang K, Zhang H, et al. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nat Commun. 2014;5:4984.
Ren, A. J., Wang, K., Zhang, H., Liu, A., Ma, X., Liang, Q., Cao, D., Wood, J. N., He, D. Z., Ding, Y. Q., Yuan, W. J., Xie, Z., & Zhang, W. J. (2014). ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nature Communications, 5, 4984. https://doi.org/10.1038/ncomms5984
Ren AJ, et al. ZBTB20 Regulates Nociception and Pain Sensation By Modulating TRP Channel Expression in Nociceptive Sensory Neurons. Nat Commun. 2014 Nov 5;5:4984. PubMed PMID: 25369838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. AU - Ren,An-Jing, AU - Wang,Kai, AU - Zhang,Huan, AU - Liu,Anjun, AU - Ma,Xianhua, AU - Liang,Qing, AU - Cao,Dongmei, AU - Wood,John N, AU - He,David Z, AU - Ding,Yu-Qiang, AU - Yuan,Wen-Jun, AU - Xie,Zhifang, AU - Zhang,Weiping J, Y1 - 2014/11/05/ PY - 2014/05/19/received PY - 2014/08/14/accepted PY - 2014/11/6/entrez PY - 2014/11/6/pubmed PY - 2015/10/29/medline SP - 4984 EP - 4984 JF - Nature communications JO - Nat Commun VL - 5 N2 - In mammals, pain sensation is initiated by the detection of noxious stimuli through specialized transduction ion channels and receptors in nociceptive sensory neurons. Transient receptor potential (TRP) channels are the key sensory transducers that confer nociceptors distinct sensory modalities. However, the regulatory mechanisms about their expression are poorly defined. Here we show that the zinc-finger protein ZBTB20 regulates TRP channels expression in nociceptors. ZBTB20 is highly expressed in nociceptive sensory neurons of dorsal root ganglia. Disruption of ZBTB20 in nociceptors led to a marked decrease in the expression levels of TRPV1, TRPA1 and TRPM8 and the response of calcium flux and whole-cell currents evoked by their respective specific agonists. Phenotypically, the mice lacking ZBTB20 specifically in nociceptors showed a defect in nociception and pain sensation in response to thermal, mechanical and inflammatory stimulation. Our findings point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channels expression in nociceptors. SN - 2041-1723 UR - https://www.unboundmedicine.com/medline/citation/25369838/ZBTB20_regulates_nociception_and_pain_sensation_by_modulating_TRP_channel_expression_in_nociceptive_sensory_neurons_ L2 - https://doi.org/10.1038/ncomms5984 DB - PRIME DP - Unbound Medicine ER -