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Epidemiology of systemic lupus erythematosus and cutaneous lupus erythematosus in a predominantly white population in the United States.
Arthritis Care Res (Hoboken) 2015; 67(6):817-28AC

Abstract

OBJECTIVE

Epidemiologic studies comparing the incidence and prevalence of systemic lupus erythematosus (SLE) and isolated cutaneous lupus erythematosus (CLE) are few. Olmsted County, Minnesota provides a unique setting for such a study owing to resources of the Rochester Epidemiology Project. We sought to describe and compare the incidence and prevalence of SLE and CLE from 1993-2005.

METHODS

SLE cases were identified from review of medical records and fulfilled the 1982 American College of Rheumatology classification criteria. CLE cases included patients with classic discoid lupus erythematosus, subacute CLE, lupus panniculitis, and bullous lupus erythematosus. Age- and sex-adjusted incidence and prevalence were standardized to the 2000 US white population.

RESULTS

The age- and sex-adjusted incidence of SLE (2.9 per 100,000; 95% confidence interval [95% CI] 2.0-3.7) was similar to that of CLE (4.2 per 100,000; 95% CI 3.1-5.2, P = 0.10). However, the incidence of CLE was 3 times higher than SLE in men (2.4 versus 0.8 per 100,000; P = 0.009). The age- and sex-adjusted prevalence of CLE on January 1, 2006 was higher than that of SLE (70.4 versus 30.5 per 100,000; P < 0.001). The prevalences of CLE and SLE in women were similar, but the prevalence of CLE was higher in men than in women (56.9 versus 1.6 per 100,000; P < 0.001). The incidence of CLE rose steadily with age and peaked at 60-69 years.

CONCLUSION

The incidences of CLE and SLE are similar, but CLE is more common than SLE in men and in older adults. These findings may reflect differences in genetic or environmental etiology of CLE.

Authors+Show Affiliations

Bumrungrad Hospital, Bangkok, Thailand.Mercy Arthritis & Osteoporosis Center, Des Moines, Iowa.Mayo Clinic College of Medicine, Rochester, Minnesota.Medical College of Wisconsin, Milwaukee.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25369985

Citation

Jarukitsopa, Sudumpai, et al. "Epidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus in a Predominantly White Population in the United States." Arthritis Care & Research, vol. 67, no. 6, 2015, pp. 817-28.
Jarukitsopa S, Hoganson DD, Crowson CS, et al. Epidemiology of systemic lupus erythematosus and cutaneous lupus erythematosus in a predominantly white population in the United States. Arthritis Care Res (Hoboken). 2015;67(6):817-28.
Jarukitsopa, S., Hoganson, D. D., Crowson, C. S., Sokumbi, O., Davis, M. D., Michet, C. J., ... Chowdhary, V. R. (2015). Epidemiology of systemic lupus erythematosus and cutaneous lupus erythematosus in a predominantly white population in the United States. Arthritis Care & Research, 67(6), pp. 817-28. doi:10.1002/acr.22502.
Jarukitsopa S, et al. Epidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus in a Predominantly White Population in the United States. Arthritis Care Res (Hoboken). 2015;67(6):817-28. PubMed PMID: 25369985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of systemic lupus erythematosus and cutaneous lupus erythematosus in a predominantly white population in the United States. AU - Jarukitsopa,Sudumpai, AU - Hoganson,Deana D, AU - Crowson,Cynthia S, AU - Sokumbi,Olayemi, AU - Davis,Mark D, AU - Michet,Clement J,Jr AU - Matteson,Eric L, AU - Maradit Kremers,Hilal, AU - Chowdhary,Vaidehi R, PY - 2014/08/15/received PY - 2014/10/08/revised PY - 2014/10/21/accepted PY - 2014/11/6/entrez PY - 2014/11/6/pubmed PY - 2015/8/4/medline SP - 817 EP - 28 JF - Arthritis care & research JO - Arthritis Care Res (Hoboken) VL - 67 IS - 6 N2 - OBJECTIVE: Epidemiologic studies comparing the incidence and prevalence of systemic lupus erythematosus (SLE) and isolated cutaneous lupus erythematosus (CLE) are few. Olmsted County, Minnesota provides a unique setting for such a study owing to resources of the Rochester Epidemiology Project. We sought to describe and compare the incidence and prevalence of SLE and CLE from 1993-2005. METHODS: SLE cases were identified from review of medical records and fulfilled the 1982 American College of Rheumatology classification criteria. CLE cases included patients with classic discoid lupus erythematosus, subacute CLE, lupus panniculitis, and bullous lupus erythematosus. Age- and sex-adjusted incidence and prevalence were standardized to the 2000 US white population. RESULTS: The age- and sex-adjusted incidence of SLE (2.9 per 100,000; 95% confidence interval [95% CI] 2.0-3.7) was similar to that of CLE (4.2 per 100,000; 95% CI 3.1-5.2, P = 0.10). However, the incidence of CLE was 3 times higher than SLE in men (2.4 versus 0.8 per 100,000; P = 0.009). The age- and sex-adjusted prevalence of CLE on January 1, 2006 was higher than that of SLE (70.4 versus 30.5 per 100,000; P < 0.001). The prevalences of CLE and SLE in women were similar, but the prevalence of CLE was higher in men than in women (56.9 versus 1.6 per 100,000; P < 0.001). The incidence of CLE rose steadily with age and peaked at 60-69 years. CONCLUSION: The incidences of CLE and SLE are similar, but CLE is more common than SLE in men and in older adults. These findings may reflect differences in genetic or environmental etiology of CLE. SN - 2151-4658 UR - https://www.unboundmedicine.com/medline/citation/25369985/Epidemiology_of_systemic_lupus_erythematosus_and_cutaneous_lupus_erythematosus_in_a_predominantly_white_population_in_the_United_States_ L2 - https://doi.org/10.1002/acr.22502 DB - PRIME DP - Unbound Medicine ER -