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Contrast sensitivity and foveal microstructure following vitrectomy for epiretinal membrane.
Invest Ophthalmol Vis Sci. 2014 Nov 04; 55(11):7594-600.IO

Abstract

PURPOSE

To evaluate contrast sensitivity (CS) in patients with epiretinal membrane (ERM) following vitrectomy and to investigate the relationship between CS and foveal microstructures with spectral-domain optical coherence tomography (SD-OCT).

METHODS

Thirty-one eyes of 31 patients with ERM were included. We examined CS with a CSV-1000E chart, a logMAR best-corrected visual acuity (BCVA), and foveal microstructure by using SD-OCT before and at 6 months after surgery. From the CS data, the area under the log contrast sensitivity function (AULCSF) was calculated. Based on the OCT images, we quantified the mean thickness of the ganglion cell layer (GCL), the inner nuclear layer (INL), and the outer retinal layer (outer nuclear layer and outer plexiform layer [ONL+OPL]). The status of the photoreceptor inner and outer segment junction (IS/OS) and external limiting membrane (ELM) was also evaluated.

RESULTS

Vitrectomy significantly improved logMAR BCVA and AULCSF. Even in patients with poor improvement of visual acuity (changes in logMAR BCVA by surgery was ≤0.2), postoperative AULCSF significantly increased by treatment (P < 0.05). Postoperative AULCSF showed a significant correlation with preoperative (P < 0.05) and postoperative (P < 0.05) ONL+OPL thickness, whereas other parameters were not relevant. Postoperative logMAR BCVA significantly correlated with postoperative status of IS/OS (P < 0.05) and preoperative ONL+OPL thickness (P < 0.05).

CONCLUSIONS

In patients with ERM, CS improved even though their visual acuity did not recover significantly by vitrectomy. CS was associated with the thickness of outer retinal layer.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25370511

Citation

Sugiura, Yoshimi, et al. "Contrast Sensitivity and Foveal Microstructure Following Vitrectomy for Epiretinal Membrane." Investigative Ophthalmology & Visual Science, vol. 55, no. 11, 2014, pp. 7594-600.
Sugiura Y, Okamoto F, Okamoto Y, et al. Contrast sensitivity and foveal microstructure following vitrectomy for epiretinal membrane. Invest Ophthalmol Vis Sci. 2014;55(11):7594-600.
Sugiura, Y., Okamoto, F., Okamoto, Y., Hiraoka, T., & Oshika, T. (2014). Contrast sensitivity and foveal microstructure following vitrectomy for epiretinal membrane. Investigative Ophthalmology & Visual Science, 55(11), 7594-600. https://doi.org/10.1167/iovs.14-14035
Sugiura Y, et al. Contrast Sensitivity and Foveal Microstructure Following Vitrectomy for Epiretinal Membrane. Invest Ophthalmol Vis Sci. 2014 Nov 4;55(11):7594-600. PubMed PMID: 25370511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contrast sensitivity and foveal microstructure following vitrectomy for epiretinal membrane. AU - Sugiura,Yoshimi, AU - Okamoto,Fumiki, AU - Okamoto,Yoshifumi, AU - Hiraoka,Takahiro, AU - Oshika,Tetsuro, Y1 - 2014/11/04/ PY - 2014/11/6/entrez PY - 2014/11/6/pubmed PY - 2015/1/28/medline KW - contrast sensitivity KW - epiretinal membrane KW - optical coherence tomography SP - 7594 EP - 600 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 55 IS - 11 N2 - PURPOSE: To evaluate contrast sensitivity (CS) in patients with epiretinal membrane (ERM) following vitrectomy and to investigate the relationship between CS and foveal microstructures with spectral-domain optical coherence tomography (SD-OCT). METHODS: Thirty-one eyes of 31 patients with ERM were included. We examined CS with a CSV-1000E chart, a logMAR best-corrected visual acuity (BCVA), and foveal microstructure by using SD-OCT before and at 6 months after surgery. From the CS data, the area under the log contrast sensitivity function (AULCSF) was calculated. Based on the OCT images, we quantified the mean thickness of the ganglion cell layer (GCL), the inner nuclear layer (INL), and the outer retinal layer (outer nuclear layer and outer plexiform layer [ONL+OPL]). The status of the photoreceptor inner and outer segment junction (IS/OS) and external limiting membrane (ELM) was also evaluated. RESULTS: Vitrectomy significantly improved logMAR BCVA and AULCSF. Even in patients with poor improvement of visual acuity (changes in logMAR BCVA by surgery was ≤0.2), postoperative AULCSF significantly increased by treatment (P < 0.05). Postoperative AULCSF showed a significant correlation with preoperative (P < 0.05) and postoperative (P < 0.05) ONL+OPL thickness, whereas other parameters were not relevant. Postoperative logMAR BCVA significantly correlated with postoperative status of IS/OS (P < 0.05) and preoperative ONL+OPL thickness (P < 0.05). CONCLUSIONS: In patients with ERM, CS improved even though their visual acuity did not recover significantly by vitrectomy. CS was associated with the thickness of outer retinal layer. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/25370511/Contrast_sensitivity_and_foveal_microstructure_following_vitrectomy_for_epiretinal_membrane_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-14035 DB - PRIME DP - Unbound Medicine ER -