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Head injury, α-synuclein genetic variability and Parkinson's disease.
Eur J Neurol. 2015 May; 22(5):874-8.EJ

Abstract

BACKGROUND AND PURPOSE

Head injury has been linked to Parkinson's disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. The joint effects of head injuries and SNCA genetic variants were investigated.

METHODS

From 2001 to 2012, 561 incident idiopathic PD cases and 721 population controls from central California were enrolled. Subjects reported on head injuries throughout their lifetime and were assessed for genetic variability in the SNCA 5' region (D4S3481; Rep1) and 3' untranslated region (rs356165). In unconditional logistic regression models adjusted for confounders, interactions between head injuries and genetic risk variants were investigated.

RESULTS

Parkinson's disease risk in individuals with head injury who are carriers of at least one 263 bp allele in D4S3481 or rs356165 variants was 3-4.5-fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and SNCA D4S3481or rs356165 were not statistically significant.

CONCLUSIONS

Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.

Authors+Show Affiliations

Department of Health Care Management, College of Healthcare Administration and Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25370538

Citation

Lee, P C., et al. "Head Injury, Α-synuclein Genetic Variability and Parkinson's Disease." European Journal of Neurology, vol. 22, no. 5, 2015, pp. 874-8.
Lee PC, Bordelon Y, Bronstein J, et al. Head injury, α-synuclein genetic variability and Parkinson's disease. Eur J Neurol. 2015;22(5):874-8.
Lee, P. C., Bordelon, Y., Bronstein, J., Sinsheimer, J. S., Farrer, M., & Ritz, B. (2015). Head injury, α-synuclein genetic variability and Parkinson's disease. European Journal of Neurology, 22(5), 874-8. https://doi.org/10.1111/ene.12585
Lee PC, et al. Head Injury, Α-synuclein Genetic Variability and Parkinson's Disease. Eur J Neurol. 2015;22(5):874-8. PubMed PMID: 25370538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head injury, α-synuclein genetic variability and Parkinson's disease. AU - Lee,P C, AU - Bordelon,Y, AU - Bronstein,J, AU - Sinsheimer,J S, AU - Farrer,M, AU - Ritz,B, Y1 - 2014/11/05/ PY - 2014/04/13/received PY - 2014/08/29/accepted PY - 2014/11/6/entrez PY - 2014/11/6/pubmed PY - 2015/12/15/medline KW - Parkinson's disease KW - gene−environment interaction KW - head injury SP - 874 EP - 8 JF - European journal of neurology JO - Eur J Neurol VL - 22 IS - 5 N2 - BACKGROUND AND PURPOSE: Head injury has been linked to Parkinson's disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. The joint effects of head injuries and SNCA genetic variants were investigated. METHODS: From 2001 to 2012, 561 incident idiopathic PD cases and 721 population controls from central California were enrolled. Subjects reported on head injuries throughout their lifetime and were assessed for genetic variability in the SNCA 5' region (D4S3481; Rep1) and 3' untranslated region (rs356165). In unconditional logistic regression models adjusted for confounders, interactions between head injuries and genetic risk variants were investigated. RESULTS: Parkinson's disease risk in individuals with head injury who are carriers of at least one 263 bp allele in D4S3481 or rs356165 variants was 3-4.5-fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and SNCA D4S3481or rs356165 were not statistically significant. CONCLUSIONS: Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/25370538/Head_injury_α_synuclein_genetic_variability_and_Parkinson's_disease_ L2 - https://doi.org/10.1111/ene.12585 DB - PRIME DP - Unbound Medicine ER -