Tags

Type your tag names separated by a space and hit enter

Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome.
Minerva Ginecol 2014; 66(6):535-42MG

Abstract

AIM

The aim of this paper was to compare serum chemerin levels in nonobese and overweight/obese patients with polycystic ovary syndrome (PCOS) with lean controls.

METHODS

Seventy women with newly diagnosed or untreated PCOS and 38 age-matched nonobese healthy controls were enrolled in the present study. Participants with PCOS were categorized as nonobese (Body Mass Index [BMI] <25 kg/m², N.=36) or overweight/obese (BMI 25-29.9 kg/m² and ≥30 kg/m², respectively, N.=34). Anthropometric, metabolic and hormonal patterns, and serum chemerin were measured.

RESULTS

Serum chemerin tended to be higher in obese PCOS group than in nonobese PCOS women but did not reach statistical significance. Nonobese healthy controls had significantly lower chemerin levels than two PCOS groups (P<0.001). Fasting insulin (P<0.05) and homeostasis model assessment index (P<0.05) were significantly higher in obese women with PCOS than in other two groups. Also, these two parameters were higher in lean patients with PCOS than in healthy controls (P<0.05). In multiple linear regression analyses, chemerin was significantly associated with BMI (β-coefficient =0.336, P<0.01), and triglyceride (β-coefficient =0.298, P<0.05).

CONCLUSION

Chemerin levels were significantly increased not only in obese PCOS women but also in nonobese PCOS women. The physiological significance of elevated serum chemerin in PCOS remains unclear.

Authors+Show Affiliations

Department of Endocrinology and Metabolism Ankara Education and Research Hospital Ankara, Turkey - zehraberberoglu@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25373013

Citation

Ademoglu, E, et al. "Higher Levels of Circulating Chemerin in Both Lean and Obese Patients With Polycystic Ovary Syndrome." Minerva Ginecologica, vol. 66, no. 6, 2014, pp. 535-42.
Ademoglu E, Berberoglu Z, Carlioglu A, et al. Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome. Minerva Ginecol. 2014;66(6):535-42.
Ademoglu, E., Berberoglu, Z., Carlioglu, A., Dellal, F., Gorar, S., Alphan, Z., ... Karakurt, F. (2014). Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome. Minerva Ginecologica, 66(6), pp. 535-42.
Ademoglu E, et al. Higher Levels of Circulating Chemerin in Both Lean and Obese Patients With Polycystic Ovary Syndrome. Minerva Ginecol. 2014;66(6):535-42. PubMed PMID: 25373013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome. AU - Ademoglu,E, AU - Berberoglu,Z, AU - Carlioglu,A, AU - Dellal,F, AU - Gorar,S, AU - Alphan,Z, AU - Uysal,S, AU - Karakurt,F, PY - 2014/11/6/entrez PY - 2014/11/6/pubmed PY - 2015/12/30/medline SP - 535 EP - 42 JF - Minerva ginecologica JO - Minerva Ginecol VL - 66 IS - 6 N2 - AIM: The aim of this paper was to compare serum chemerin levels in nonobese and overweight/obese patients with polycystic ovary syndrome (PCOS) with lean controls. METHODS: Seventy women with newly diagnosed or untreated PCOS and 38 age-matched nonobese healthy controls were enrolled in the present study. Participants with PCOS were categorized as nonobese (Body Mass Index [BMI] <25 kg/m², N.=36) or overweight/obese (BMI 25-29.9 kg/m² and ≥30 kg/m², respectively, N.=34). Anthropometric, metabolic and hormonal patterns, and serum chemerin were measured. RESULTS: Serum chemerin tended to be higher in obese PCOS group than in nonobese PCOS women but did not reach statistical significance. Nonobese healthy controls had significantly lower chemerin levels than two PCOS groups (P<0.001). Fasting insulin (P<0.05) and homeostasis model assessment index (P<0.05) were significantly higher in obese women with PCOS than in other two groups. Also, these two parameters were higher in lean patients with PCOS than in healthy controls (P<0.05). In multiple linear regression analyses, chemerin was significantly associated with BMI (β-coefficient =0.336, P<0.01), and triglyceride (β-coefficient =0.298, P<0.05). CONCLUSION: Chemerin levels were significantly increased not only in obese PCOS women but also in nonobese PCOS women. The physiological significance of elevated serum chemerin in PCOS remains unclear. SN - 1827-1650 UR - https://www.unboundmedicine.com/medline/citation/25373013/Higher_levels_of_circulating_chemerin_in_both_lean_and_obese_patients_with_polycystic_ovary_syndrome_ L2 - http://www.minervamedica.it/index2.t?show=R09Y2014N06A0535 DB - PRIME DP - Unbound Medicine ER -