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The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome.
Gynecol Endocrinol. 2015 Mar; 31(3):225-8.GE

Abstract

OBJECTIVE

To evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI).

METHODS

Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n = 12), II (non-eutrophic without PCOS, n = 10), III (eutrophic with PCOS, n = 8) and IV (eutrophic without PCOS, n = 10) being non-eutrophic, the overweight and obese women with BMI > 25 kg/m2 and eutrophic women with BMI < 24.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR.

RESULTS

PCOS patients showed increased levels of CRP (p < 0.01) and HOMA-IR (p < 0.01). When divided by BMI, both non-eutrophicad eutrophic PCOS showed increased CRP levels (p < 0.01) and HOMA-IR (p < 0.01). There were no differences in TNF-α and IL-6 levels between groups.

CONCLUSION

In the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass.

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Authors+Show Affiliations

Souza Dos Santos AC
Graduate Program in Pharmaceutical Sciences - CCS , Natal, RN , Brazil .
Soares NP
No affiliation info available
Costa EC
No affiliation info available
de Sá JC
No affiliation info available
Azevedo GD
No affiliation info available
Lemos TM
No affiliation info available

MeSH

AdolescentAdultBiomarkersBlood GlucoseBody Mass IndexC-Reactive ProteinFemaleHumansInflammationInsulinInsulin ResistanceInterleukin-6Polycystic Ovary SyndromeTumor Necrosis Factor-alphaYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25373529

Citation

Souza Dos Santos, Ana Celly, et al. "The Impact of Body Mass On Inflammatory Markers and Insulin Resistance in Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 31, no. 3, 2015, pp. 225-8.
Souza Dos Santos AC, Soares NP, Costa EC, et al. The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome. Gynecol Endocrinol. 2015;31(3):225-8.
Souza Dos Santos, A. C., Soares, N. P., Costa, E. C., de Sá, J. C., Azevedo, G. D., & Lemos, T. M. (2015). The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 31(3), 225-8. https://doi.org/10.3109/09513590.2014.976546
Souza Dos Santos AC, et al. The Impact of Body Mass On Inflammatory Markers and Insulin Resistance in Polycystic Ovary Syndrome. Gynecol Endocrinol. 2015;31(3):225-8. PubMed PMID: 25373529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome. AU - Souza Dos Santos,Ana Celly, AU - Soares,Nayara Pereira, AU - Costa,Eduardo Caldas, AU - de Sá,Joceline Cássia Ferrezini, AU - Azevedo,George Dantas, AU - Lemos,Telma Maria Araújo Moura, Y1 - 2014/11/06/ PY - 2014/11/7/entrez PY - 2014/11/7/pubmed PY - 2016/3/24/medline KW - Cytokines KW - inflammation KW - insulin resistance KW - nutritional status KW - obesity KW - ovary KW - polycystic ovary syndrome SP - 225 EP - 8 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 31 IS - 3 N2 - OBJECTIVE: To evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI). METHODS: Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n = 12), II (non-eutrophic without PCOS, n = 10), III (eutrophic with PCOS, n = 8) and IV (eutrophic without PCOS, n = 10) being non-eutrophic, the overweight and obese women with BMI > 25 kg/m2 and eutrophic women with BMI < 24.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR. RESULTS: PCOS patients showed increased levels of CRP (p < 0.01) and HOMA-IR (p < 0.01). When divided by BMI, both non-eutrophicad eutrophic PCOS showed increased CRP levels (p < 0.01) and HOMA-IR (p < 0.01). There were no differences in TNF-α and IL-6 levels between groups. CONCLUSION: In the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/25373529/The_impact_of_body_mass_on_inflammatory_markers_and_insulin_resistance_in_polycystic_ovary_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513590.2014.976546 DB - PRIME DP - Unbound Medicine ER -