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Risk factors of caregiver burden among patients with Alzheimer's disease or related disorders: a cross-sectional study.
J Alzheimers Dis. 2015; 44(3):907-16.JA

Abstract

BACKGROUND

Caregivers play a major role in the care of patients with dementia and are themselves at higher risk of disease.

OBJECTIVES

We investigate which factors are associated with caregivers burden of outpatients visiting a memory clinic and how functional autonomy and behavioral and psychological symptoms can influence caregiver burden.

METHODS

The study population was chosen from outpatients with progressive cognitive complaint. The caregiver burden was measured with the short version of the Zarit Burden Interview (ZBI). The relationship was assessed between the ZBI and the patients characteristics, including Neuropsychiatric Inventory (NPI), Instrumental Activities of Daily Living scale (IADL), the Mini-Mental State Examination (MMSE), etiology, and stage of the cognitive impairment.

RESULTS

In a population of 548 patients, IADL, NPI, antidepressant drugs, and MMSE were found to be related to ZBI, while diagnosed etiology and disease stage were not significant: ZBI decreased by 0.34 point for every unit of IADL, and by 0.03 point for every unit of MMSE; ZBI increased by 0.03 point for every unit of NPI. From the IADL scale, the ability to handle finances, food preparation, responsibility to take medications, mode of transportation, and ability to use the telephone increased the ZBI. Five areas of the NPI increased the ZBI: apathy, agitation, aberrant motor behavior, appetite disorders (p < 0.001), and irritability (p = 0.03).

CONCLUSION

Caregivers experience a higher burden due to disease symptoms such as impairment of functional autonomy and behavioral and cognitive impairment, whatever the etiology of the cognitive decline.

Authors+Show Affiliations

Memory Research Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France.Memory Research Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France.Research Clinic Centre (CRC) - VCF (Aging - Brain - Frailty), Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France University Hospital of Lyon, Pharmaceutical Unit, Lyon, France University Lyon 1, INSERM, U1028, UMR CNRS 5292, Research Centre of Neurosciences of Lyon, Lyon, France.Memory Research Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France.Memory Research Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France.Memory Research Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France.Memory Research Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France Neurology Unit, University Hospital of Saint-Etienne, Saint Etienne, France.Memory Research Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France Research Clinic Centre (CRC) - VCF (Aging - Brain - Frailty), Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France University Lyon 1, INSERM, U1028, UMR CNRS 5292, Research Centre of Neurosciences of Lyon, Lyon, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25374109

Citation

Dauphinot, Virginie, et al. "Risk Factors of Caregiver Burden Among Patients With Alzheimer's Disease or Related Disorders: a Cross-sectional Study." Journal of Alzheimer's Disease : JAD, vol. 44, no. 3, 2015, pp. 907-16.
Dauphinot V, Delphin-Combe F, Mouchoux C, et al. Risk factors of caregiver burden among patients with Alzheimer's disease or related disorders: a cross-sectional study. J Alzheimers Dis. 2015;44(3):907-16.
Dauphinot, V., Delphin-Combe, F., Mouchoux, C., Dorey, A., Bathsavanis, A., Makaroff, Z., Rouch, I., & Krolak-Salmon, P. (2015). Risk factors of caregiver burden among patients with Alzheimer's disease or related disorders: a cross-sectional study. Journal of Alzheimer's Disease : JAD, 44(3), 907-16. https://doi.org/10.3233/JAD-142337
Dauphinot V, et al. Risk Factors of Caregiver Burden Among Patients With Alzheimer's Disease or Related Disorders: a Cross-sectional Study. J Alzheimers Dis. 2015;44(3):907-16. PubMed PMID: 25374109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors of caregiver burden among patients with Alzheimer's disease or related disorders: a cross-sectional study. AU - Dauphinot,Virginie, AU - Delphin-Combe,Floriane, AU - Mouchoux,Christelle, AU - Dorey,Aline, AU - Bathsavanis,Anthony, AU - Makaroff,Zaza, AU - Rouch,Isabelle, AU - Krolak-Salmon,Pierre, PY - 2014/11/7/entrez PY - 2014/11/7/pubmed PY - 2015/10/27/medline KW - Alzheimer's disease or related disorder KW - behavioral disorders KW - caregiver KW - dementia KW - dependency KW - elderly SP - 907 EP - 16 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 44 IS - 3 N2 - BACKGROUND: Caregivers play a major role in the care of patients with dementia and are themselves at higher risk of disease. OBJECTIVES: We investigate which factors are associated with caregivers burden of outpatients visiting a memory clinic and how functional autonomy and behavioral and psychological symptoms can influence caregiver burden. METHODS: The study population was chosen from outpatients with progressive cognitive complaint. The caregiver burden was measured with the short version of the Zarit Burden Interview (ZBI). The relationship was assessed between the ZBI and the patients characteristics, including Neuropsychiatric Inventory (NPI), Instrumental Activities of Daily Living scale (IADL), the Mini-Mental State Examination (MMSE), etiology, and stage of the cognitive impairment. RESULTS: In a population of 548 patients, IADL, NPI, antidepressant drugs, and MMSE were found to be related to ZBI, while diagnosed etiology and disease stage were not significant: ZBI decreased by 0.34 point for every unit of IADL, and by 0.03 point for every unit of MMSE; ZBI increased by 0.03 point for every unit of NPI. From the IADL scale, the ability to handle finances, food preparation, responsibility to take medications, mode of transportation, and ability to use the telephone increased the ZBI. Five areas of the NPI increased the ZBI: apathy, agitation, aberrant motor behavior, appetite disorders (p < 0.001), and irritability (p = 0.03). CONCLUSION: Caregivers experience a higher burden due to disease symptoms such as impairment of functional autonomy and behavioral and cognitive impairment, whatever the etiology of the cognitive decline. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25374109/Risk_factors_of_caregiver_burden_among_patients_with_Alzheimer's_disease_or_related_disorders:_a_cross_sectional_study_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-142337 DB - PRIME DP - Unbound Medicine ER -