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The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: An emerging public health problem.
J Family Community Med 2014; 21(3):154-61JF

Abstract

BACKGROUND

Vitamin D deficiency has been declared a public health problem for both adults and children worldwide. Asthma and related allergic diseases are the leading causes of morbidity in children. The objective of this study was to investigate the potential role of Vitamin D deficiency in childhood asthma and other allergic diseases such as allergic rhinitis and wheezing.

MATERIALS AND METHODS

This cross-sectional study was conducted in Primary Health Care Centers (PHCs), from March 2012 to October 2013. A total of 2350 Qatari children below the age of 16 were selected from PHCs, and 1833 agreed to participate in this study giving a response rate of (78%). Face-to-face interviews with parents of all the children were based on a questionnaire that included variables such as socio-demographic information, assessment of nondietary covariates, Vitamin D intake, type of feeding, and laboratory investigations. Their health status was assessed by serum Vitamin D (25-hydoxyvitamin D), family history and body mass index.

RESULTS

Most of the children who had asthma (38.5%), allergic rhinitis (34.8%) and wheezing (35.7%) were below 5 years. Consanguinity was significantly higher in parents of children with allergic rhinitis (48.6%), followed by those with asthma (46.4%) and wheezing (40.8%) than in healthy children (35.9%) (P < 0.001). The proportion of severe Vitamin D deficiency was significantly higher in children with wheezing (23.4%), allergic rhinitis (18.5%), and asthma (17%) than in healthy children (10.5%). Exposure to the sun was significantly less in Vitamin D deficient children with asthma (60.3%), allergic rhinitis (62.5%) and wheezing (64.4%) than in controls (47.1%) (P = 0.008). It was found that Vitamin D deficiency was a significant correlate for asthma (odds ratio [OR] =2.31; P < 0.001), allergic rhinitis (OR = 1.59; P < 0.001) and wheezing (relative risk = 1.29; P = 0.05).

CONCLUSION

The study findings revealed a high prevalence of Vitamin D deficiency in children with asthma and allergic diseases. Vitamin D deficiency was a strong correlate for asthma, allergic rhinitis and wheezing.

Authors+Show Affiliations

Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, University of Manchester, Manchester, UK ; Department of Public Health, Weill Cornell Medical College, Ar-Rayyan, State of Qatar, University of Manchester, Manchester, UK ; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK.Department of Pediatrics, Section of Pediatric Allergy and Immunology, Hamad Medical Corporation, Doha, State of Qatar ; Department of Paediatrics, Weill Cornell Medical College, Ar-Rayyan, State of Qatar.Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, University of Manchester, Manchester, UK ; Department of Public Health, Weill Cornell Medical College, Ar-Rayyan, State of Qatar, University of Manchester, Manchester, UK.Strauss Chair in Respiratory Medicine, Meakins-Christie Laboratories, McGill University, Montreal, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25374465

Citation

Bener, Abdulbari, et al. "The Impact of Vitamin D Deficiency On Asthma, Allergic Rhinitis and Wheezing in Children: an Emerging Public Health Problem." Journal of Family & Community Medicine, vol. 21, no. 3, 2014, pp. 154-61.
Bener A, Ehlayel MS, Bener HZ, et al. The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: An emerging public health problem. J Family Community Med. 2014;21(3):154-61.
Bener, A., Ehlayel, M. S., Bener, H. Z., & Hamid, Q. (2014). The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: An emerging public health problem. Journal of Family & Community Medicine, 21(3), pp. 154-61. doi:10.4103/2230-8229.142967.
Bener A, et al. The Impact of Vitamin D Deficiency On Asthma, Allergic Rhinitis and Wheezing in Children: an Emerging Public Health Problem. J Family Community Med. 2014;21(3):154-61. PubMed PMID: 25374465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: An emerging public health problem. AU - Bener,Abdulbari, AU - Ehlayel,Mohammad S, AU - Bener,Hale Z, AU - Hamid,Qutayba, PY - 2014/11/7/entrez PY - 2014/11/7/pubmed PY - 2014/11/7/medline KW - Allergic rhinitis KW - Qatar KW - Vitamin D KW - asthma KW - children KW - predictors KW - wheezing SP - 154 EP - 61 JF - Journal of family & community medicine JO - J Family Community Med VL - 21 IS - 3 N2 - BACKGROUND: Vitamin D deficiency has been declared a public health problem for both adults and children worldwide. Asthma and related allergic diseases are the leading causes of morbidity in children. The objective of this study was to investigate the potential role of Vitamin D deficiency in childhood asthma and other allergic diseases such as allergic rhinitis and wheezing. MATERIALS AND METHODS: This cross-sectional study was conducted in Primary Health Care Centers (PHCs), from March 2012 to October 2013. A total of 2350 Qatari children below the age of 16 were selected from PHCs, and 1833 agreed to participate in this study giving a response rate of (78%). Face-to-face interviews with parents of all the children were based on a questionnaire that included variables such as socio-demographic information, assessment of nondietary covariates, Vitamin D intake, type of feeding, and laboratory investigations. Their health status was assessed by serum Vitamin D (25-hydoxyvitamin D), family history and body mass index. RESULTS: Most of the children who had asthma (38.5%), allergic rhinitis (34.8%) and wheezing (35.7%) were below 5 years. Consanguinity was significantly higher in parents of children with allergic rhinitis (48.6%), followed by those with asthma (46.4%) and wheezing (40.8%) than in healthy children (35.9%) (P < 0.001). The proportion of severe Vitamin D deficiency was significantly higher in children with wheezing (23.4%), allergic rhinitis (18.5%), and asthma (17%) than in healthy children (10.5%). Exposure to the sun was significantly less in Vitamin D deficient children with asthma (60.3%), allergic rhinitis (62.5%) and wheezing (64.4%) than in controls (47.1%) (P = 0.008). It was found that Vitamin D deficiency was a significant correlate for asthma (odds ratio [OR] =2.31; P < 0.001), allergic rhinitis (OR = 1.59; P < 0.001) and wheezing (relative risk = 1.29; P = 0.05). CONCLUSION: The study findings revealed a high prevalence of Vitamin D deficiency in children with asthma and allergic diseases. Vitamin D deficiency was a strong correlate for asthma, allergic rhinitis and wheezing. SN - 1319-1683 UR - https://www.unboundmedicine.com/medline/citation/25374465/full_citation L2 - http://www.jfcmonline.com/article.asp?issn=2230-8229;year=2014;volume=21;issue=3;spage=154;epage=161;aulast=Bener DB - PRIME DP - Unbound Medicine ER -