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Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study.
Med Sci Monit. 2014 Nov 06; 20:2183-8.MS

Abstract

BACKGROUND

Statin use is frequently associated with muscle-related symptoms. Coenzyme Q10 supplementation has yielded conflicting results in decreasing statin myopathy. Herein, we tested whether coenzyme Q10 supplementation could decrease statin-associated muscular pain in a specific group of patients with mild-to-moderate muscle symptoms.

MATERIAL/METHODS

Fifty patients treated with statins and reporting muscle pain were recruited. The Q10 group (n=25) received coenzyme Q10 supplementation over a period of 30 days (50 mg twice daily), and the control group (n=25) received placebo. The Brief Pain Inventory (BPI) questionnaire was used and blood testing was performed at inclusion in the study and after 30 days of supplementation.

RESULTS

The intensity of muscle pain, measured as the Pain Severity Score (PSS), in the Q10 group was reduced from 3.9±0.4 to 2.9±0.4 (P<0.001). The Pain Interference Score (PIS) after Q10 supplementation was reduced from 4.0±0.4 to 2.6±0.4 (P<0.001). In the placebo group, PSS and PIS did not change. Coenzyme Q10 supplementation decreased statin-related muscle symptoms in 75% of patients. The relative values of PSS and PIS significantly decreased (-33.1% and -40.3%, respectively) in the Q10 group compared to placebo group (both P<0.05). From baseline, no differences in liver and muscle enzymes or cholesterol values were found.

CONCLUSIONS

The present results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin-related muscular symptoms with daily activities.

Authors+Show Affiliations

Department of Vascular Diseases, University of Ljubljana Medical Centre, Ljubljana, Slovenia.Department of Vascular Diseases, University of Ljubljana Medical Centre, Ljubljana, Slovenia.Department of Vascular Diseases, University of Ljubljana Medical Centre, Ljubljana, Slovenia.Department of Vascular Diseases, University of Ljubljana Medical Centre, Ljubljana, Slovenia.Department of Vascular Diseases, University of Ljubljana Medical Centre, Ljubljana, Slovenia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25375075

Citation

Skarlovnik, Ajda, et al. "Coenzyme Q10 Supplementation Decreases Statin-related Mild-to-moderate Muscle Symptoms: a Randomized Clinical Study." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 20, 2014, pp. 2183-8.
Skarlovnik A, Janić M, Lunder M, et al. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Med Sci Monit. 2014;20:2183-8.
Skarlovnik, A., Janić, M., Lunder, M., Turk, M., & Šabovič, M. (2014). Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 20, 2183-8. https://doi.org/10.12659/MSM.890777
Skarlovnik A, et al. Coenzyme Q10 Supplementation Decreases Statin-related Mild-to-moderate Muscle Symptoms: a Randomized Clinical Study. Med Sci Monit. 2014 Nov 6;20:2183-8. PubMed PMID: 25375075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. AU - Skarlovnik,Ajda, AU - Janić,Miodrag, AU - Lunder,Mojca, AU - Turk,Martina, AU - Šabovič,Mišo, Y1 - 2014/11/06/ PY - 2014/11/7/entrez PY - 2014/11/7/pubmed PY - 2015/6/30/medline SP - 2183 EP - 8 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 20 N2 - BACKGROUND: Statin use is frequently associated with muscle-related symptoms. Coenzyme Q10 supplementation has yielded conflicting results in decreasing statin myopathy. Herein, we tested whether coenzyme Q10 supplementation could decrease statin-associated muscular pain in a specific group of patients with mild-to-moderate muscle symptoms. MATERIAL/METHODS: Fifty patients treated with statins and reporting muscle pain were recruited. The Q10 group (n=25) received coenzyme Q10 supplementation over a period of 30 days (50 mg twice daily), and the control group (n=25) received placebo. The Brief Pain Inventory (BPI) questionnaire was used and blood testing was performed at inclusion in the study and after 30 days of supplementation. RESULTS: The intensity of muscle pain, measured as the Pain Severity Score (PSS), in the Q10 group was reduced from 3.9±0.4 to 2.9±0.4 (P<0.001). The Pain Interference Score (PIS) after Q10 supplementation was reduced from 4.0±0.4 to 2.6±0.4 (P<0.001). In the placebo group, PSS and PIS did not change. Coenzyme Q10 supplementation decreased statin-related muscle symptoms in 75% of patients. The relative values of PSS and PIS significantly decreased (-33.1% and -40.3%, respectively) in the Q10 group compared to placebo group (both P<0.05). From baseline, no differences in liver and muscle enzymes or cholesterol values were found. CONCLUSIONS: The present results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin-related muscular symptoms with daily activities. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/25375075/Coenzyme_Q10_supplementation_decreases_statin_related_mild_to_moderate_muscle_symptoms:_a_randomized_clinical_study_ L2 - https://www.medscimonit.com/download/index/idArt/890777 DB - PRIME DP - Unbound Medicine ER -