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Pancreatic main-duct involvement in branch-duct IPMNs: an underestimated risk.
Ann Surg 2014; 260(5):848-55; discussion 855-6AnnS

Abstract

OBJECTIVES

This study aimed to analyze a large single-center population of resected intraductal papillary mucinous neoplasms (IPMN) of the pancreas with respect to risk factors of malignant transformation.

BACKGROUND

There is international consensus that main-duct (MD) as well as mixed-type IPMNs should be treated surgically due to a high risk of malignancy. In contrast, there is an ongoing controversy about surgery of branch-duct type IPMN (BD-IPMN).

METHODS

All consecutive patients who underwent surgery for IPMN between January 2004 and December 2012 were included. Clinical characteristics and preoperative imaging were correlated with histopathological features.

RESULTS

A total of 512 patients underwent pancreatic surgery and had a histological proof of IPMN. According to preoperative imaging, 74 patients had MD-IPMN (14%), 205 mixed-type (40%), and 233 suspected BD-IPMN (46%). On histopathology, 162 of 512 patients revealed low-grade, 105 moderate, and 52 high-grade dysplasia. One hundred ninety-three IPMN patients (38%) suffered from invasive carcinoma. Among invasive IPMNs, the majority (58%) were mixed-type lesions according to preoperative imaging. Of 141 Sendai negative BD-IPMNs, a malignancy rate of 18% (high-grade dysplasia and invasive carcinoma) was found. Most interesting, 29% of suspected BD-IPMNs (67/233) revealed histological involvement of the main pancreatic duct not evident in preoperative imaging.

CONCLUSIONS

All subtypes of IPMNs display a relevant risk for malignant transformation. By abdominal imaging, many IPMNs are misclassified as BD-IPMNs but reveal mixed-type lesions in histopathology. Because currently available preoperative diagnostics are not sufficient to reliably diagnose BD-IPMNs, surgical resection for suspected small branch-duct IPMN should be considered in patients fit for surgery.

Authors+Show Affiliations

*Department of General, Visceral and Transplantation Surgery †Department of Diagnostic and Interventional Radiology ‡Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25379856

Citation

Fritz, Stefan, et al. "Pancreatic Main-duct Involvement in Branch-duct IPMNs: an Underestimated Risk." Annals of Surgery, vol. 260, no. 5, 2014, pp. 848-55; discussion 855-6.
Fritz S, Klauss M, Bergmann F, et al. Pancreatic main-duct involvement in branch-duct IPMNs: an underestimated risk. Ann Surg. 2014;260(5):848-55; discussion 855-6.
Fritz, S., Klauss, M., Bergmann, F., Strobel, O., Schneider, L., Werner, J., ... Büchler, M. W. (2014). Pancreatic main-duct involvement in branch-duct IPMNs: an underestimated risk. Annals of Surgery, 260(5), pp. 848-55; discussion 855-6. doi:10.1097/SLA.0000000000000980.
Fritz S, et al. Pancreatic Main-duct Involvement in Branch-duct IPMNs: an Underestimated Risk. Ann Surg. 2014;260(5):848-55; discussion 855-6. PubMed PMID: 25379856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic main-duct involvement in branch-duct IPMNs: an underestimated risk. AU - Fritz,Stefan, AU - Klauss,Miriam, AU - Bergmann,Frank, AU - Strobel,Oliver, AU - Schneider,Lutz, AU - Werner,Jens, AU - Hackert,Thilo, AU - Büchler,Markus W, PY - 2014/11/8/entrez PY - 2014/11/8/pubmed PY - 2015/4/2/medline SP - 848-55; discussion 855-6 JF - Annals of surgery JO - Ann. Surg. VL - 260 IS - 5 N2 - OBJECTIVES: This study aimed to analyze a large single-center population of resected intraductal papillary mucinous neoplasms (IPMN) of the pancreas with respect to risk factors of malignant transformation. BACKGROUND: There is international consensus that main-duct (MD) as well as mixed-type IPMNs should be treated surgically due to a high risk of malignancy. In contrast, there is an ongoing controversy about surgery of branch-duct type IPMN (BD-IPMN). METHODS: All consecutive patients who underwent surgery for IPMN between January 2004 and December 2012 were included. Clinical characteristics and preoperative imaging were correlated with histopathological features. RESULTS: A total of 512 patients underwent pancreatic surgery and had a histological proof of IPMN. According to preoperative imaging, 74 patients had MD-IPMN (14%), 205 mixed-type (40%), and 233 suspected BD-IPMN (46%). On histopathology, 162 of 512 patients revealed low-grade, 105 moderate, and 52 high-grade dysplasia. One hundred ninety-three IPMN patients (38%) suffered from invasive carcinoma. Among invasive IPMNs, the majority (58%) were mixed-type lesions according to preoperative imaging. Of 141 Sendai negative BD-IPMNs, a malignancy rate of 18% (high-grade dysplasia and invasive carcinoma) was found. Most interesting, 29% of suspected BD-IPMNs (67/233) revealed histological involvement of the main pancreatic duct not evident in preoperative imaging. CONCLUSIONS: All subtypes of IPMNs display a relevant risk for malignant transformation. By abdominal imaging, many IPMNs are misclassified as BD-IPMNs but reveal mixed-type lesions in histopathology. Because currently available preoperative diagnostics are not sufficient to reliably diagnose BD-IPMNs, surgical resection for suspected small branch-duct IPMN should be considered in patients fit for surgery. SN - 1528-1140 UR - https://www.unboundmedicine.com/medline/citation/25379856/Pancreatic_main_duct_involvement_in_branch_duct_IPMNs:_an_underestimated_risk_ L2 - http://Insights.ovid.com/pubmed?pmid=25379856 DB - PRIME DP - Unbound Medicine ER -