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Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials.
BMJ Open 2014; 4(11):e006140BO

Abstract

OBJECTIVE

To assess the clinical evidence for bee venom acupuncture (BVA) for rheumatoid arthritis (RA).

DESIGN

Systematic review of randomised controlled trials (RCTs).

SETTING

We searched 14 databases up to March 2014 without a language restriction.

PARTICIPANTS

Patients with RA.

INTERVENTION

BVA involved injecting purified, diluted BV into acupoints. We included trials on BVA used alone or in combination with a conventional therapy versus the conventional therapy alone.

PRIMARY OUTCOMES

Morning stiffness, pain and joint swelling

SECONDARY OUTCOMES

Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor, the number of joints affected by RA and adverse effects likely related to RA.

RESULTS

A total of 304 potentially relevant studies were identified; only one RCT met our inclusion criteria. Compared with placebo, BVA may more effectively improve joint pain, swollen joint counts, tender joint counts, ESR and CRP but was not shown to improve morning stiffness.

CONCLUSIONS

There is low-quality evidence, based on one trial, that BVA can significantly reduce pain, morning stiffness, tender joint counts, swollen joint counts and improve the quality of life of patients with RA compared with placebo (normal saline injection) control. However, the number of trials, their quality and the total sample size were too low to draw firm conclusions.

TRIAL REGISTRATION NUMBER

PROSPERO 2013: CRD42013005853.

Authors+Show Affiliations

Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.Medical Culture & Informatics Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.Division of Acupuncture & Moxibustion Medicine, Kyung Hee Korean Medicine Hospital, Kyung Hee University, Seoul, South Korea.Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

25380812

Citation

Lee, Ju Ah, et al. "Bee Venom Acupuncture for Rheumatoid Arthritis: a Systematic Review of Randomised Clinical Trials." BMJ Open, vol. 4, no. 11, 2014, pp. e006140.
Lee JA, Son MJ, Choi J, et al. Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials. BMJ Open. 2014;4(11):e006140.
Lee, J. A., Son, M. J., Choi, J., Jun, J. H., Kim, J. I., & Lee, M. S. (2014). Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials. BMJ Open, 4(11), pp. e006140. doi:10.1136/bmjopen-2014-006140.
Lee JA, et al. Bee Venom Acupuncture for Rheumatoid Arthritis: a Systematic Review of Randomised Clinical Trials. BMJ Open. 2014 Nov 7;4(11):e006140. PubMed PMID: 25380812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials. AU - Lee,Ju Ah, AU - Son,Mi Ju, AU - Choi,Jiae, AU - Jun,Ji Hee, AU - Kim,Jong-In, AU - Lee,Myeong Soo, Y1 - 2014/11/07/ PY - 2014/11/9/entrez PY - 2014/11/9/pubmed PY - 2015/7/1/medline KW - COMPLEMENTARY MEDICINE SP - e006140 EP - e006140 JF - BMJ open JO - BMJ Open VL - 4 IS - 11 N2 - OBJECTIVE: To assess the clinical evidence for bee venom acupuncture (BVA) for rheumatoid arthritis (RA). DESIGN: Systematic review of randomised controlled trials (RCTs). SETTING: We searched 14 databases up to March 2014 without a language restriction. PARTICIPANTS: Patients with RA. INTERVENTION: BVA involved injecting purified, diluted BV into acupoints. We included trials on BVA used alone or in combination with a conventional therapy versus the conventional therapy alone. PRIMARY OUTCOMES: Morning stiffness, pain and joint swelling SECONDARY OUTCOMES: Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor, the number of joints affected by RA and adverse effects likely related to RA. RESULTS: A total of 304 potentially relevant studies were identified; only one RCT met our inclusion criteria. Compared with placebo, BVA may more effectively improve joint pain, swollen joint counts, tender joint counts, ESR and CRP but was not shown to improve morning stiffness. CONCLUSIONS: There is low-quality evidence, based on one trial, that BVA can significantly reduce pain, morning stiffness, tender joint counts, swollen joint counts and improve the quality of life of patients with RA compared with placebo (normal saline injection) control. However, the number of trials, their quality and the total sample size were too low to draw firm conclusions. TRIAL REGISTRATION NUMBER: PROSPERO 2013: CRD42013005853. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/25380812/Bee_venom_acupuncture_for_rheumatoid_arthritis:_a_systematic_review_of_randomised_clinical_trials_ L2 - http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=25380812 DB - PRIME DP - Unbound Medicine ER -