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Randomized controlled trial on the efficacy of new alcohol-free chlorhexidine mouthrinses after 8 weeks.
Int J Dent Hyg 2015; 13(2):110-6IJ

Abstract

OBJECTIVES

To evaluate the efficacy of two alcohol-free antimicrobial mouthrinses in reducing plaque and gingivitis compared to an alcohol-containing rinse and toothbrushing alone.

METHODS

One hundred and sixty healthy volunteers were enrolled in the randomized controlled trial. Participants were randomly and equally assigned to four groups: (i) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-containing rinse, positive control); (ii) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-free experimental rinse); (iii) toothbrushing + rinsing (0.06% CHX + 0.03% CPC + 0.025% NaF, alcohol-free experimental rinse); (iv) toothbrushing alone (negative control). At baseline, Quigley-Hein plaque index (QHI), modified proximal plaque index (MPPI), and papillary bleeding index (PBI) were recorded. All subjects brushed their teeth as usual during the study. Additionally, groups 1-3 rinsed twice daily. Eight weeks after baseline, indices were recorded again. anova with Bonferroni adjustment served for statistical analysis.

RESULTS

One hundred and fifty-five participants were included into final analysis (i: n = 39, 2: n = 39, 3: n = 37, 4: n = 40). Experimental rinses (ii, iii) reduced QHI and MPPI to a higher extent than the negative control (iv), whereas no significant difference to the positive control was found. QHI: (i) 36.6%, (ii) 32.3%, (iii) 36.8%, (iv) 21.6%; MPPI: (i) 11.9%, (ii) 12.2%, (iii) 13.6%, (iv) 3.5%. For PBI, no statistically significant difference was found between groups: (i) 80.2%, (ii) 77.8%, (iii) 76.5% and (iv) 78.8%.

CONCLUSIONS

With respect to QHI and MPPI, toothbrushing in combination with any rinse was more effective than toothbrushing alone. No statistically significant differences were found between the alcohol-free and the alcohol-containing control rinses.

Authors+Show Affiliations

Faculty of Health, Department of Operative and Preventive Dentistry, Witten/Herdecke University, Witten, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25382448

Citation

Zimmer, S, et al. "Randomized Controlled Trial On the Efficacy of New Alcohol-free Chlorhexidine Mouthrinses After 8 Weeks." International Journal of Dental Hygiene, vol. 13, no. 2, 2015, pp. 110-6.
Zimmer S, Korte P, Verde P, et al. Randomized controlled trial on the efficacy of new alcohol-free chlorhexidine mouthrinses after 8 weeks. Int J Dent Hyg. 2015;13(2):110-6.
Zimmer, S., Korte, P., Verde, P., Ohmann, C., Naumova, E., & Jordan, R. A. (2015). Randomized controlled trial on the efficacy of new alcohol-free chlorhexidine mouthrinses after 8 weeks. International Journal of Dental Hygiene, 13(2), pp. 110-6. doi:10.1111/idh.12111.
Zimmer S, et al. Randomized Controlled Trial On the Efficacy of New Alcohol-free Chlorhexidine Mouthrinses After 8 Weeks. Int J Dent Hyg. 2015;13(2):110-6. PubMed PMID: 25382448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized controlled trial on the efficacy of new alcohol-free chlorhexidine mouthrinses after 8 weeks. AU - Zimmer,S, AU - Korte,P, AU - Verde,P, AU - Ohmann,C, AU - Naumova,E, AU - Jordan,R A, Y1 - 2014/11/09/ PY - 2014/09/22/accepted PY - 2014/11/11/entrez PY - 2014/11/11/pubmed PY - 2016/7/13/medline KW - chlorhexidine KW - controlled clinical trial KW - mouthrinse KW - random allocation KW - single-blind-method SP - 110 EP - 6 JF - International journal of dental hygiene JO - Int J Dent Hyg VL - 13 IS - 2 N2 - OBJECTIVES: To evaluate the efficacy of two alcohol-free antimicrobial mouthrinses in reducing plaque and gingivitis compared to an alcohol-containing rinse and toothbrushing alone. METHODS: One hundred and sixty healthy volunteers were enrolled in the randomized controlled trial. Participants were randomly and equally assigned to four groups: (i) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-containing rinse, positive control); (ii) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-free experimental rinse); (iii) toothbrushing + rinsing (0.06% CHX + 0.03% CPC + 0.025% NaF, alcohol-free experimental rinse); (iv) toothbrushing alone (negative control). At baseline, Quigley-Hein plaque index (QHI), modified proximal plaque index (MPPI), and papillary bleeding index (PBI) were recorded. All subjects brushed their teeth as usual during the study. Additionally, groups 1-3 rinsed twice daily. Eight weeks after baseline, indices were recorded again. anova with Bonferroni adjustment served for statistical analysis. RESULTS: One hundred and fifty-five participants were included into final analysis (i: n = 39, 2: n = 39, 3: n = 37, 4: n = 40). Experimental rinses (ii, iii) reduced QHI and MPPI to a higher extent than the negative control (iv), whereas no significant difference to the positive control was found. QHI: (i) 36.6%, (ii) 32.3%, (iii) 36.8%, (iv) 21.6%; MPPI: (i) 11.9%, (ii) 12.2%, (iii) 13.6%, (iv) 3.5%. For PBI, no statistically significant difference was found between groups: (i) 80.2%, (ii) 77.8%, (iii) 76.5% and (iv) 78.8%. CONCLUSIONS: With respect to QHI and MPPI, toothbrushing in combination with any rinse was more effective than toothbrushing alone. No statistically significant differences were found between the alcohol-free and the alcohol-containing control rinses. SN - 1601-5037 UR - https://www.unboundmedicine.com/medline/citation/25382448/Randomized_controlled_trial_on_the_efficacy_of_new_alcohol_free_chlorhexidine_mouthrinses_after_8_weeks_ L2 - https://doi.org/10.1111/idh.12111 DB - PRIME DP - Unbound Medicine ER -