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Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan.
Pancreas 2015; 44(1):53-8P

Abstract

OBJECTIVE

This study aimed to estimate the association of alcohol consumption and pancreatitis in Japan.

METHODS

We performed a nationwide case-control study, which included 982 patients (574 patients with acute pancreatitis and 408 patients with chronic pancreatitis) and 1015 controls who were individually matched for sex, age, hospital, and time of their first hospital visit. Conditional logistic regression was used to assess the association of alcohol consumption and smoking with pancreatitis.

RESULTS

The patients had a mean (SD) age of 57.6 (17.0) years; 71.8% were male. Compared with nondrinkers, alcohol consumption of less than 20 g/d was not associated with the risk for total pancreatitis (odds ratio [OR], 1.0; 95% confidence interval [CI], 0.7-1.4). In patients with acute pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40 ≤ ∼ < 60 g/d, 60 ≤ ∼ < 80 g/d, 80 ≤ ∼ < 100 g/d, and 100 g/d or greater were 1.7 (0.9-3.0), 3.1 (1.6-5.9), 4.2 (2.1-8.2), 5.3 (2.4-12.0), and 6.4 (3.4-12.4), respectively. In patients with chronic pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40 ≤ ∼ < 60 g/d, 60 ≤ ∼ < 80 g/d, 80 ≤ ∼ < 100 g/d, and 100 g/d or greater were 2.6 (1.2-5.5), 3.2 (1.5-7.1), 9.2 (4.1-20.3), 13.0 (5.3-31.6), and 19.6 (8.2-46.8), respectively.

CONCLUSIONS

Our study precisely measured the quantitative effect of alcohol on the risk for developing pancreatitis.

Authors+Show Affiliations

From the Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25386904

Citation

Kume, Kiyoshi, et al. "Alcohol Consumption and the Risk for Developing Pancreatitis: a Case-Control Study in Japan." Pancreas, vol. 44, no. 1, 2015, pp. 53-8.
Kume K, Masamune A, Ariga H, et al. Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan. Pancreas. 2015;44(1):53-8.
Kume, K., Masamune, A., Ariga, H., & Shimosegawa, T. (2015). Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan. Pancreas, 44(1), pp. 53-8. doi:10.1097/MPA.0000000000000256.
Kume K, et al. Alcohol Consumption and the Risk for Developing Pancreatitis: a Case-Control Study in Japan. Pancreas. 2015;44(1):53-8. PubMed PMID: 25386904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan. AU - Kume,Kiyoshi, AU - Masamune,Atsushi, AU - Ariga,Hiroyuki, AU - Shimosegawa,Tooru, PY - 2014/11/12/entrez PY - 2014/11/12/pubmed PY - 2016/11/9/medline SP - 53 EP - 8 JF - Pancreas JO - Pancreas VL - 44 IS - 1 N2 - OBJECTIVE: This study aimed to estimate the association of alcohol consumption and pancreatitis in Japan. METHODS: We performed a nationwide case-control study, which included 982 patients (574 patients with acute pancreatitis and 408 patients with chronic pancreatitis) and 1015 controls who were individually matched for sex, age, hospital, and time of their first hospital visit. Conditional logistic regression was used to assess the association of alcohol consumption and smoking with pancreatitis. RESULTS: The patients had a mean (SD) age of 57.6 (17.0) years; 71.8% were male. Compared with nondrinkers, alcohol consumption of less than 20 g/d was not associated with the risk for total pancreatitis (odds ratio [OR], 1.0; 95% confidence interval [CI], 0.7-1.4). In patients with acute pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40 ≤ ∼ < 60 g/d, 60 ≤ ∼ < 80 g/d, 80 ≤ ∼ < 100 g/d, and 100 g/d or greater were 1.7 (0.9-3.0), 3.1 (1.6-5.9), 4.2 (2.1-8.2), 5.3 (2.4-12.0), and 6.4 (3.4-12.4), respectively. In patients with chronic pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40 ≤ ∼ < 60 g/d, 60 ≤ ∼ < 80 g/d, 80 ≤ ∼ < 100 g/d, and 100 g/d or greater were 2.6 (1.2-5.5), 3.2 (1.5-7.1), 9.2 (4.1-20.3), 13.0 (5.3-31.6), and 19.6 (8.2-46.8), respectively. CONCLUSIONS: Our study precisely measured the quantitative effect of alcohol on the risk for developing pancreatitis. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/25386904/Alcohol_Consumption_and_the_Risk_for_Developing_Pancreatitis:_A_Case_Control_Study_in_Japan_ L2 - http://Insights.ovid.com/pubmed?pmid=25386904 DB - PRIME DP - Unbound Medicine ER -