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Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study.
Clin Rheumatol. 2016 May; 35(5):1263-70.CR

Abstract

To evaluate the efficacy and safety of hyaluronic acid (HA) and glucosamine sulfate (GS) in alleviating symptoms and improving function of Kashin-Beck disease (KBD). A cluster-randomized, placebo-controlled trial was conducted in 150 patients with KBD. Participants were randomly allocated to receive intra-articular injection hyaluronic acid (IAHA) for 4 weeks, oral GS for 12 weeks, or oral placebo for 12 weeks. The primary outcome measures were 20 % and 50 % reductions in pain from baseline measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index. Secondary outcome measures included WOMAC index parameters of pain, stiffness, and physical function. The third outcome measure was mean change in Lequence score. HA and GS were effective in reducing WOMAC pain by 20 % (differences of 43.5 % and 25.4 %) and 50 % (differences of 43.4 % and 26.9 %). Both HA and GS significantly reduced WOMAC pain, WOMAC stiffness, and WOMAC normalized score compared with placebo group (all P < 0.05). IAHA was significantly more effective than oral GS in improving WOMAC normalized score (P = 0.034), pain (P = 0.002), stiffness (P = 0.018), and function (P = 0.044). The results indicate that HA and GS were more effective than placebo in treating KBD and HA was more effective than GS.

Authors+Show Affiliations

Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, People's Republic of China. Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi'an, 710061, People's Republic of China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, People's Republic of China. Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi'an, 710061, People's Republic of China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, People's Republic of China. Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi'an, 710061, People's Republic of China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, People's Republic of China. Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi'an, 710061, People's Republic of China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. guox@mail.xjtu.edu.cn. Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, People's Republic of China. guox@mail.xjtu.edu.cn. Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi'an, 710061, People's Republic of China. guox@mail.xjtu.edu.cn. School of Public Health, Health Science Centre, Xi'an Jiaotong University, No 76 Yanta West Road, Xi'an, Shaanxi, 710061, People's Republic of China. guox@mail.xjtu.edu.cn.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25388643

Citation

Xia, Chuan-Tao, et al. "Hyaluronic Acid and Glucosamine Sulfate for Adult Kashin-Beck Disease: a Cluster-randomized, Placebo-controlled Study." Clinical Rheumatology, vol. 35, no. 5, 2016, pp. 1263-70.
Xia CT, Yu FF, Ren FL, et al. Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study. Clin Rheumatol. 2016;35(5):1263-70.
Xia, C. T., Yu, F. F., Ren, F. L., Fang, H., & Guo, X. (2016). Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study. Clinical Rheumatology, 35(5), 1263-70. https://doi.org/10.1007/s10067-014-2809-6
Xia CT, et al. Hyaluronic Acid and Glucosamine Sulfate for Adult Kashin-Beck Disease: a Cluster-randomized, Placebo-controlled Study. Clin Rheumatol. 2016;35(5):1263-70. PubMed PMID: 25388643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study. AU - Xia,Chuan-Tao, AU - Yu,Fang-Fang, AU - Ren,Feng-Ling, AU - Fang,Hua, AU - Guo,Xiong, Y1 - 2014/11/12/ PY - 2014/06/22/received PY - 2014/10/17/accepted PY - 2014/08/12/revised PY - 2014/11/13/entrez PY - 2014/11/13/pubmed PY - 2017/2/10/medline KW - Glucosamine sulfate (GS) KW - Hyaluronic acid (HA) KW - Kashin-Beck disease KW - WOMAC index SP - 1263 EP - 70 JF - Clinical rheumatology JO - Clin. Rheumatol. VL - 35 IS - 5 N2 - To evaluate the efficacy and safety of hyaluronic acid (HA) and glucosamine sulfate (GS) in alleviating symptoms and improving function of Kashin-Beck disease (KBD). A cluster-randomized, placebo-controlled trial was conducted in 150 patients with KBD. Participants were randomly allocated to receive intra-articular injection hyaluronic acid (IAHA) for 4 weeks, oral GS for 12 weeks, or oral placebo for 12 weeks. The primary outcome measures were 20 % and 50 % reductions in pain from baseline measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index. Secondary outcome measures included WOMAC index parameters of pain, stiffness, and physical function. The third outcome measure was mean change in Lequence score. HA and GS were effective in reducing WOMAC pain by 20 % (differences of 43.5 % and 25.4 %) and 50 % (differences of 43.4 % and 26.9 %). Both HA and GS significantly reduced WOMAC pain, WOMAC stiffness, and WOMAC normalized score compared with placebo group (all P < 0.05). IAHA was significantly more effective than oral GS in improving WOMAC normalized score (P = 0.034), pain (P = 0.002), stiffness (P = 0.018), and function (P = 0.044). The results indicate that HA and GS were more effective than placebo in treating KBD and HA was more effective than GS. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/25388643/Hyaluronic_acid_and_glucosamine_sulfate_for_adult_Kashin_Beck_disease:_a_cluster_randomized_placebo_controlled_study_ L2 - https://dx.doi.org/10.1007/s10067-014-2809-6 DB - PRIME DP - Unbound Medicine ER -