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A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats.
J Physiol Sci. 2015 Jan; 65(1):121-30.JP

Abstract

The signaling molecule 5'-AMP-activated protein kinase plays a pivotal role in metabolic adaptations. Treatment with 5-aminoimidazole-4-carboxamide-1-β-D-ribofranoside (AICAR) promotes the expression of metabolic regulators and components involved in glucose uptake, mitochondrial biogenesis, and fatty acid oxidation in skeletal muscle cells. Our aim was to determine whether AICAR-induced changes in metabolic regulators and components were more prominent in white or red muscle. Rats were treated with AICAR (1 mg/g body weight/day) for 14 days, resulting in increased expression levels of nicotinamide phosphoribosyltransferase (NAMPT), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), glucose transporter 4 proteins, and enhanced mitochondrial biogenesis. These changes were more prominent in white rather than red gastrocnemius muscle or were only observed in the white gastrocnemius. Our results suggest that AICAR induces the expression of metabolic regulators and components, especially in type II (B) fibers.

Authors+Show Affiliations

Faculty of Life Design, Tohoku Institute of Technology, 6 Futatsusawa, Taihaku-ku, Sendai, Miyagi, 982-8588, Japan, suwa-m@tohtech.ac.jp.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25388945

Citation

Suwa, Masataka, et al. "A Comparison of Chronic AICAR Treatment-induced Metabolic Adaptations in Red and White Muscles of Rats." The Journal of Physiological Sciences : JPS, vol. 65, no. 1, 2015, pp. 121-30.
Suwa M, Nakano H, Radak Z, et al. A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats. J Physiol Sci. 2015;65(1):121-30.
Suwa, M., Nakano, H., Radak, Z., & Kumagai, S. (2015). A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats. The Journal of Physiological Sciences : JPS, 65(1), 121-30. https://doi.org/10.1007/s12576-014-0349-0
Suwa M, et al. A Comparison of Chronic AICAR Treatment-induced Metabolic Adaptations in Red and White Muscles of Rats. J Physiol Sci. 2015;65(1):121-30. PubMed PMID: 25388945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats. AU - Suwa,Masataka, AU - Nakano,Hiroshi, AU - Radak,Zsolt, AU - Kumagai,Shuzo, Y1 - 2014/11/12/ PY - 2014/03/26/received PY - 2014/10/30/accepted PY - 2014/11/13/entrez PY - 2014/11/13/pubmed PY - 2015/9/16/medline SP - 121 EP - 30 JF - The journal of physiological sciences : JPS JO - J Physiol Sci VL - 65 IS - 1 N2 - The signaling molecule 5'-AMP-activated protein kinase plays a pivotal role in metabolic adaptations. Treatment with 5-aminoimidazole-4-carboxamide-1-β-D-ribofranoside (AICAR) promotes the expression of metabolic regulators and components involved in glucose uptake, mitochondrial biogenesis, and fatty acid oxidation in skeletal muscle cells. Our aim was to determine whether AICAR-induced changes in metabolic regulators and components were more prominent in white or red muscle. Rats were treated with AICAR (1 mg/g body weight/day) for 14 days, resulting in increased expression levels of nicotinamide phosphoribosyltransferase (NAMPT), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), glucose transporter 4 proteins, and enhanced mitochondrial biogenesis. These changes were more prominent in white rather than red gastrocnemius muscle or were only observed in the white gastrocnemius. Our results suggest that AICAR induces the expression of metabolic regulators and components, especially in type II (B) fibers. SN - 1880-6562 UR - https://www.unboundmedicine.com/medline/citation/25388945/A_comparison_of_chronic_AICAR_treatment_induced_metabolic_adaptations_in_red_and_white_muscles_of_rats_ L2 - https://dx.doi.org/10.1007/s12576-014-0349-0 DB - PRIME DP - Unbound Medicine ER -