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Comparison of ondansetron and meperidine for treatment of postoperative shivering: a randomized controlled clinical trial.
Iran Red Crescent Med J. 2014 Aug; 16(8):e13079.IR

Abstract

BACKGROUND

The involved neurotransmitter pathways in the postoperative shivering (POS) are poorly understood. Recently, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to prevent POS. We investigated the effect of ondansetron, a 5-HT3 antagonist that is used to treat postoperative nausea and vomiting, on shivering.

OBJECTIVES

This study aimed to compare the efficacy of ondansetron and meperidine in the treatment of shivering after general anesthesia.

PATIENTS AND METHODS

In this double-blinded randomized clinical trial, 83 patients (age range, 18-60 years) who had shivering after general anesthesia were randomly allocated to any of these three groups: Group A, (number = 27) received 4 mg of intravenous ondansetron, Group B, (number = 27) received 8 mg of intravenous ondansetron, and Group C, (number = 29) received 0.4 mg/kg of intravenous meperidine at recovery room. The surface temperatures and the incidence as well as intensity of shivering were recorded.

RESULTS

Shivering was controlled in 16 patients (59%) in Group A, 22 (81%) in Group B, and 25 (86%) in Group C (P = 0.01). Within each group, there were no significant differences among the surface temperature in recovery room. Patients in groups A and B had significantly lower incidence of nausea and vomiting than group C (P = 0.01).

CONCLUSIONS

Ondansetron and meperidine have similar effects on shivering. We concluded that 8 mg of intravenous ondansetron can control shivering and this is the dose of choice, especially in patients with POS with nausea and vomiting.

Authors+Show Affiliations

Department of Anesthesiology, Imam Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, IR Iran.Department of Anesthesiology, Imam Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, IR Iran.Department of Anesthesiology, Imam Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, IR Iran.Department of Anesthesiology, Imam Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, IR Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25389473

Citation

Mahoori, Alireza, et al. "Comparison of Ondansetron and Meperidine for Treatment of Postoperative Shivering: a Randomized Controlled Clinical Trial." Iranian Red Crescent Medical Journal, vol. 16, no. 8, 2014, pp. e13079.
Mahoori A, Noroozinia H, Hasani E, et al. Comparison of ondansetron and meperidine for treatment of postoperative shivering: a randomized controlled clinical trial. Iran Red Crescent Med J. 2014;16(8):e13079.
Mahoori, A., Noroozinia, H., Hasani, E., & Soltanahmadi, M. (2014). Comparison of ondansetron and meperidine for treatment of postoperative shivering: a randomized controlled clinical trial. Iranian Red Crescent Medical Journal, 16(8), e13079. https://doi.org/10.5812/ircmj.13079
Mahoori A, et al. Comparison of Ondansetron and Meperidine for Treatment of Postoperative Shivering: a Randomized Controlled Clinical Trial. Iran Red Crescent Med J. 2014;16(8):e13079. PubMed PMID: 25389473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of ondansetron and meperidine for treatment of postoperative shivering: a randomized controlled clinical trial. AU - Mahoori,Alireza, AU - Noroozinia,Heydar, AU - Hasani,Ebrahim, AU - Soltanahmadi,Maryam, Y1 - 2014/08/05/ PY - 2013/06/19/received PY - 2013/09/28/revised PY - 2014/05/21/accepted PY - 2014/11/13/entrez PY - 2014/11/13/pubmed PY - 2014/11/13/medline KW - Adverse Effects KW - Anesthetics KW - Meperidine KW - Ondansetron KW - Shivering KW - Therapeutics SP - e13079 EP - e13079 JF - Iranian Red Crescent medical journal JO - Iran Red Crescent Med J VL - 16 IS - 8 N2 - BACKGROUND: The involved neurotransmitter pathways in the postoperative shivering (POS) are poorly understood. Recently, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to prevent POS. We investigated the effect of ondansetron, a 5-HT3 antagonist that is used to treat postoperative nausea and vomiting, on shivering. OBJECTIVES: This study aimed to compare the efficacy of ondansetron and meperidine in the treatment of shivering after general anesthesia. PATIENTS AND METHODS: In this double-blinded randomized clinical trial, 83 patients (age range, 18-60 years) who had shivering after general anesthesia were randomly allocated to any of these three groups: Group A, (number = 27) received 4 mg of intravenous ondansetron, Group B, (number = 27) received 8 mg of intravenous ondansetron, and Group C, (number = 29) received 0.4 mg/kg of intravenous meperidine at recovery room. The surface temperatures and the incidence as well as intensity of shivering were recorded. RESULTS: Shivering was controlled in 16 patients (59%) in Group A, 22 (81%) in Group B, and 25 (86%) in Group C (P = 0.01). Within each group, there were no significant differences among the surface temperature in recovery room. Patients in groups A and B had significantly lower incidence of nausea and vomiting than group C (P = 0.01). CONCLUSIONS: Ondansetron and meperidine have similar effects on shivering. We concluded that 8 mg of intravenous ondansetron can control shivering and this is the dose of choice, especially in patients with POS with nausea and vomiting. SN - 2074-1804 UR - https://www.unboundmedicine.com/medline/citation/25389473/Comparison_of_ondansetron_and_meperidine_for_treatment_of_postoperative_shivering:_a_randomized_controlled_clinical_trial_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25389473/ DB - PRIME DP - Unbound Medicine ER -
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