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The status of vitamin B12 and folate among Chinese women: a population-based cross-sectional study in northwest China.
PLoS One. 2014; 9(11):e112586.Plos

Abstract

OBJECTIVE

To assess the status of the vitamin B12 and folate of Chinese women living in northwest China.

METHODS

A population-based cross-sectional study was conducted in 2008 among Chinese women aged 10-49 years living in Shaanxi province of northwest China. A stratified multistage random sampling method was adopted to obtain a sample of 1170 women. The women were interviewed for collection of their background information and their plasma vitamin B12 and folate were measured with the immunoassay method. The status of both vitamins was evaluated and the prevalence of deficiency was estimated.

RESULTS

The median value of the women was 214.5 pg/mL for vitamin B12 and 4.6 ng/mL for folate. The urban women had a significantly higher vitamin B12 (254.1 vs. 195.9 pg/mL) but lower folate (4.4 vs. 4.7 ng/mL) than rural women. Total prevalence of deficiency was 45.5% (95% CI: 42.6% ∼ 48.4%) for vitamin B12 and 14.7% (95% CI: 12.6% ∼ 16.8%) for folate. About 36% of women presented vitamin B12 deficiency alone, 5.2% belonged to folate deficiency alone and 9.5% was combined deficiency in both vitamins. More than 25% of the women were in marginal vitamin B12 status (200-299 pg/mL) and 60% in marginal status of folate (3-6 ng/mL). About 75.2% of rural women with folate deficiency were deficient in vitamin B12 and 46% for urban women. Quantile regression model found decreasing coefficient of folate status across 73 different quantiles of vitamin B12, which indicated that the women with folate deficiency had lower vitamin B12 significantly compared with those with no deficiency.

CONCLUSIONS

The deficiency of vitamin B12 and folate is still prevalent among the Chinese women in northwest China. Vitamin B12 deficiency could be more serious and the improvement of poor vitamin B12 status should be invoked when practicing the supplementation of folate against the neural tube defects in northwest China.

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25390898

Citation

Dang, Shaonong, et al. "The Status of Vitamin B12 and Folate Among Chinese Women: a Population-based Cross-sectional Study in Northwest China." PloS One, vol. 9, no. 11, 2014, pp. e112586.
Dang S, Yan H, Zeng L, et al. The status of vitamin B12 and folate among Chinese women: a population-based cross-sectional study in northwest China. PLoS One. 2014;9(11):e112586.
Dang, S., Yan, H., Zeng, L., Wang, Q., Li, Q., Xiao, S., & Fan, X. (2014). The status of vitamin B12 and folate among Chinese women: a population-based cross-sectional study in northwest China. PloS One, 9(11), e112586. https://doi.org/10.1371/journal.pone.0112586
Dang S, et al. The Status of Vitamin B12 and Folate Among Chinese Women: a Population-based Cross-sectional Study in Northwest China. PLoS One. 2014;9(11):e112586. PubMed PMID: 25390898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The status of vitamin B12 and folate among Chinese women: a population-based cross-sectional study in northwest China. AU - Dang,Shaonong, AU - Yan,Hong, AU - Zeng,Lingxia, AU - Wang,Quanli, AU - Li,Qiang, AU - Xiao,Shengbin, AU - Fan,Xiaojing, Y1 - 2014/11/12/ PY - 2014/08/24/received PY - 2014/10/08/accepted PY - 2014/11/13/entrez PY - 2014/11/13/pubmed PY - 2015/7/7/medline SP - e112586 EP - e112586 JF - PloS one JO - PLoS One VL - 9 IS - 11 N2 - OBJECTIVE: To assess the status of the vitamin B12 and folate of Chinese women living in northwest China. METHODS: A population-based cross-sectional study was conducted in 2008 among Chinese women aged 10-49 years living in Shaanxi province of northwest China. A stratified multistage random sampling method was adopted to obtain a sample of 1170 women. The women were interviewed for collection of their background information and their plasma vitamin B12 and folate were measured with the immunoassay method. The status of both vitamins was evaluated and the prevalence of deficiency was estimated. RESULTS: The median value of the women was 214.5 pg/mL for vitamin B12 and 4.6 ng/mL for folate. The urban women had a significantly higher vitamin B12 (254.1 vs. 195.9 pg/mL) but lower folate (4.4 vs. 4.7 ng/mL) than rural women. Total prevalence of deficiency was 45.5% (95% CI: 42.6% ∼ 48.4%) for vitamin B12 and 14.7% (95% CI: 12.6% ∼ 16.8%) for folate. About 36% of women presented vitamin B12 deficiency alone, 5.2% belonged to folate deficiency alone and 9.5% was combined deficiency in both vitamins. More than 25% of the women were in marginal vitamin B12 status (200-299 pg/mL) and 60% in marginal status of folate (3-6 ng/mL). About 75.2% of rural women with folate deficiency were deficient in vitamin B12 and 46% for urban women. Quantile regression model found decreasing coefficient of folate status across 73 different quantiles of vitamin B12, which indicated that the women with folate deficiency had lower vitamin B12 significantly compared with those with no deficiency. CONCLUSIONS: The deficiency of vitamin B12 and folate is still prevalent among the Chinese women in northwest China. Vitamin B12 deficiency could be more serious and the improvement of poor vitamin B12 status should be invoked when practicing the supplementation of folate against the neural tube defects in northwest China. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25390898/The_status_of_vitamin_B12_and_folate_among_Chinese_women:_a_population_based_cross_sectional_study_in_northwest_China_ L2 - https://dx.plos.org/10.1371/journal.pone.0112586 DB - PRIME DP - Unbound Medicine ER -