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Effects of phencyclidine-like drugs on punished behavior in rats.
J Pharmacol Exp Ther. 1989 Mar; 248(3):997-1002.JP

Abstract

The effects of phencyclidine (PCP) and a number of PCP-like drugs on punished responding in rats were compared to those of chlordiazepoxide and morphine. Twenty rats, trained to lever-press for food reinforcement, were tested under a modified Geller-Seifter procedure using a multiple schedule with responding in one component reinforced under a fixed-interval 60-sec schedule while each response in the other component resulted in both food and brief electric shock presentation. Chlordiazepoxide, PCP, etoxadrol, (+)-N-allylnormetazocine and (-)-beta-cyclazocine all resulted in selective increases in rates of responding during the punishment component. Two drugs with predominant opiate-agonist actions in vivo, (-)-alpha-cyclazocine and morphine, did not increase punished responding at any dose tested. These results confirm previous research using pigeons that had shown antipunishment effects of PCP and provide further evidence for an overlap in the pharmacology of PCP-like drugs and depressant drugs such as barbiturates and benzodiazepines. The concordance between the discriminative stimulus properties and antipunishment effects of PCP-like drugs and actions at the PCP receptor suggests that the PCP receptor may play a role in both behavioral actions of this group of drugs.

Authors+Show Affiliations

Department of Psychology, Virginia Commonwealth University, Richmond.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2539469

Citation

Porter, J H., et al. "Effects of Phencyclidine-like Drugs On Punished Behavior in Rats." The Journal of Pharmacology and Experimental Therapeutics, vol. 248, no. 3, 1989, pp. 997-1002.
Porter JH, Wiley JL, Balster RL. Effects of phencyclidine-like drugs on punished behavior in rats. J Pharmacol Exp Ther. 1989;248(3):997-1002.
Porter, J. H., Wiley, J. L., & Balster, R. L. (1989). Effects of phencyclidine-like drugs on punished behavior in rats. The Journal of Pharmacology and Experimental Therapeutics, 248(3), 997-1002.
Porter JH, Wiley JL, Balster RL. Effects of Phencyclidine-like Drugs On Punished Behavior in Rats. J Pharmacol Exp Ther. 1989;248(3):997-1002. PubMed PMID: 2539469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of phencyclidine-like drugs on punished behavior in rats. AU - Porter,J H, AU - Wiley,J L, AU - Balster,R L, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 997 EP - 1002 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 248 IS - 3 N2 - The effects of phencyclidine (PCP) and a number of PCP-like drugs on punished responding in rats were compared to those of chlordiazepoxide and morphine. Twenty rats, trained to lever-press for food reinforcement, were tested under a modified Geller-Seifter procedure using a multiple schedule with responding in one component reinforced under a fixed-interval 60-sec schedule while each response in the other component resulted in both food and brief electric shock presentation. Chlordiazepoxide, PCP, etoxadrol, (+)-N-allylnormetazocine and (-)-beta-cyclazocine all resulted in selective increases in rates of responding during the punishment component. Two drugs with predominant opiate-agonist actions in vivo, (-)-alpha-cyclazocine and morphine, did not increase punished responding at any dose tested. These results confirm previous research using pigeons that had shown antipunishment effects of PCP and provide further evidence for an overlap in the pharmacology of PCP-like drugs and depressant drugs such as barbiturates and benzodiazepines. The concordance between the discriminative stimulus properties and antipunishment effects of PCP-like drugs and actions at the PCP receptor suggests that the PCP receptor may play a role in both behavioral actions of this group of drugs. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/2539469/Effects_of_phencyclidine_like_drugs_on_punished_behavior_in_rats_ L2 - http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2539469 DB - PRIME DP - Unbound Medicine ER -