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Molecularly imprinted polymers based on SBA-15 for selective solid-phase extraction of baicalein from plasma samples.
Anal Bioanal Chem. 2015 Jan; 407(2):509-19.AB

Abstract

Highly selective molecularly imprinted mesoporous silica polymer (SBA-15@MIP) for baicalein (BAI) extraction was synthesized using a surface molecular imprinting technique on the SBA-15 supporter. Computational simulation was used to predict the optimal functional monomer for the rational design of SBA-15@MIP. Meanwhile, high adsorption capacity was obtained when a suitable yield of molecularly imprinted polymers (MIPs) layer was grafted onto the surface of SBA-15. Characterization and performance tests of the obtained polymer revealed that SBA-15@MIP possessed a highly ordered mesoporous structure, reached saturated adsorption within 60 min, and exhibited higher sorption capacity to the target molecule BAI compared with non-imprinted mesoporous silica polymer (SBA-15@NIP) and SBA-15. Finally, SBA-15@MIP was successfully applied to solid-phase extraction (SPE) coupled with high-performance liquid chromatography and ultraviolet detection (HPLC-UV) for the determination of trace BAI in plasma samples. Mean recoveries of BAI through the molecularly imprinted solid-phase extraction (MISPE) sorbent, non-imprinted solid-phase extraction (NISPE) sorbent, and SBA-15 solid-phase extraction (SBA-15-SPE) sorbent were 94.4, 22.7, and 10.7 %, respectively, and the relative standard deviations were 2.9, 2.6, and 3.6 %, respectively. These results reveal that SBA-15@MIP as a SPE sorbent has good applicability to selectively separate and enrich trace BAI from complex samples.

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Publisher Full Text (DOI)

Authors+Show Affiliations

He H
School of Pharmacy, Nanjing Medical University, Nanjing, 210029, China.
Gu X
No affiliation info available
Shi L
No affiliation info available
Hong J
No affiliation info available
Zhang H
No affiliation info available
Gao Y
No affiliation info available
Du S
No affiliation info available
Chen L
No affiliation info available

MeSH

AdsorptionAnimalsChromatography, High Pressure LiquidFlavanonesHumansMicroscopy, Electron, ScanningMolecular ImprintingPolymersRatsReproducibility of ResultsSilicon DioxideSolid Phase ExtractionSpectroscopy, Fourier Transform InfraredThermogravimetryUltraviolet Rays

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25395202

Citation

He, Hongliang, et al. "Molecularly Imprinted Polymers Based On SBA-15 for Selective Solid-phase Extraction of Baicalein From Plasma Samples." Analytical and Bioanalytical Chemistry, vol. 407, no. 2, 2015, pp. 509-19.
He H, Gu X, Shi L, et al. Molecularly imprinted polymers based on SBA-15 for selective solid-phase extraction of baicalein from plasma samples. Anal Bioanal Chem. 2015;407(2):509-19.
He, H., Gu, X., Shi, L., Hong, J., Zhang, H., Gao, Y., Du, S., & Chen, L. (2015). Molecularly imprinted polymers based on SBA-15 for selective solid-phase extraction of baicalein from plasma samples. Analytical and Bioanalytical Chemistry, 407(2), 509-19. https://doi.org/10.1007/s00216-014-8285-7
He H, et al. Molecularly Imprinted Polymers Based On SBA-15 for Selective Solid-phase Extraction of Baicalein From Plasma Samples. Anal Bioanal Chem. 2015;407(2):509-19. PubMed PMID: 25395202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecularly imprinted polymers based on SBA-15 for selective solid-phase extraction of baicalein from plasma samples. AU - He,Hongliang, AU - Gu,Xiaoli, AU - Shi,Liying, AU - Hong,Junli, AU - Zhang,Hongjuan, AU - Gao,Yankun, AU - Du,Shuhu, AU - Chen,Lina, Y1 - 2014/11/14/ PY - 2014/07/15/received PY - 2014/10/20/accepted PY - 2014/09/27/revised PY - 2014/11/15/entrez PY - 2014/11/15/pubmed PY - 2015/9/29/medline SP - 509 EP - 19 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 407 IS - 2 N2 - Highly selective molecularly imprinted mesoporous silica polymer (SBA-15@MIP) for baicalein (BAI) extraction was synthesized using a surface molecular imprinting technique on the SBA-15 supporter. Computational simulation was used to predict the optimal functional monomer for the rational design of SBA-15@MIP. Meanwhile, high adsorption capacity was obtained when a suitable yield of molecularly imprinted polymers (MIPs) layer was grafted onto the surface of SBA-15. Characterization and performance tests of the obtained polymer revealed that SBA-15@MIP possessed a highly ordered mesoporous structure, reached saturated adsorption within 60 min, and exhibited higher sorption capacity to the target molecule BAI compared with non-imprinted mesoporous silica polymer (SBA-15@NIP) and SBA-15. Finally, SBA-15@MIP was successfully applied to solid-phase extraction (SPE) coupled with high-performance liquid chromatography and ultraviolet detection (HPLC-UV) for the determination of trace BAI in plasma samples. Mean recoveries of BAI through the molecularly imprinted solid-phase extraction (MISPE) sorbent, non-imprinted solid-phase extraction (NISPE) sorbent, and SBA-15 solid-phase extraction (SBA-15-SPE) sorbent were 94.4, 22.7, and 10.7 %, respectively, and the relative standard deviations were 2.9, 2.6, and 3.6 %, respectively. These results reveal that SBA-15@MIP as a SPE sorbent has good applicability to selectively separate and enrich trace BAI from complex samples. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/25395202/Molecularly_imprinted_polymers_based_on_SBA_15_for_selective_solid_phase_extraction_of_baicalein_from_plasma_samples_ DB - PRIME DP - Unbound Medicine ER -