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Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection.
Ann Surg Oncol. 2015 May; 22(5):1513-9.AS

Abstract

BACKGROUND

The lymph node ratio (LNR) was proposed as a prognostic indicator in Stage III colorectal cancer (CRC) patients in recent studies. The purpose of this study was to evaluate the prognostic impact of the LNR in Stage IV CRC patients who have undergone curative resection.

METHODS

A retrospective review of 119 Stage IV CRC patients who underwent curative resection in our institute from 1997 to 2009 was performed. Patients were divided into two groups (low LNR and high LNR) by means of their median LNR. A disease-free survival (DFS) and an overall survival (OS) were analyzed using the Kaplan-Meier curve; multivariate analysis was performed using the Cox proportional hazard model.

RESULTS

The cutoff value for the LNR was 0.111. For the entire study group, the 5-year DFS was 22 % and the 5-year OS was 65 %. DFS was not significantly different between patients in the low LNR group and the high LNR group (25 and 19 %, respectively; P = 0.317), but OS was significantly higher in the low LNR group patients compared with the high LNR group patients (77 and 54 %, respectively; P < 0.001). Using multivariate analysis, we identified the LNR as an independent prognostic factor for OS, with a hazard ratio of 3.08 (95 % CI 1.38-8.19; P = 0.005).

CONCLUSIONS

LNR is a potent prognostic indicator for stratification in Stage IV CRC patients who have undergone curative resection.

Authors+Show Affiliations

Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan, tsu443@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25398278

Citation

Ozawa, Tsuyoshi, et al. "Prognostic Significance of the Lymph Node Ratio in Stage IV Colorectal Cancer Patients Who Have Undergone Curative Resection." Annals of Surgical Oncology, vol. 22, no. 5, 2015, pp. 1513-9.
Ozawa T, Ishihara S, Nishikawa T, et al. Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection. Ann Surg Oncol. 2015;22(5):1513-9.
Ozawa, T., Ishihara, S., Nishikawa, T., Tanaka, T., Tanaka, J., Kiyomatsu, T., Hata, K., Kawai, K., Nozawa, H., Kanazawa, T., Kazama, S., Yamaguchi, H., Sunami, E., Kitayama, J., & Watanabe, T. (2015). Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection. Annals of Surgical Oncology, 22(5), 1513-9. https://doi.org/10.1245/s10434-014-4184-6
Ozawa T, et al. Prognostic Significance of the Lymph Node Ratio in Stage IV Colorectal Cancer Patients Who Have Undergone Curative Resection. Ann Surg Oncol. 2015;22(5):1513-9. PubMed PMID: 25398278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection. AU - Ozawa,Tsuyoshi, AU - Ishihara,Soichiro, AU - Nishikawa,Takeshi, AU - Tanaka,Toshiaki, AU - Tanaka,Junichiro, AU - Kiyomatsu,Tomomichi, AU - Hata,Keisuke, AU - Kawai,Kazushige, AU - Nozawa,Hiroaki, AU - Kanazawa,Takamitsu, AU - Kazama,Shinsuke, AU - Yamaguchi,Hironori, AU - Sunami,Eiji, AU - Kitayama,Joji, AU - Watanabe,Toshiaki, Y1 - 2014/11/15/ PY - 2014/06/26/received PY - 2014/11/16/entrez PY - 2014/11/16/pubmed PY - 2016/1/13/medline SP - 1513 EP - 9 JF - Annals of surgical oncology JO - Ann. Surg. Oncol. VL - 22 IS - 5 N2 - BACKGROUND: The lymph node ratio (LNR) was proposed as a prognostic indicator in Stage III colorectal cancer (CRC) patients in recent studies. The purpose of this study was to evaluate the prognostic impact of the LNR in Stage IV CRC patients who have undergone curative resection. METHODS: A retrospective review of 119 Stage IV CRC patients who underwent curative resection in our institute from 1997 to 2009 was performed. Patients were divided into two groups (low LNR and high LNR) by means of their median LNR. A disease-free survival (DFS) and an overall survival (OS) were analyzed using the Kaplan-Meier curve; multivariate analysis was performed using the Cox proportional hazard model. RESULTS: The cutoff value for the LNR was 0.111. For the entire study group, the 5-year DFS was 22 % and the 5-year OS was 65 %. DFS was not significantly different between patients in the low LNR group and the high LNR group (25 and 19 %, respectively; P = 0.317), but OS was significantly higher in the low LNR group patients compared with the high LNR group patients (77 and 54 %, respectively; P < 0.001). Using multivariate analysis, we identified the LNR as an independent prognostic factor for OS, with a hazard ratio of 3.08 (95 % CI 1.38-8.19; P = 0.005). CONCLUSIONS: LNR is a potent prognostic indicator for stratification in Stage IV CRC patients who have undergone curative resection. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/25398278/Prognostic_significance_of_the_lymph_node_ratio_in_stage_IV_colorectal_cancer_patients_who_have_undergone_curative_resection_ L2 - https://dx.doi.org/10.1245/s10434-014-4184-6 DB - PRIME DP - Unbound Medicine ER -