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Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection.
Acta Otolaryngol 2014; 134(12):1265-74AO

Abstract

CONCLUSION

Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is considered to be a distinct entity in Japan. The combination of both HPV-DNA sequencing analysis and immunohistochemistry (IHC) for p16(INK4A) is useful to discriminate the OPSCC patients with a better prognosis from other cases, especially in the advanced stage. Surgical treatment is recommended for HPV-negative advanced cancer.

OBJECTIVE

The number of HPV-related OPSCCs has been increasing worldwide. However, the incidence and prognostic significance of this cancer in Japan have not yet been fully elucidated.

METHODS

Seventy-seven Japanese patients with OPSCC were enrolled in this study. The prevalence of HPV-DNA was assessed by PCR and sequencing. The expression of p16(INK4A) and p53 was examined by IHC. The clinicopathological parameters and disease-specific survival were analyzed for HPV-positive and -negative patients.

RESULTS

HPV-DNA was detected in 32 patients. Thirty-four patients were p16(INK4A)-positive by IHC. The patients who were positive for HPV infection were significantly younger. Furthermore, in the stage III or IV cases, the 3-year disease-specific survival of the HPV infection-positive group was significantly better than that of the HPV-negative group. Surgical treatment was demonstrated to lead to a good prognosis for the patients with HPV-negative advanced cancer.

Authors+Show Affiliations

Department of Head and Neck Surgery, Tokyo Medical and Dental University , Tokyo , Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25399886

Citation

Nomura, Fuminori, et al. "Clinical Characteristics of Japanese Oropharyngeal Squamous Cell Carcinoma Positive for Human Papillomavirus Infection." Acta Oto-laryngologica, vol. 134, no. 12, 2014, pp. 1265-74.
Nomura F, Sugimoto T, Kitagaki K, et al. Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection. Acta Otolaryngol. 2014;134(12):1265-74.
Nomura, F., Sugimoto, T., Kitagaki, K., Ito, T., Kawachi, H., Eishi, Y., ... Kishimoto, S. (2014). Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection. Acta Oto-laryngologica, 134(12), pp. 1265-74. doi:10.3109/00016489.2014.944272.
Nomura F, et al. Clinical Characteristics of Japanese Oropharyngeal Squamous Cell Carcinoma Positive for Human Papillomavirus Infection. Acta Otolaryngol. 2014;134(12):1265-74. PubMed PMID: 25399886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection. AU - Nomura,Fuminori, AU - Sugimoto,Taro, AU - Kitagaki,Keisuke, AU - Ito,Takashi, AU - Kawachi,Hiroshi, AU - Eishi,Yoshinobu, AU - Watanabe,Ken, AU - Igaue,Miki, AU - Shimizu,Norio, AU - Tomita,Makoto, AU - Kitamura,Ken, AU - Kishimoto,Seiji, PY - 2014/11/18/entrez PY - 2014/11/18/pubmed PY - 2015/8/19/medline KW - chemoradiotherapy KW - p16INK4A KW - p53 SP - 1265 EP - 74 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 134 IS - 12 N2 - CONCLUSION: Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is considered to be a distinct entity in Japan. The combination of both HPV-DNA sequencing analysis and immunohistochemistry (IHC) for p16(INK4A) is useful to discriminate the OPSCC patients with a better prognosis from other cases, especially in the advanced stage. Surgical treatment is recommended for HPV-negative advanced cancer. OBJECTIVE: The number of HPV-related OPSCCs has been increasing worldwide. However, the incidence and prognostic significance of this cancer in Japan have not yet been fully elucidated. METHODS: Seventy-seven Japanese patients with OPSCC were enrolled in this study. The prevalence of HPV-DNA was assessed by PCR and sequencing. The expression of p16(INK4A) and p53 was examined by IHC. The clinicopathological parameters and disease-specific survival were analyzed for HPV-positive and -negative patients. RESULTS: HPV-DNA was detected in 32 patients. Thirty-four patients were p16(INK4A)-positive by IHC. The patients who were positive for HPV infection were significantly younger. Furthermore, in the stage III or IV cases, the 3-year disease-specific survival of the HPV infection-positive group was significantly better than that of the HPV-negative group. Surgical treatment was demonstrated to lead to a good prognosis for the patients with HPV-negative advanced cancer. SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/25399886/Clinical_characteristics_of_Japanese_oropharyngeal_squamous_cell_carcinoma_positive_for_human_papillomavirus_infection_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016489.2014.944272 DB - PRIME DP - Unbound Medicine ER -