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Association between dietary inflammatory index and prostate cancer among Italian men.
Br J Nutr 2015; 113(2):278-83BJ

Abstract

Previous studies have shown that various dietary components may be implicated in the aetiology of prostate cancer, although the results remain equivocal. The possible relationship of inflammation derived from dietary exposures with prostate cancer risk has not been investigated. We examined the ability of a newly developed dietary inflammatory index (DII) to predict prostate cancer risk in a case-control study conducted in Italy between 1991 and 2002. A total of 1294 patients aged < 75 years with incident, histologically confirmed carcinoma of the prostate served as cases. A total of 1451 subjects aged < 75 years who were admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions served as controls. The DII was computed based on dietary intake assessed using a previously validated seventy-eight-item FFQ. Logistic regression models were used to estimate multivariable OR adjusted for age, study centre, years of education, social class, BMI, smoking status, family history of prostate cancer and total energy intake. Men with higher DII scores had a higher risk of prostate cancer when analysed using the DII as both continuous (OR 1.06, 95% CI 1.00, 1.13) and categorical, i.e., compared with men in the lowest quartile of the DII, men in the third and fourth quartiles were at elevated risk (OR(Quartile 3 v. 1) 1.32, 95% CI 1.03, 1.69 and OR(Quartile 4 v. 1) 1.33, 95% CI 1.01, 1.76; P trend= 0.04). These data suggest that a pro-inflammatory diet, as indicated by the increasing DII score, is a risk factor of prostate cancer in Italian men.

Authors+Show Affiliations

Cancer Prevention and Control Program, University of South Carolina,915 Greene Street, Suite 241,Columbia,SC29208,USA.Department of Epidemiology,IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri",Milan,Italy.S.O.C. Epidemiologia e Biostatistica, Centro di Riferimento Oncologico,Aviano (PN),Italy.Dipartimento di Epidemiologia,'Fondazione G. Pascale', Istituto Nazionale Tumori,Naples,Italy.S.O.C. Epidemiologia e Biostatistica, Centro di Riferimento Oncologico,Aviano (PN),Italy.Department of Clinical Sciences and Community Health,Università degli Studi di Milano,Milan,Italy.Cancer Prevention and Control Program, University of South Carolina,915 Greene Street, Suite 241,Columbia,SC29208,USA.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25400225

Citation

Shivappa, Nitin, et al. "Association Between Dietary Inflammatory Index and Prostate Cancer Among Italian Men." The British Journal of Nutrition, vol. 113, no. 2, 2015, pp. 278-83.
Shivappa N, Bosetti C, Zucchetto A, et al. Association between dietary inflammatory index and prostate cancer among Italian men. Br J Nutr. 2015;113(2):278-83.
Shivappa, N., Bosetti, C., Zucchetto, A., Montella, M., Serraino, D., La Vecchia, C., & Hébert, J. R. (2015). Association between dietary inflammatory index and prostate cancer among Italian men. The British Journal of Nutrition, 113(2), pp. 278-83. doi:10.1017/S0007114514003572.
Shivappa N, et al. Association Between Dietary Inflammatory Index and Prostate Cancer Among Italian Men. Br J Nutr. 2015 Jan 28;113(2):278-83. PubMed PMID: 25400225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between dietary inflammatory index and prostate cancer among Italian men. AU - Shivappa,Nitin, AU - Bosetti,Cristina, AU - Zucchetto,Antonella, AU - Montella,Maurizio, AU - Serraino,Diego, AU - La Vecchia,Carlo, AU - Hébert,James R, Y1 - 2014/11/17/ PY - 2014/11/18/entrez PY - 2014/11/18/pubmed PY - 2016/8/16/medline KW - Case–control studies KW - Diet KW - Dietary inflammatory index KW - Inflammation KW - Italy KW - Prostate cancer SP - 278 EP - 83 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 113 IS - 2 N2 - Previous studies have shown that various dietary components may be implicated in the aetiology of prostate cancer, although the results remain equivocal. The possible relationship of inflammation derived from dietary exposures with prostate cancer risk has not been investigated. We examined the ability of a newly developed dietary inflammatory index (DII) to predict prostate cancer risk in a case-control study conducted in Italy between 1991 and 2002. A total of 1294 patients aged < 75 years with incident, histologically confirmed carcinoma of the prostate served as cases. A total of 1451 subjects aged < 75 years who were admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions served as controls. The DII was computed based on dietary intake assessed using a previously validated seventy-eight-item FFQ. Logistic regression models were used to estimate multivariable OR adjusted for age, study centre, years of education, social class, BMI, smoking status, family history of prostate cancer and total energy intake. Men with higher DII scores had a higher risk of prostate cancer when analysed using the DII as both continuous (OR 1.06, 95% CI 1.00, 1.13) and categorical, i.e., compared with men in the lowest quartile of the DII, men in the third and fourth quartiles were at elevated risk (OR(Quartile 3 v. 1) 1.32, 95% CI 1.03, 1.69 and OR(Quartile 4 v. 1) 1.33, 95% CI 1.01, 1.76; P trend= 0.04). These data suggest that a pro-inflammatory diet, as indicated by the increasing DII score, is a risk factor of prostate cancer in Italian men. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25400225/Association_between_dietary_inflammatory_index_and_prostate_cancer_among_Italian_men_ L2 - https://www.cambridge.org/core/product/identifier/S0007114514003572/type/journal_article DB - PRIME DP - Unbound Medicine ER -